{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:48:13Z","timestamp":1789987693242,"version":"4.0.1"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jtim-2017-0003_s_016_w2aab3b8b8b1b7b1aab1c15b1Aa\">\n                  <jats:title>Background and Objective<\/jats:title>\n                  <jats:p>Liver cirrhosis is usually detected at the later stages of disease. This study is aimed to detect liver damage in patients with chronic liver disease using transitional elastography (TE) and to assess the biochemical parameters associated with liver damage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jtim-2017-0003_s_017_w2aab3b8b8b1b7b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In 578 patients, chronic liver disease based on etiology was diagnosed by clinical and laboratory tests. Liver damage was evaluated with TE (FibroScan\u00ae), while its association with biochemical parameters was performed using the logistic regression tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jtim-2017-0003_s_018_w2aab3b8b8b1b7b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, the main etiologies of liver damage were hepatitis C virus (HCV) (37%), alcoholic liver disease (ALD) (33%) and non-alcoholic steatohepatitis (NASH) (26%). Patients were 40 to 50 years of age. ALD and hepatitis B prevailed in men, whereas HCV and NASH in women. The stages of fibrosis were F0 (<jats:italic>n<\/jats:italic> = 121, 21%), F1 (<jats:italic>n<\/jats:italic> = 122, 21%), F2 (<jats:italic>n<\/jats:italic> = 58, 10%), F3 (<jats:italic>n<\/jats:italic> = 46, 8%) and F4 (<jats:italic>n<\/jats:italic> = 87, 15%). In patients with liver cirrhosis, ALD (<jats:italic>n<\/jats:italic> = 96\/217, 45%), HCV (<jats:italic>n<\/jats:italic> = 94\/217, 43%) and NASH (<jats:italic>n<\/jats:italic> = 21\/217, 10%) were the leading etiologies. Platelets count (OR=3.31, 95%CI 1.61-6.78), glucose (OR=3.07, 95%CI 1.50-6.26), gamma-glutamyl-transferase (OR=3.60, 95%CI 1.79-7.25), albumin (OR=3.89, 95%CI 1.61-9.36), and total bilirubin (OR=3.93, 95%CI 1.41-10.91) were associated to advanced stages of fibrosis (F3-F4) regardless of etiology. The concordance and positive predictive values of these parameters were higher as compared to other scores.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jtim-2017-0003_s_019_w2aab3b8b8b1b7b1aab1c15b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Asymptomatic liver disease due to HCV, ALD and NASH prevailed in young adults. Advanced liver damage assessed by TE was associated with five biochemical parameters. In conjunction, both methodologies may be useful for the early detection of fibrosis and cirrhosis in Latin America.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jtim-2017-0003","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T10:01:15Z","timestamp":1492077675000},"page":"49-57","source":"Crossref","is-referenced-by-count":21,"title":["Early detection of liver damage in Mexican patients with chronic liver disease"],"prefix":"10.1515","volume":"5","author":[{"given":"Rafael","family":"Torres-Valadez","sequence":"first","affiliation":[{"name":"Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Mexico and Health Sciences Center , University of Guadalajara , Guadalajara , Jalisco , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Mexico and Health Sciences Center , University of Guadalajara , Guadalajara , Jalisco , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Jose-Abrego","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Mexico and Health Sciences Center , University of Guadalajara , Guadalajara , Jalisco , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricruz","family":"Sepulveda-Villegas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Mexico and Health Sciences Center , University of Guadalajara , Guadalajara , Jalisco , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ojeda-Granados","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Mexico