{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:23:02Z","timestamp":1787750582239,"version":"build-2784847793"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jtim-2026-0031_s_008\">\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Patients with autoimmune diseases (ADs) are at an increased risk of developing hematological malignancies (HMs). While allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative option for HMs, the outcomes in patients with concomitant ADs and the effects of transplantation on autoimmune conditions remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jtim-2026-0031_s_009\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this real-world study, we compared transplantation outcomes between 41 patients with HMs and preexisting ADs and 123 matched controls with HMs but without ADs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jtim-2026-0031_s_010\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 65.8% of the patients with ADs had a disease duration of \u2265 3 years. All patients achieved hematological recovery. The AD group had a significantly higher incidence of chronic graft-versus-host disease (70.7%\n                      <jats:italic>vs<\/jats:italic>\n                      . 26.8%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). After a median follow-up of 24 (8\u201375) months, the 3-year overall survival (73.2% [95% CI: 60.2%\u201389.1%]\n                      <jats:italic>vs<\/jats:italic>\n                      . 76.3% [95% CI: 68.9%\u201384.4%],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.76) and disease-free survival rates (68.8% [95% CI: 55.6%\u201385.3%]\n                      <jats:italic>vs<\/jats:italic>\n                      . 74.7% [95% CI: 67.2%\u201382.9%],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.57) were comparable between the AD and control groups. No significant differences were observed in the 3-year cumulative incidence of relapse (7.7% [95% CI: 1.9%\u201318.8%]\n                      <jats:italic>vs<\/jats:italic>\n                      . 9.5% [95% CI: 5.0%\u201315.7%],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.61) or nonrelapse mortality (23.5% [95% CI: 11.5%\u201338.0%]\n                      <jats:italic>vs<\/jats:italic>\n                      . 16.7% [95% CI: 10.6%\u201323.9%],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.40). Multivariable analysis confirmed that preexisting AD was not an independent risk factor for survival, relapse, or nonrelapse mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jtim-2026-0031_s_011\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that allo-HSCT in patients with HMs and ADs is associated with survival outcomes that appear comparable to those in patients without ADs but also induces complete remission of AD in most patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jtim-2026-0031","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:18:16Z","timestamp":1781309896000},"page":"579-588","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of patients with hematological malignancies complicated with autoimmune diseases after allogeneic hematopoietic stem cell transplantation: A ten-year real-world study"],"prefix":"10.1515","volume":"14","author":[{"given":"Qiusha","family":"Huang","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Fu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyu","family":"An","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"He","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Mo","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhua","family":"Yan","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Han","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lv","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanping","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-6792","authenticated-orcid":false,"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China"},{"name":"National Clinical Research Center for Hematologic Disease , Beijing , China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing , China"},{"name":"Collaborative Innovation Center of Hematology, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"2026082612595944803_j_jtim-2026-0031_ref_001","doi-asserted-by":"crossref","unstructured":"Gutierrez-Arcelus M, Rich SS, Raychaudhuri S. Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. Nat Rev Genet 2016;17:160\u2013174.","DOI":"10.1038\/nrg.2015.33"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_002","doi-asserted-by":"crossref","unstructured":"Conrad N, Misra S, Verbakel JY, Verbeke G, Molenberghs G, Taylor PN, et al. Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK. Lancet 2023;401:1878\u2013 1890.","DOI":"10.1016\/S0140-6736(23)00457-9"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_003","doi-asserted-by":"crossref","unstructured":"Snowden JA, Badoglio M, Labopin M, Giebel S, McGrath E, Marjanovic Z, et al. Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases. Blood Adv 2017;1:2742\u20132755.","DOI":"10.1182\/bloodadvances.2017010041"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_004","doi-asserted-by":"crossref","unstructured":"Giat E, Ehrenfeld M, Shoenfeld Y. Cancer and autoimmune diseases. Autoimmun Rev 2017;16:1049\u20131057.","DOI":"10.1016\/j.autrev.2017.07.022"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_005","doi-asserted-by":"crossref","unstructured":"Wang HL, Zhou YM, Zhu GZ, Yang Z, Hua BJ. Malignancy as a comorbidity in rheumatic diseases: a retrospective hospital-based study. Clin Rheumatol 2018;37:81\u201385.","DOI":"10.1007\/s10067-017-3676-8"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_006","doi-asserted-by":"crossref","unstructured":"Hemminki K, Huang W, Sundquist J, Sundquist K, Ji J. Autoimmune diseases and hematological malignancies: Exploring the underlying mechanisms from epidemiological evidence. Semin Cancer Biol 2020;64:114\u2013121.","DOI":"10.1016\/j.semcancer.2019.06.005"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_007","doi-asserted-by":"crossref","unstructured":"Ramadan SM, Fouad TM, Summa V, Hasan SKh, Lo-Coco F. Acute myeloid leukemia developing in patients with autoimmune diseases. Haematologica 2012;97:805\u2013817.","DOI":"10.3324\/haematol.2011.056283"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_008","doi-asserted-by":"crossref","unstructured":"Van den Bergh M, Alvarez-Argote J, Panwala AH, Dasanu CA. Autoimmune disorders in patients with T-cell lymphoma: a comprehensive review. Curr Med Res Opin 2015;31:1861\u20131870.","DOI":"10.1185\/03007995.2015.1074066"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_009","doi-asserted-by":"crossref","unstructured":"Hough RE, Snowden JA, Wulffraat NM. Haemopoietic stem cell transplantation in autoimmune diseases: a European perspective. Br J Haematol 2005;128:432\u2013459.","DOI":"10.1111\/j.1365-2141.2004.05298.x"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_010","doi-asserted-by":"crossref","unstructured":"Farge D, Labopin M, Tyndall A, Fassas A, Mancardi GL, Van Laar J, et al. Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases. Haematologica 2010;95:284\u2013292.","DOI":"10.3324\/haematol.2009.013458"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_011","doi-asserted-by":"crossref","unstructured":"Kelsey PJ, Oliveira MC, Badoglio M, Sharrack B, Farge D, Snowden JA. Haematopoietic stem cell transplantation in autoimmune diseases: From basic science to clinical practice. Curr Res Transl Med 2016;64:71\u201382.","DOI":"10.1016\/j.retram.2016.03.003"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_012","doi-asserted-by":"crossref","unstructured":"Bell SM, Sharrack B, Snowden JA. Autologous hematopoietic cell transplantation in multiple sclerosis. Expert Opin Biol Ther 2017;17:77\u201386.","DOI":"10.1080\/14712598.2017.1239706"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_013","doi-asserted-by":"crossref","unstructured":"Burt RK, Balabanov R, Voltarelli J, Barreira A, Burman J. Autologous hematopoietic stem cell transplantation for multiple sclerosis--if confused or hesitant, remember: 'treat with standard immune suppressive drugs and if no inflammation, no response'. Mult Scler 2012;18:772\u2013775.","DOI":"10.1177\/1352458512442993"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_014","doi-asserted-by":"crossref","unstructured":"M F Silva J, Ladomenou F, Carpenter B, Chandra S, Sedlacek P, Formankova R, et al. Allogeneic hematopoietic stem cell transplantation for severe, refractory juvenile idiopathic arthritis. Blood Adv 2018;2:777\u2013786.","DOI":"10.1182\/bloodadvances.2017014449"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_015","doi-asserted-by":"crossref","unstructured":"Taylor J, Xiao W, Abdel-Wahab O. Diagnosis and classification of hematologic malignancies on the basis of genetics. Blood 