{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:24:00Z","timestamp":1792686240294,"version":"4.5.0"},"reference-count":41,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) are diseases that occur only in preterm infants. The etiology of these disorders is multifactorial; however, it is believed that some of the factors in children presenting with BPD affect both the initiation and severity of ROP. The aim of the study was to evaluate the degree of clinical severity of ROP in infants with BPD compared to those without BPD.<\/jats:p><jats:sec id=\"j_med-2018-0012_s_005_w2aab3b7d135b1b6b1aab1c15b2Aa\"><jats:title>Methodology<\/jats:title><jats:p>Infants were divided into two groups: the BPD+ study group and BPD- control group. Parameters including the incidence of ROP and its severity were compared.<\/jats:p><\/jats:sec><jats:sec id=\"j_med-2018-0012_s_006_w2aab3b7d135b1b6b1aab1c15b3Aa\"><jats:title>Results<\/jats:title><jats:p>In neonates with BPD, more severe forms of ROP occurred significantly more frequently than in infants without BPD. Newborns with BPD required significantly longer use of mechanical ventilation; moreover, the number of days in which the concentration of oxygen in the respiratory mixture exceeded 50% was greater in BPD+ children . Children with BPD also received more blood transfusions compared to children without BPD.<\/jats:p><\/jats:sec><jats:sec id=\"j_med-2018-0012_s_007_w2aab3b7d135b1b6b1aab1c15b4Aa\"><jats:title>Conclusions<\/jats:title><jats:p>Newborns in the BPD+ study group showed advanced stages of ROP more often than newborns in the BPD- control group. The etiology of ROP and BPD is multifactorial; however, our findings suggest oxygen plays a significant role in the development of these diseases.<\/jats:p><\/jats:sec>","DOI":"10.1515\/med-2018-0012","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T22:17:19Z","timestamp":1522275439000},"page":"67-73","source":"Crossref","is-referenced-by-count":31,"title":["Correlation of retinopathy of prematurity with bronchopulmonary dysplasia"],"prefix":"10.1515","volume":"13","author":[{"given":"Wojciech","family":"Podraza","sequence":"first","affiliation":[{"name":"Department of Medical Physics , ul. Ku Sloncu 12, 71-073 , Szczecin , Poland , Tel.: + 48 91 441 4520; mobile: + 48 602106702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Michalczuk","sequence":"additional","affiliation":[{"name":"Department of Medical Physics , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Jezierska","sequence":"additional","affiliation":[{"name":"Department of Medical Physics , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Domek","sequence":"additional","affiliation":[{"name":"Department of Medical Physics , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kordek","sequence":"additional","affiliation":[{"name":"Department of Neonatal Diseases , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"\u0141oniewska","sequence":"additional","affiliation":[{"name":"Department of Neonatal Diseases , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Modrzejewska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kot","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,3,21]]},"reference":[{"key":"2022042708343405192_j_med-2018-0012_ref_001_w2aab3b7d135b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Hellstr\u00f6m A, Smith LE, Dammann O. Retinopathy of prematurity. Lancet 2013;382:1445-1457","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"2022042708343405192_j_med-2018-0012_ref_002_w2aab3b7d135b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Isaza G, Arora S, Bal M, Chaudhary V. Incidence of retinopathy of prematurity and risk factors among premature infants at a neonatal intensive care unit in