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Evidence suggests that tumor cells undergoing RCD can modify the immunogenicity of the tumor microenvironment (TME), potentially enhancing its ability to suppress cancer progression and metastasis. In this review, we first explore the mechanisms of apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis, along with the crosstalk between these cell death modalities. We then discuss how these processes activate antigen-presenting cells, facilitate the cross-priming of CD8+ T cells, and trigger anti-tumor immune responses, highlighting the complex effects of novel forms of tumor cell death on TME and tumor biology. Furthermore, we summarize potential drugs and nanoparticles that can induce or inhibit these emerging RCD pathways and their therapeutic roles in cancer treatment. Finally, we put forward existing challenges and future prospects for targeting RCD in anti-cancer immunity. Overall, this review enhances our understanding of the molecular mechanisms and biological impacts of RCD-based therapies, providing new perspectives and strategies for cancer treatment.<\/jats:p>","DOI":"10.1515\/jtim-2025-0004","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:23:53Z","timestamp":1742376233000},"page":"10-32","source":"Crossref","is-referenced-by-count":103,"title":["Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity"],"prefix":"10.1515","volume":"13","author":[{"given":"Ziyu","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology , Changsha , Hunan Province , China"},{"name":"Furong Laboratory , Changsha , Hunan Province , China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology , Changsha , Hunan Province , China"},{"name":"Furong Laboratory , Changsha , Hunan Province , China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daishi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology , Changsha , Hunan Province , 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Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology , Changsha , Hunan Province , China"},{"name":"Furong Laboratory , Changsha , Hunan Province , China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-9727","authenticated-orcid":false,"given":"Guangtong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology , Changsha , Hunan Province , China"},{"name":"Furong Laboratory , Changsha , Hunan Province , China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-636X","authenticated-orcid":false,"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology , Changsha , Hunan Province , China"},{"name":"Furong Laboratory , Changsha , Hunan Province , China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University , Changsha , Hunan Province , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , 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