and Health Sciences Center , University of Guadalajara , Guadalajara , Jalisco , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Rivera-I\u00f1iguez","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Mexico and Health Sciences Center , University of Guadalajara , Guadalajara , Jalisco , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Panduro","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Mexico and Health Sciences Center , University of Guadalajara , Guadalajara , Jalisco , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"2023042508110266874_j_jtim-2017-0003_ref_001_w2aab3b8b8b1b7b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2197\u2013223.","DOI":"10.1016\/S0140-6736(12)61690-0"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_002_w2aab3b8b8b1b7b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Mokdad AA, Lopez AD, Shahraz S, Lozano R, Mokdad AH, Stanaway J, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med 2014; 12: 145.","DOI":"10.1186\/s12916-014-0145-y"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_003_w2aab3b8b8b1b7b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Panduro A, Roman S. Need of righteous attitudes towards eradication of hepatitis C virus infection in Latin America. World J Gastroenterol 2016; 22: 5137-42.","DOI":"10.3748\/wjg.v22.i22.5137"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_004_w2aab3b8b8b1b7b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Roman S, Zepeda-Carrillo EA, Moreno-Luna LE, Panduro A. Alcoholism and liver disease in Mexico: genetic and environmental factors. World J Gastroenterol 2013; 19: 7972-82.","DOI":"10.3748\/wjg.v19.i44.7972"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_005_w2aab3b8b8b1b7b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Roman S, Ojeda-Granados C, Ramos-Lopez O, Panduro A. Genome-based nutrition: an intervention strategy for the prevention and treatment of obesity and nonalcoholic steatohepatitis. World J Gastroenterol 2015; 21: 3449-61.","DOI":"10.3748\/wjg.v21.i12.3449"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_006_w2aab3b8b8b1b7b1ab2b2b6Aa","unstructured":"Consejo Nacional de Poblaci\u00f3n (CONAPO), Direcci\u00f3n General de Estad\u00edstica en Salud P\u00fablica (DGESP), Base de datos de las defunciones observadas en 2012, INEGI\/SS\u00bb y \u00abProyecciones de la poblaci\u00f3n de M\u00e9xico, 2010-2030\u00bb. Available at: http:\/\/www.conapo.gob.mx; http:\/\/pda.salud.gob.mx\/cubos\/. Accessed on March 4, 2017."},{"key":"2023042508110266874_j_jtim-2017-0003_ref_007_w2aab3b8b8b1b7b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Panduro A, Ramos-Lopez O, Campollo O, Zepeda-Carrillo EA, Gonzalez-Aldaco K, Torres-Valadez R et al. High frequency of the DRD2\/ ANKK1 A1 allele in Mexican Native Amerindians and Mestizos and its association with alcohol consumption. Drug Alcohol Depend 2017; 172: 66\u201372.","DOI":"10.1016\/j.drugalcdep.2016.12.006"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_008_w2aab3b8b8b1b7b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Roman S, Tanaka Y, Khan A, Kurbanov F, Kato H, Mizokami M, et al. Occult hepatitis B in the genotype H-infected Nahuas and Huichol native Mexican population. J Med Virol 2010; 82: 1527-36","DOI":"10.1002\/jmv.21846"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_009_w2aab3b8b8b1b7b1ab2b2b9Aa","doi-asserted-by":"crossref","unstructured":"Campollo O, Valencia-Salinas JJ, Berumen-Arellano A, P\u00e9rez-Aranda MA, Panduro-Cerda A, Segura-Ortega J. Epidemiological characteristics of liver cirrhosis at the Hospital Civil of Guadalajara. Salud Public Mex 1997; 39: 195-200.","DOI":"10.1590\/S0036-36341997000300004"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_010_w2aab3b8b8b1b7b1ab2b2c10Aa","doi-asserted-by":"crossref","unstructured":"Ramos-Lopez O, Martinez-Lopez E, Roman S, Fierro NA, Panduro A. Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico. World J Gastroenterol 2015; 21: 11552-66.","DOI":"10.3748\/wjg.v21.i41.11552"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_011_w2aab3b8b8b1b7b1ab2b2c11Aa","doi-asserted-by":"crossref","unstructured":"Regev A, Berho M, Jeffers LJ, Milikowski C, Molina EG, Pyrsopoulos NT, et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 2002; 97: 2614\u201318.","DOI":"10.1111\/j.1572-0241.2002.06038.x"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_012_w2aab3b8b8b1b7b1ab2b2c12Aa","doi-asserted-by":"crossref","unstructured":"Sandrin L, Fourquet B, Hasquenoph JM, Yon S, Fournier C, Mal F, et al., Transient elastography: a new non-invasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003; 29: 1705\u201313","DOI":"10.1016\/j.ultrasmedbio.2003.07.001"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_013_w2aab3b8b8b1b7b1ab2b2c13Aa","doi-asserted-by":"crossref","unstructured":"Foucher J, Chanteloup E, Vergniol J, Cast\u00e9ra L, Le Bail B, Adhoute X, et al. Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut 2006; 55: 403\u20138.","DOI":"10.1136\/gut.2005.069153"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_014_w2aab3b8b8b1b7b1ab2b2c14Aa","doi-asserted-by":"crossref","unstructured":"Wilder J, Patel K. The clinical utility of FibroScan\u00ae as a noninvasive diagnostic test for liver disease. Medical Devices: Evidence and Research. 2014; 7: 107\u201314.","DOI":"10.2147\/MDER.S46943"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_015_w2aab3b8b8b1b7b1ab2b2c15Aa","doi-asserted-by":"crossref","unstructured":"Castera L, Chan HL, Arrese M, Afdhal N, Bedossa P, Friedrich-Rust M et al. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol 2015; 63: 237-64.","DOI":"10.1016\/j.jhep.2015.04.006"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_016_w2aab3b8b8b1b7b1ab2b2c16Aa","doi-asserted-by":"crossref","unstructured":"Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012; 55:2005-23.","DOI":"10.1002\/hep.25762"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_017_w2aab3b8b8b1b7b1ab2b2c17Aa","doi-asserted-by":"crossref","unstructured":"Baranova A, Lal P, Birerdinc A, Younnossi ZM. Non-invasive markers for hepatic fibrosis. BMC Gastroenterol 2011; 11: 1-15.","DOI":"10.1186\/1471-230X-11-91"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_018_w2aab3b8b8b1b7b1ab2b2c18Aa","doi-asserted-by":"crossref","unstructured":"Gonzalez-Aldaco K, Rebello Pinho JR, Roman S, Gleyzer K, Fierro NA, Oyakama L et al. Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28\/IFNL4 Haplotypes in Populations from Mexico. Plos One 2016; 11:e0146258.","DOI":"10.1371\/journal.pone.0146258"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_019_w2aab3b8b8b1b7b1ab2b2c19Aa","doi-asserted-by":"crossref","unstructured":"Tremblay AJ, Morrissette H, Gagn\u00e9 JM, Bergeron J, Gagn\u00e9 C, Couture P. Validation of the Friedewald formula for the determination of lowdensity lipoprotein cholesterol compared with beta-quantification in a large population. Clin Biochem 2004; 37: 785-90.","DOI":"10.1016\/j.clinbiochem.2004.03.008"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_020_w2aab3b8b8b1b7b1ab2b2c20Aa","unstructured":"World Health Organization. Obesity and overweight. 2015. Available at: http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/en\/. Accessed on March 4, 2017."},{"key":"2023042508110266874_j_jtim-2017-0003_ref_021_w2aab3b8b8b1b7b1ab2b2c21Aa","doi-asserted-by":"crossref","unstructured":"M\u00e9ndez-S\u00e1nchez N, Aguilar-Ram\u00edrez JR, Reyes A, Dehesa M, Juarez A, Casta\u00f1eda B, et al. Etiology of liver cirrhosis in Mexico. Ann Hepatol 2004; 3: 30-3.","DOI":"10.1016\/S1665-2681(19)32122-2"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_022_w2aab3b8b8b1b7b1ab2b2c22Aa","doi-asserted-by":"crossref","unstructured":"Kershenobich D, Razavi HA, S\u00e1nchez-Avila JF, Bessone F, Coelho HS, Dagher L, et al. Trends and projections of hepatitis C virus epidemiology in Latin America. Liver Int 2011; 