Canada. Journal of Pediatric Ophthalmology and Strabismus 2013;50:27-32","DOI":"10.3928\/01913913-20121127-02"},{"key":"2022042708343405192_j_med-2018-0012_ref_003_w2aab3b7d135b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"EXPRESS Group. Incidence of and risk factors for neonatal morbidity after active perinatal care: extremely preterm infants study in Sweden (EXPRESS). Acta Paediatrica 2010;99:978-992","DOI":"10.1111\/j.1651-2227.2010.01846.x"},{"key":"2022042708343405192_j_med-2018-0012_ref_004_w2aab3b7d135b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Bizzarro MJ, Li FY, Katz K, Shabanova V, Ehrenkranz RA, Bhandari V. Temporal quantification of oxygen saturation ranges: an effort to reduce hyperoxia in the neonatal intensive care unit. Journal of Perinatology 2014;34:33-38","DOI":"10.1038\/jp.2013.122"},{"key":"2022042708343405192_j_med-2018-0012_ref_005_w2aab3b7d135b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Del Vecchio A, Henry E, D\u2019Amato G, Cannuscio A, Corriero L, Motta M, et al. Instituting a program to reduce the erythrocyte transfusion rate was accompanied by reductions in the incidence of bronchopulmonary dysplasia, retinopathy of prematurity and necrotizing enterocolitis. The Journal of Maternal-Fetal & Neonatal Medicine 2013;26 Suppl 2:77-79","DOI":"10.3109\/14767058.2013.830836"},{"key":"2022042708343405192_j_med-2018-0012_ref_006_w2aab3b7d135b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Fortes Filho JB, Eckert GU, Valiatti FB, Dos Santos PG, da Costa MC, Procianoy RS. The influence of gestational age on the dynamic behavior of other risk factors associated with retinopathy of prematurity (ROP). Graefe\u2019s Archive for Clinical and Experimental Ophthalmology 2010;248:893-900","DOI":"10.1007\/s00417-009-1248-6"},{"key":"2022042708343405192_j_med-2018-0012_ref_007_w2aab3b7d135b1b6b1ab2b1b7Aa","doi-asserted-by":"crossref","unstructured":"Stancheva VP, Sherman GG, Avent M, Cory BJ, Ballot DE, Cooper PA. Hematological reference ranges in black very low birth weight infants. Pediatric Hematology and Oncology 2002;19:91-94","DOI":"10.1080\/08880010252825678"},{"key":"2022042708343405192_j_med-2018-0012_ref_008_w2aab3b7d135b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Rivera JC, Sapieha P, Joyal JS, Duhamel F, Shao Z, Sitaras N, et al. Understanding retinopathy of prematurity: update on pathogenesis. Neonatology 2011;100:343-353","DOI":"10.1159\/000330174"},{"key":"2022042708343405192_j_med-2018-0012_ref_009_w2aab3b7d135b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Garg U, Jain A, Singla P, Beri S, Garg R, Saili A. Free radical status in retinopathy of prematurity. Indian Journal of Clinical Biochemistry 2012;27:196-199","DOI":"10.1007\/s12291-011-0180-9"},{"key":"2022042708343405192_j_med-2018-0012_ref_010_w2aab3b7d135b1b6b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Csak K, Szabo V, Szabo A, Vannay A. Pathogenesis and genetic basis for retinopathy of prematurity. Frontiers in Bioscience 2006;11:908-920","DOI":"10.2741\/1847"},{"key":"2022042708343405192_j_med-2018-0012_ref_011_w2aab3b7d135b1b6b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Shastry BS. Genetic susceptibility to advanced retinopathy of prematurity (ROP). Journal of Biomedical Science 2010;17:69","DOI":"10.1186\/1423-0127-17-69"},{"key":"2022042708343405192_j_med-2018-0012_ref_012_w2aab3b7d135b1b6b1ab2b1c12Aa","doi-asserted-by":"crossref","unstructured":"Mahlman M, Huusko JM, Karjalainen MK, Kaukola T, Marttila R, Ojaniemi M, et al. Gen-BPD Study Group. Genes Encoding Vascular Endothelial Growth Factor A (VEGF-A) and VEGF Receptor 2 (VEGFR-2) and Risk for Bronchopulmonary Dysplasia. Neonatology 