{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:45:01Z","timestamp":1769089501394,"version":"3.49.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chemical pleurodesis is an effective treatment\nmodality to reduce recurrence of malignant effusion.\nSeveral agents have been used in chemical pleurodesis\nbut, it is not yet clear which is better. Eighteen Sprague-\nDawley rats were used and classified into three groups:\na group intrapleurally injected normal saline (group A,\nn=6), 400mg\/kg talc (group B, n=6), and 9mg\/kg mistletoe\nextraction (ME) (group C, n=6). Autopsy was performed to\nevaluate the pleural adhesion, pathologic examination of\npleura and lung and bronchoalveolar lavage fluid analysis\n4 weeks after pleurodesis. Both group B and C showed an\nobvious pleural adhesion and there was no significant difference\nin grade of pleural adhesion between two groups\n(p=0.58). The parietal pleural thickness in talc group than\nME group was significantly thicker (p=0.002) and the visceral\npleura of talc group showed marked foreign body\nreaction with fibrosis and many multinucleated giant\ncells associated with talc crystal. This study suggests that\npleurodesis using ME in condition without malignancy\nhas comparable effect to pleurodesis using talc. However,\nadditional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy\nof pleurodesis using ME.<\/jats:p>","DOI":"10.1515\/med-2015-0051","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T09:20:22Z","timestamp":1443086422000},"source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of mistletoe for chemical pleurodesis in\nrats without malignancy"],"prefix":"10.1515","volume":"10","author":[{"given":"Hyo Yeong","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Su","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoseok","family":"I","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahrong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pusan National University Hospital, Biomedical Research Institution, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,9,4]]},"container-title":["Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/med.2015.10.issue-1\/med-2015-0051\/med-2015-0051.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2015-0051\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2015-0051\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T13:05:19Z","timestamp":1717592719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2015-0051\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,4]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,5,28]]}},"alternative-id":["10.1515\/med-2015-0051"],"URL":"https:\/\/doi.org\/10.1515\/med-2015-0051","relation":{},"ISSN":["2391-5463"],"issn-type":[{"value":"2391-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,4]]}}}