{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:36:38Z","timestamp":1792442198925,"version":"4.5.0"},"reference-count":186,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic enteropathies characterized by multiple superficial ulcers of the small intestine have long been under-recognized, particularly in their early stage. However, the occurrence of refractory occult bleeding and episodes of partial bowel obstruction in this disease severely impacts quality of life, while targeted therapeutic options remain limited. Although dysfunction of the prostaglandin metabolic pathway has been associated with mucosal damage, the underlying molecular mechanisms and potential therapeutic targets remain unclear. In recent years, in-depth investigations of nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy, along with the discovery of rare monogenic disorders affecting the prostaglandin metabolic pathway, have helped bridge this knowledge gap. A broader concept, termed \u201cprostaglandin-associated enteropathy (PGAE)\u201d, has since emerged, representing a monumental breakthrough in the differential diagnosis of nonspecific small intestinal ulcers. This narrative review focuses on prostaglandin metabolism and chronic intestinal ulcers, including NSAID-induced enteropathy and chronic enteropathies associated with solute carrier organic anion transporter family member 2A1 (\n                    <jats:italic>SLCO2A1<\/jats:italic>\n                    ) and phospholipase A2 group IVA (\n                    <jats:italic>PLA2G4A<\/jats:italic>\n                    ). By unraveling molecular connections and highlighting innovative therapeutic avenues, we aim to advance clinical management and improve the well-being and quality of life for patients with PGAE.\n                  <\/jats:p>","DOI":"10.1515\/jtim-2026-0020","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:03:29Z","timestamp":1774530209000},"page":"204-224","source":"Crossref","is-referenced-by-count":1,"title":["What we know about prostaglandin pathway dysfunction in chronic enteropathies: From endoscopy to molecular diagnosis"],"prefix":"10.1515","volume":"14","author":[{"given":"Shuaizhi","family":"Ruan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengguang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Tsinghua University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuowen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0285-2966","authenticated-orcid":false,"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9292-9225","authenticated-orcid":false,"given":"Jingnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"2026042612202565531_j_jtim-2026-0020_ref_001","doi-asserted-by":"crossref","unstructured":"Moreels TG, Singh A. 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Stomach Intest 1968;3:1539-1549 (In Japanese)."},{"key":"2026042612202565531_j_jtim-2026-0020_ref_113","doi-asserted-by":"crossref","unstructured":"Matsumoto T, Iida M, Matsui T, Yao T. Chronic nonspecific multiple ulcers of the small intestine: a proposal of the entity from Japanese gastroenterologists to Western enteroscopists. Gastrointest Endosc 2007;66:S99-S107.","DOI":"10.1016\/j.gie.2007.01.004"},{"key":"2026042612202565531_j_jtim-2026-0020_ref_114","doi-asserted-by":"crossref","unstructured":"Boydstun JS Jr, Gaffey TA, Bartholomew LG. Clinicopathologic study of nonspecific ulcers of the small intestine. Dig Dis Sci 1981;26:911-916.","DOI":"10.1007\/BF01309496"},{"key":"2026042612202565531_j_jtim-2026-0020_ref_115","doi-asserted-by":"crossref","unstructured":"Singh A. Cryptogenic multifocal ulcerating stenosing enteropathy (CMUSE) and\/ or chronic non-specific multiple ulcers of the small intestine (CNSU) and non-granulomatous ulcerating jejunoileitis (NGUJI). 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