2015;108:53-59","DOI":"10.1159\/000381279"},{"key":"2022042708343405192_j_med-2018-0012_ref_013_w2aab3b7d135b1b6b1ab2b1c13Aa","doi-asserted-by":"crossref","unstructured":"Dickinson JL, Sale MM, Passmore A, FitzGerald LM, Wheatley CM, Burdon KP, et al. Mutations in the NDP gene: contribution to Norrie disease, familial exudative vitreoretinopathy and retinopathy of prematurity. Clinical & Experimental Ophthalmolmology 2006;34:682-688","DOI":"10.1111\/j.1442-9071.2006.01314.x"},{"key":"2022042708343405192_j_med-2018-0012_ref_014_w2aab3b7d135b1b6b1ab2b1c14Aa","doi-asserted-by":"crossref","unstructured":"Poggi C, Giusti B, Gozzini E, Sereni A, Romagnuolo I, Kura A, et al. Genetic Contributions to the Development of Complications in Preterm Newborns. PLoS One. 2015 Jul 14;10(7):e0131741. 10.1371\/journal.pone.0131741. eCollection 2015","DOI":"10.1371\/journal.pone.0131741"},{"key":"2022042708343405192_j_med-2018-0012_ref_015_w2aab3b7d135b1b6b1ab2b1c15Aa","doi-asserted-by":"crossref","unstructured":"Kusuda T, Hikino S, Ohga S, Kinjo T, Ochiai M, Takahata Y, et al. Genetic variation of vascular endothelial growth factor pathway does not correlate with the severity of retinopathy of prematurity. Journal of Perinatology. 2011;31:246-250","DOI":"10.1038\/jp.2010.111"},{"key":"2022042708343405192_j_med-2018-0012_ref_016_w2aab3b7d135b1b6b1ab2b1c16Aa","doi-asserted-by":"crossref","unstructured":"Raghuveer TS, Bloom BT. A paradigm shift in the prevention of retinopathy of prematurity. Neonatology 2011;100:116-129","DOI":"10.1159\/000322848"},{"key":"2022042708343405192_j_med-2018-0012_ref_017_w2aab3b7d135b1b6b1ab2b1c17Aa","doi-asserted-by":"crossref","unstructured":"Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of myaline membrane disease: bronchopulmonary dysplasia. The New England Journal of Medicine 1967;276:357-368","DOI":"10.1056\/NEJM196702162760701"},{"key":"2022042708343405192_j_med-2018-0012_ref_018_w2aab3b7d135b1b6b1ab2b1c18Aa","doi-asserted-by":"crossref","unstructured":"Jobe AH, Bancalari E. Bronchopulmonary dysplasia. American Journal of Respiratory and Critical Care Medicine 2001;163:1723-1729","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"2022042708343405192_j_med-2018-0012_ref_019_w2aab3b7d135b1b6b1ab2b1c19Aa","doi-asserted-by":"crossref","unstructured":"Bhandari V. Postnatal inflammation in the pathogenesis of bronchopulmonary dysplasia. Birth Defects Research Part A: Clinical and Molecular Teratology 2014;100:189-201","DOI":"10.1002\/bdra.23220"},{"key":"2022042708343405192_j_med-2018-0012_ref_020_w2aab3b7d135b1b6b1ab2b1c20Aa","doi-asserted-by":"crossref","unstructured":"Mulder EE, Lopriore E, Rijken M, Walther FJ, te Pas AB. Changes in respiratory support of preterm infants in the last decade: are we improving? Neonatology 2012;101:247-253","DOI":"10.1159\/000334591"},{"key":"2022042708343405192_j_med-2018-0012_ref_021_w2aab3b7d135b1b6b1ab2b1c21Aa","doi-asserted-by":"crossref","unstructured":"Guven S, Bozdag S, Saner H, Cetinkaya M, Yazar AS, Erguven M. Early neonatal outcomes of volume guaranteed ventilation in preterm infants with respiratory distress syndrome. The Journal of Maternal-Fetal and Neonatal Medicine 2013;26:396-401","DOI":"10.3109\/14767058.2012.733778"},{"key":"2022042708343405192_j_med-2018-0012_ref_022_w2aab3b7d135b1b6b1ab2b1c22Aa","doi-asserted-by":"crossref","unstructured":"Gien J, Kinsella JP. Pathogenesis and treatment of bronchopulmonary dysplasia. Current Opinion in Pediatrics 2011;23:305-313","DOI":"10.1097\/MOP.0b013e328346577f"},{"key":"2022042708343405192_j_med-2018-0012_ref_023_w2aab3b7d135b1b6b1ab2b1c23Aa","doi-asserted-by":"crossref","unstructured":"International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Archives of Ophthalmology. 