{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:46:18Z","timestamp":1784925978833,"version":"3.55.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Objectives: It has been well documented that the\nplatelet to lymphocyte ratio (PLR) and the neutrophil to\nlymphocyte ratio (NLR) are associated with outcomes for\npatients with gastric cancer, non-small cell lung cancer\nand acute heart failure. Inflammation may be the hidden\nfactor that explains the correlation between NLP, PLR, and\nthese diseases. However, to date, the data concerning NLR,\nPLR, and its association with inflammation are lacking\nin patients with rheumatoid arthritis (RA), thus, our aim\nto discuss whether NLR and PLR are associated with RA.\nMethods: Patients with RA and healthy individuals\nwere included according to the determined criteria,\nand laboratory indicators were measured.\nResults: PLR and NLR were significantly higher in RA\npatients compared with healthy controls (3.20\u00b12.06\nvs. 1.56\u00b10.47, P&lt;0.01; 192.85\u00b1101.78 vs. 103.49\u00b128.68,\nP&lt;0.01). When leukocytes, neutrophil percentage, neutrophil,\nlymphocyte, platelet, C-reactive protein (CRP),\nerythrocyte sedimentation rate (ESR), and rheumatoid\nfactor (RF) were considered as confounders (crude\nmodel), our results indicated that ESR and RF were correlated\nto RA. Of note, ESR, RF, and PLR were associated\nwith RA after further adjustment based on crude model\nfor PLR and NLR. Receiver operating characteristic (ROC)\ncurves analysis showed that PLR values higher than &gt;115.7 evaluated RA with a sensitivity of 82.5%, a specificity\nof 74.8% and area under the curve ( AUC ) of 0.847.\nConclusions:Our results suggest that PLR is associated\nwith RA, and PLR may be an underlying indicator indicating\nthe chronic subclinical inflammation in patients\nwith RA.<\/jats:p>","DOI":"10.1515\/med-2015-0037","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T12:53:16Z","timestamp":1430916796000},"source":"Crossref","is-referenced-by-count":24,"title":["Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in patients with rheumatoid arthritis"],"prefix":"10.1515","volume":"10","author":[{"given":"You-Fan","family":"Peng","sequence":"first","affiliation":[{"name":"Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Cao","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Hua","family":"Zeng","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital, Xin Jiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Diagnostic Centre, The First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Sen","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Xin Jiang Medical University, No.1-137, Liyushan Road, Xin\u2019shi Region, Urumqi.XinJiang, China 830011"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2015,4,14]]},"container-title":["Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/med\/open-issue\/article-10.1515-med-2015-0037\/article-10.1515-med-2015-0037.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2015-0037\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2015-0037\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T13:05:25Z","timestamp":1717592725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2015-0037\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,14]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,17]]},"published-print":{"date-parts":[[2015,1,1]]}},"alternative-id":["10.1515\/med-2015-0037"],"URL":"https:\/\/doi.org\/10.1515\/med-2015-0037","relation":{},"ISSN":["2391-5463"],"issn-type":[{"value":"2391-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,14]]}}}