{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T19:10:06Z","timestamp":1718910606883},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The purpose of this study was to examine the efficacy rendered with a single dose of live attenuated measles, rubella, mumps, and varicella containing vaccine.<\/jats:p>\n               <jats:p>We inoculated healthcare workers (HCWs) with a single dose of vaccine to a disease lacking in antibody titer for those not meeting the criteria of our hospital (measles: &lt;16.0 (IgG enzyme immunoassay (EIA)), rubella: \u22641:32 (hemagglutination-inhibition), mumps: &lt;4.0 (IgG EIA), and varicella: &lt;4.0 (IgG EIA)). At 28\u201360 days after vaccination, the antibody titer was tested again.<\/jats:p>\n               <jats:p>We included 48 HCWs. A total of 32, 15, 31, and 10 individuals were inoculated with a single dose of measles-containing, rubella-containing, mumps, or varicella vaccine, respectively, and showed significant antibody elevation (9.2 \u00b1 12.3 to 27.6 \u00b1 215.6, p&lt;0.001; 8 \u00b1 1.2 to 32 \u00b1 65.5, p&lt;0.001; 3.0 \u00b1 1.0 to 13.1 \u00b1 8.6, p&lt;0.05; and 2.6 \u00b1 1.3 to 11.8 \u00b1 8.1, p&lt;0.001, respectively). Major side effects were not observed.<\/jats:p>\n               <jats:p>In a limited population, a single dose of live attenuated vaccine showed elevation of antibody titer without any severe adverse reactions. However, whether the post-vaccination response rate criteria of our university was fulfilled could not be determined owing to limited sample size.<\/jats:p>","DOI":"10.1515\/med-2016-0085","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T10:01:13Z","timestamp":1481277673000},"page":"482-488","source":"Crossref","is-referenced-by-count":2,"title":["Antibody Response to Live Attenuated Vaccines in Adults in Japan"],"prefix":"10.1515","volume":"11","author":[{"given":"Taku","family":"Ogawa","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522 Japan . Tel: +81-744-22-3051 (ext. 3525); Fax: +81-744-24-9212"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukumi","family":"Uchiyama-Nakamura","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Nara Medical University, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Sugata-Tsubaki","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Nara Medical University, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yamada","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Nara Medical University, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Uno","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Nara Medical University, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Nara Medical University, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Nara Medical University, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Konishi","sequence":"additional","affiliation":[{"name":"Health Management Center, Nara Medical University, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Mikasa","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Nara Medical University, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2016,11,26]]},"reference":[{"key":"2023040102562810240_j_med-2016-0085_ref_001_w2aab3b8d280b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Gans H, Yasukawa L, Rinki M, et al. Immune responses to measles and mumps vaccination of infants at 6, 9, and 12 months. J Infect Dis., 2001, 184:817-826","DOI":"10.1086\/323346"},{"key":"2023040102562810240_j_med-2016-0085_ref_002_w2aab3b8d280b1b7b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Shishido A, Ohtawara M. Development of attenuated rubella virus vaccines in Japan. Jpn J Med Sci Biol., 1976, 29, 227-253","DOI":"10.7883\/yoken1952.29.227"},{"key":"2023040102562810240_j_med-2016-0085_ref_003_w2aab3b8d280b1b7b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Seward JF, Marin M, V\u00e1zquez M. Varicella vaccine effectiveness in the US vaccination program: a review. J Infect Dis., 2008, 197, S82-S89","DOI":"10.1086\/522145"},{"key":"2023040102562810240_j_med-2016-0085_ref_004_w2aab3b8d280b1b7b1ab2b1b4Aa","unstructured":"Centers for Disease Control and Prevention (CDC). Progress toward measles elimination-Japan, 1999-2008. 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