{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:23:45Z","timestamp":1772191425038,"version":"3.50.1"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_med-2017-0046_s_006_w2aab2b8d248b1b7b1aab1c16b1Aa\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect and toxicity of alprostadil combined with thioctic acid injection in the treatment of patients with diabetic nephropathy (DN).<\/jats:p><\/jats:sec><jats:sec id=\"j_med-2017-0046_s_007_w2aab2b8d248b1b7b1aab1c16b2Aa\"><jats:title>Methods<\/jats:title><jats:p>Sixty two patients with DN were included in this study and randomly divided into control group (n=32) and experiment group (n=30). Patients in the control group were given alprostadil 20ug+NS 100ml ivgtt, qd and patients in the experiment group were given alprostadil 20ug+NS 100ml ivgtt combined with thioctic acid injection of 0.45g+100ml ivgtt, qd for 14 days. After treatment, the renal function and serum level of CRP, IL-6 and TNF-\u03b1 were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec id=\"j_med-2017-0046_s_008_w2aab2b8d248b1b7b1aab1c16b3Aa\"><jats:title>Results<\/jats:title><jats:p>After two weeks of treatment, the serum level of CysC and UAER significant decreased for both control and experiment group with statistical difference of p&lt;0.05. After treatment, the serum level of CysC were 1.40 \u00b10.46 mg\/L and 1.02\u00b10.33 for control and experiment group respectively (p&lt;0.05). The post-treatment UAER in experiment group was significantly lower than those of control group with statistical difference (81.02\u00b10.33 vs112.45\u00b120.32, p&lt;0.05) ug\/min. The serum level of CRP, IL-6 and TNF-\u03b1 were significantly decreased after treatment for both control and experiment group (p&lt;0.05). And the post-treatment serum CRP, IL-6 and TNF-\u03b1 in experiment group were significantly lower than those of control group with statistical difference (p&lt;0.05). No significant side effects were found for the two groupsin the course of treatment.<\/jats:p><\/jats:sec><jats:sec id=\"j_med-2017-0046_s_009_w2aab2b8d248b1b7b1aab1c16b4Aa\"><jats:title>Conclusion<\/jats:title><jats:p>Alprostadil combined with \u03b1-lipoic acid may improve renal function in patients with diabetic nephropathy by decreasing the levels of serum inflammatory factors.<\/jats:p><\/jats:sec>","DOI":"10.1515\/med-2017-0046","type":"journal-article","created":{"date-parts":[[2017,10,8]],"date-time":"2017-10-08T10:01:30Z","timestamp":1507456890000},"page":"323-327","source":"Crossref","is-referenced-by-count":12,"title":["Clinical efficacy of alprostadil combined with \u03b1-lipoic acid in the treatment of elderly patients with diabetic nephropathy"],"prefix":"10.1515","volume":"12","author":[{"given":"Yan","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Pharmacy , The fifth Affiliated Hospital of Wenzhou Medical University , Lishui Central Hospital , Lishui Zhejiang Province 323000 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Nephrology , The sixth Affiliated Hospital of Wenzhou Medical University , People\u2018s Hospital of Lishui City , Lishui Zhejiang Province 323000 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Respiratory , The sixth Affiliated Hospital of Wenzhou Medical University , People\u2018s Hospital , Lishui City , Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology , The sixth Affiliated Hospital of Wenzhou Medical University , People\u2018s Hospital of Lishui City , Lishui Zhejiang Province 323000 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Nephrology , The sixth Affiliated Hospital of Wenzhou Medical University , People\u2018s Hospital of Lishui City , Lishui Zhejiang Province 323000 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lejian","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Nephrology , The sixth Affiliated Hospital of Wenzhou Medical University , People\u2018s Hospital of Lishui City , Lishui Zhejiang Province 323000 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"2022042708270250991_j_med-2017-0046_ref_001_w2aab2b8d248b1b7b1ab2b1b1Aa","unstructured":"Kitada M, Koya D. 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