31: 18-29.","DOI":"10.1111\/j.1478-3231.2011.02538.x"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_023_w2aab3b8b8b1b7b1ab2b2c23Aa","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Espinosa LE, Trujillo-Trujillo ME, Mart\u00ednez-Mac\u00edas RF, Panduro A, Rivas-Estilla AM, Fierro NA, et al. Increase of drug use and genotype 3 in HCV-infected patients from Central West and Northeast Mexico. Ann Hepatol 2015; 14: 642-51.","DOI":"10.1016\/S1665-2681(19)30758-6"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_024_w2aab3b8b8b1b7b1ab2b2c24Aa","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Nazar\u00e1 ZH, Ruiz-Madrigal B, Mart\u00ednez-L\u00f3pez E, Roman S, Panduro A. Association of the e2 Allele of Apoe Gene to Hypertriglyceridemia and to Early-Onset Alcoholic Cirrhosis. Alcohol Clin Exp Res 2008; 32: 559-66.","DOI":"10.1111\/j.1530-0277.2007.00607.x"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_025_w2aab3b8b8b1b7b1ab2b2c25Aa","doi-asserted-by":"crossref","unstructured":"Robotin MC. Hepatitis B prevention and control: Lessons from the East and the West. World J Hepatol 2011; 3: 31\u201337.","DOI":"10.4254\/wjh.v3.i2.31"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_026_w2aab3b8b8b1b7b1ab2b2c26Aa","doi-asserted-by":"crossref","unstructured":"Fierro NA, Gonzalez-Aldaco K, Torres-Valadez R, Martinez-Lopez E, Roman S, Panduro A. Immunologic, metabolic and genetic factors in hepatitis C virus infection. World J Gastroenterol 2014; 20: 3443\u201356.","DOI":"10.3748\/wjg.v20.i13.3443"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_027_w2aab3b8b8b1b7b1ab2b2c27Aa","doi-asserted-by":"crossref","unstructured":"Roman S, Fierro NA, Moreno-Luna LE, Panduro A. Hepatitis B Virus Genotype H and Environmental Factors Associated to the Low Prevalence of Hepatocellular Carcinoma in Mexico. J Cancer Ther 2013; 4: 367-76.","DOI":"10.4236\/jct.2013.42A044"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_028_w2aab3b8b8b1b7b1ab2b2c28Aa","doi-asserted-by":"crossref","unstructured":"Ichino N, Osakabe K, Nishikawa T, Sugiyama H, Kato M, Kitahara S, et al. A new index for non-invasive assessment of liver fibrosis. World J Gastroenterol 2010; 16: 4809-16.","DOI":"10.3748\/wjg.v16.i38.4809"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_029_w2aab3b8b8b1b7b1ab2b2c29Aa","doi-asserted-by":"crossref","unstructured":"Haukeland JW, Konopski Z, Linnestad P, Azimy S, Marit L\u2298berg E, Haaland T, et al. Abnormal glucose tolerance is a predictor of steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease. Scand J Gastroenterol 2005; 40: 1469-77.","DOI":"10.1080\/00365520500264953"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_030_w2aab3b8b8b1b7b1ab2b2c30Aa","doi-asserted-by":"crossref","unstructured":"Niemel\u00e4 O. Biomarker-Based Approaches for Assessing Alcohol Use Disorders. Int J Environ Res Public Health 2016; 13: 166.","DOI":"10.3390\/ijerph13020166"},{"key":"2023042508110266874_j_jtim-2017-0003_ref_031_w2aab3b8b8b1b7b1ab2b2c31Aa","doi-asserted-by":"crossref","unstructured":"Roman S, Panduro A. Genomic medicine in gastroenterology: A new approach or a new specialty? World J Gastroenterol 2015; 21: 8227-37.","DOI":"10.3748\/wjg.v21.i27.8227"}],"container-title":["Journal of Translational Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/jtim\/5\/1\/article-p49.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jtim-2017-0003\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jtim-2017-0003\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T08:23:44Z","timestamp":1682411024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jtim-2017-0003\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,3,31]]},"published-print":{"date-parts":[[2017,3,31]]}},"alternative-id":["10.1515\/jtim-2017-0003"],"URL":"https:\/\/doi.org\/10.1515\/jtim-2017-0003","relation":{},"ISSN":["2224-4018"],"issn-type":[{"value":"2224-4018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}