{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:02:30Z","timestamp":1717632150511},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The goal of this study is to evaluate therapeutic\ntrends for several diseases that represent risk factors for\nstroke. The relative frequency of therapy with compounds\nthat influence the risk factors for stroke was monitored\nin a group of 3,290 patients who were hospitalised in the\nStroke Unit at the University Hospital in Hradec Kralove\nbetween 2005 and 2012. For most drugs monitored, the\nreasons for the significant decrease or increase in use were\ncauses other than the reduction of stroke risk. Despite this\nfinding, the majority of statistically significant changes\nhad, according to review of comparative studies, a posi-\ntive effect on prevention of stroke. Motivation to change\ntreatment of stroke risk factors, such as hypertension,\ndiabetes mellitus and hypercholesterolemia, was mainly\naimed at sufficient disease management with a minimum\nof adverse effects. On the other hand, optimization of\nstroke recurrence and economic factors were motivations\nto treatment changes in prevention with antiplatelets.\nAntidiabetics were associated with an increase in met-\nformin use and reduction in insulin use. For antihyperten-\nsives, the most significant reduction was associated with\nthe use of diuretics, although calcium channel blockers\nand beta-blockers are also less used. Additionally, the use\nof the ACE inhibitor ramipril increased<\/jats:p>","DOI":"10.1515\/med-2015-0060","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T17:54:27Z","timestamp":1490032467000},"source":"Crossref","is-referenced-by-count":0,"title":["Trends in the treatment of risk factors for stroke in a Czech stroke unit"],"prefix":"10.1515","volume":"10","author":[{"given":"Libor","family":"Simunek","sequence":"first","affiliation":[{"name":"University Hos- pital in Hradec Kr\u00e1lov\u00e9, Hradec Kralove, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Krajickova","sequence":"additional","affiliation":[{"name":"University Hos- pital in Hradec Kr\u00e1lov\u00e9, Hradec Kralove, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oldrich","family":"Vysata","sequence":"additional","affiliation":[{"name":"University Hos- pital in Hradec Kr\u00e1lov\u00e9, Hradec Kralove, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Valis","sequence":"additional","affiliation":[{"name":"University Hos- pital in Hradec Kr\u00e1lov\u00e9, Hradec Kralove, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,10,26]]},"container-title":["Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/med.2015.10.issue-1\/med-2015-0060\/med-2015-0060.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2015-0060\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2015-0060\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T13:05:39Z","timestamp":1717592739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2015-0060\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,26]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,17]]},"published-print":{"date-parts":[[2015,1,1]]}},"alternative-id":["10.1515\/med-2015-0060"],"URL":"https:\/\/doi.org\/10.1515\/med-2015-0060","relation":{},"ISSN":["2391-5463"],"issn-type":[{"value":"2391-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,26]]}}}