2017;130:410\u2013423.","DOI":"10.1182\/blood-2017-02-734541"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_016","doi-asserted-by":"crossref","unstructured":"Greco R, Labopin M, Badoglio M, Veys P, Furtado Silva JM, Abinun M, et al. Allogeneic HSCT for Autoimmune Diseases: A Retrospective Study From the EBMT ADWP, IEWP, and PDWP Working Parties. Front Immunol 2019;10:1570.","DOI":"10.3389\/fimmu.2019.01570"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_017","doi-asserted-by":"crossref","unstructured":"Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant 2015;21:389\u2013401.","DOI":"10.1016\/j.bbmt.2014.12.001"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_018","unstructured":"Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J, et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant 1995;15:825\u2013828."},{"key":"2026082612595944803_j_jtim-2026-0031_ref_019","doi-asserted-by":"crossref","unstructured":"Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W, et al. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant 2006;38:291\u2013297.","DOI":"10.1038\/sj.bmt.1705445"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_020","doi-asserted-by":"crossref","unstructured":"Yan CH, Xu LP, Wang FR, Chen H, Han W, Wang Y, et al. Causes of mortality after haploidentical hematopoietic stem cell transplantation and the comparison with HLA-identical sibling hematopoietic stem cell transplantation. Bone Marrow Transplant 2016;51:391\u2013397.","DOI":"10.1038\/bmt.2015.306"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_021","doi-asserted-by":"crossref","unstructured":"Wang Y, Liu QF, Xu LP, Liu KY, Zhang XH, Ma X, et al. Haploidentical vs identical-sibling transplant for AML in remission: a multicenter, prospective study. Blood 2015;125:3956\u20133962.","DOI":"10.1182\/blood-2015-02-627786"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_022","doi-asserted-by":"crossref","unstructured":"Fan S, Hong H, Lu S, Wen Q, Hong S, Zhang X, et al. Artificial intelligence-based predictive model for relapse in acute myeloid leukemia patients following haploidentical hematopoietic cell transplantation. J Transl Int Med 2025;13:253\u2013266.","DOI":"10.1515\/jtim-2025-0028"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_023","doi-asserted-by":"crossref","unstructured":"Sun W, Sun Y, Mo X, Ma R, He Y, Zhang Y, et al. A novel and safe protocol for patients with severe comorbidity who undergo haploidentical hematopoietic stem cell transplantation: A single-center prospective study. J Transl Int Med 2025;13:128\u2013137.","DOI":"10.1515\/jtim-2025-0018"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_024","doi-asserted-by":"crossref","unstructured":"Lai YR, Chen YH, Hu DM, Jiang M, Liu QF, Liu L, et al. Multicenter phase II study of a combination of cyclosporine a, methotrexate and mycophenolate mofetil for GVHD prophylaxis: results of the Chinese Bone Marrow Transplant Cooperative Group (CBMTCG). J Hematol Oncol 2014;7:59.","DOI":"10.1186\/s13045-014-0059-3"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_025","doi-asserted-by":"crossref","unstructured":"Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W, et al. Treatment of acute leukemia with unmanipulated HLA-mismatched\/haploidentical blood and bone marrow transplantation. Biol Blood Marrow Transplant 2009;15:257\u2013265.","DOI":"10.1016\/j.bbmt.2008.11.025"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_026","doi-asserted-by":"crossref","unstructured":"Fan S, Yang Y, Lu S, Huang J, Zhao X, Cao Y, et al. DEK-NUP214 monitoring before and after allogeneic haematopoietic stem cell transplantation for acute myeloid leukemia: A report from the TROPHY study group. J Transl Int Med 2025;13:375\u2013385.","DOI":"10.1515\/jtim-2025-0032"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_027","doi-asserted-by":"crossref","unstructured":"Shlomchik MJ, Craft JE, Mamula MJ. From T to B and back again: positive feedback in systemic autoimmune disease. Nat Rev Immunol 2001;1:147\u2013153.","DOI":"10.1038\/35100573"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_028","doi-asserted-by":"crossref","unstructured":"Burt RK, Testori A, Craig R, Cohen B, Suffit R, Barr W. Hematopoietic stem cell transplantation for autoimmune diseases: what have we learned? J Autoimmun 2008;30:116\u2013120.","DOI":"10.1016\/j.jaut.2007.12.010"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_029","doi-asserted-by":"crossref","unstructured":"Tabbara IA, Zimmerman K, Morgan C, Nahleh Z. Allogeneic hematopoietic stem cell transplantation: complications and results. Arch Intern Med 2002;162:1558\u20131566.","DOI":"10.1001\/archinte.162.14.1558"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_030","doi-asserted-by":"crossref","unstructured":"Nash RA, McSweeney PA, Nelson JL, Wener M, Georges GE, Langston AA, et al. Allogeneic marrow transplantation in patients with severe systemic sclerosis: resolution of dermal fibrosis. Arthritis Rheum 2006;54:1982\u20131986.","DOI":"10.1002\/art.21908"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_031","doi-asserted-by":"crossref","unstructured":"Xu L, Chen H, Chen J, Han M, Huang H, Lai Y, et al. The consensus on indications, conditioning regimen, and donor selection of allogeneic hematopoietic cell transplantation for hematological diseases in China-recommendations from the Chinese Society of Hematology. J Hematol Oncol 2018;11:33.","DOI":"10.1186\/s13045-018-0564-x"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_032","doi-asserted-by":"crossref","unstructured":"Wang Y, Chen H, Chen J, Han M, Hu J, Jiong H, et al. The consensus on the monitoring, treatment, and prevention of leukemia relapse after allogeneic hematopoietic stem cell transplantation in China. Cancer Lett 2018;438:63\u201375.","DOI":"10.1016\/j.canlet.2018.08.030"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_033","doi-asserted-by":"crossref","unstructured":"Carpenter PA, Gooley TA, Boiko J, Lee CJ, Burroughs LM, Mehta R, et al. Decreasing chronic graft-versus-host disease rates in all populations. Blood Adv 2024;8:5829\u20135837.","DOI":"10.1182\/bloodadvances.2024012722"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_034","doi-asserted-by":"crossref","unstructured":"Zeiser R, Blazar BR. Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets. N Engl J Med 2017;377:2565\u20132579.","DOI":"10.1056\/NEJMra1703472"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_035","doi-asserted-by":"crossref","unstructured":"Dominguez-Villar M, Hafler DA. Regulatory T cells in autoimmune disease. Nat Immunol 2018;19:665\u2013673.","DOI":"10.1038\/s41590-018-0120-4"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_036","doi-asserted-by":"crossref","unstructured":"Li X, Gao Q, Feng Y, Zhang X. Developing role of B cells in the pathogenesis and treatment of chronic GVHD. Br J Haematol 2019;184:323\u2013336.","DOI":"10.1111\/bjh.15719"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_037","doi-asserted-by":"crossref","unstructured":"Lee DSW, Rojas OL, Gommerman JL. B cell depletion therapies in autoimmune disease: advances and mechanistic insights. Nat Rev Drug Discov 2021;20:179\u2013199.","DOI":"10.1038\/s41573-020-00092-2"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_038","doi-asserted-by":"crossref","unstructured":"McGeachy MJ, Cua DJ, Gaffen SL. The IL-17 Family of Cytokines in Health and Disease. Immunity 2019;50:892\u2013906.","DOI":"10.1016\/j.immuni.2019.03.021"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_039","doi-asserted-by":"crossref","unstructured":"Nonami A, Takenaka K, Sumida C, Aizawa K, Kamezaki K, Miyamoto T, et al. Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Beh\u00e7et's disease by up-front cord blood transplantation. Intern Med 2007;46:1753\u20131756.","DOI":"10.2169\/internalmedicine.46.0291"},{"key":"2026082612595944803_j_jtim-2026-0031_ref_040","doi-asserted-by":"crossref","unstructured":"Arita K, Murakami J, Wada A, Miyazono T, Sugiyama T. Changes in the autoantibody pattern during allogeneic stem-cell transplantation for acute myeloid leukemia complicated by systemic lupus erythematosus. Bone Marrow Transplant 2016;51:883\u2013884.","DOI":"10.1038\/bmt.2016.21"}],"container-title":["Journal of Translational Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jtim-2026-0031\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jtim-2026-0031\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:02:02Z","timestamp":1787749322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jtim-2026-0031\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,26]]},"published-print":{"date-parts":[[2026,8,26]]}},"alternative-id":["10.1515\/jtim-2026-0031"],"URL":"https:\/\/doi.org\/10.1515\/jtim-2026-0031","relation":{},"ISSN":["2224-4018"],"issn-type":[{"value":"2224-4018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]}}}