2005;123:991-999","DOI":"10.1001\/archopht.123.7.991"},{"key":"2022042708343405192_j_med-2018-0012_ref_024_w2aab3b7d135b1b6b1ab2b1c24Aa","unstructured":"Kornacka MK, Tupieka A, Czajka I, Gajewska M, Go\u0142\u0119biewska E. Stopie\u0144 utlenowania krwi noworodk\u00f3w z mas\u0105 cia\u0142a < 1250 g a cz\u0119sto\u015b\u0107 retinopatii. Ginekologia Polska 2003;74:538-544"},{"key":"2022042708343405192_j_med-2018-0012_ref_025_w2aab3b7d135b1b6b1ab2b1c25Aa","doi-asserted-by":"crossref","unstructured":"Holmstr\u00f6m G, Broberger U, Thomassen P. Neonatal risk factors for retinopathy of prematurity \u2013 a population-based study. Acta Ophthalmologica Scandinavica 1998;76:204-207","DOI":"10.1034\/j.1600-0420.1998.760216.x"},{"key":"2022042708343405192_j_med-2018-0012_ref_026_w2aab3b7d135b1b6b1ab2b1c26Aa","doi-asserted-by":"crossref","unstructured":"Higgins RD, Mendelsohn AL, DeFeo MJ. Antenatal dexamethasone and decreased severity of retinopathy of prematurity. Archives of Ophthalmology 1998;116:601-605","DOI":"10.1001\/archopht.116.5.601"},{"key":"2022042708343405192_j_med-2018-0012_ref_027_w2aab3b7d135b1b6b1ab2b1c27Aa","doi-asserted-by":"crossref","unstructured":"Leviton A, Dammann O, Engelke S, Allred E, Kuban KC, O\u2019Shea TM, et al. ELGAN study investigators. The clustering of disorders in infants born before the 28th week of gestation. Acta Paediatrica 2010;99:1795-1800","DOI":"10.1111\/j.1651-2227.2010.01973.x"},{"key":"2022042708343405192_j_med-2018-0012_ref_028_w2aab3b7d135b1b6b1ab2b1c28Aa","unstructured":"Krzysztofowicz A, Pilarczyk E, Kozak-Tuleta U, Szkar\u0142at A, Mrozi\u0144ska M, Bielawska-Sowa A. Wyst\u0119powanie retinopatii u wcze\u015bniak\u00f3w leczonych w Oddziale Intensywnej Terapii i Patologii Noworodka w Szpitalu Specjalistycznym w Gda\u0144sku w latach 2003-2006. Post\u0119py Neonatologii 2007;2:95-99"},{"key":"2022042708343405192_j_med-2018-0012_ref_029_w2aab3b7d135b1b6b1ab2b1c29Aa","doi-asserted-by":"crossref","unstructured":"Shah VA, Yeo CL, Ling YLF, Ho LY. Incidence, risk factor of retinopathy of prematurity among very low birth weight infants in Singapore. Annals of the Academy of Medicine , Singapore 2005;34:169-178","DOI":"10.47102\/annals-acadmedsg.V34N2p169"},{"key":"2022042708343405192_j_med-2018-0012_ref_030_w2aab3b7d135b1b6b1ab2b1c30Aa","doi-asserted-by":"crossref","unstructured":"Allegaert K, de Coen K, Devlieger H. Threshold retinopathy at threshold of viability: the EpiBel study. The British Journal of Ophthalmology 2004;88:239-242","DOI":"10.1136\/bjo.2003.027474"},{"key":"2022042708343405192_j_med-2018-0012_ref_031_w2aab3b7d135b1b6b1ab2b1c31Aa","unstructured":"Yang CS, Chen SJ, Lee FL, Hsu WM, Liu JH. Retinopathy of prematurity: screening, incidence and risk factor analysis. Chinese Medical Journal 2002;64:706-712"},{"key":"2022042708343405192_j_med-2018-0012_ref_032_w2aab3b7d135b1b6b1ab2b1c32Aa","doi-asserted-by":"crossref","unstructured":"Seiberth V, Linderkamp O. Risk factors in retinopathy of prematurity. A multivariate statistical analysis. Ophthalmologica 2000;214:131-135","DOI":"10.1159\/000027482"},{"key":"2022042708343405192_j_med-2018-0012_ref_033_w2aab3b7d135b1b6b1ab2b1c33Aa","doi-asserted-by":"crossref","unstructured":"Perrone S, Tataranno ML, Negro S, Longini M, Marzocchi B, Proietti F, et al. Early identification of the risk for free radical-related diseases in preterm newborns. Early Human Development 2010;86:241-244","DOI":"10.1016\/j.earlhumdev.2010.03.008"},{"key":"2022042708343405192_j_med-2018-0012_ref_034_w2aab3b7d135b1b6b1ab2b1c34Aa","doi-asserted-by":"crossref","unstructured":"Stenson BJ, Tarnow-Mordi WO, Darlow BA, Simes J, Juszczak E, Askie L, et al. Oxygen saturation and outcomes in preterm infants. The New England Journal of Medicine. 2013;368:2094-2104","DOI":"10.1056\/NEJMoa1302298"},{"key":"2022042708343405192_j_med-2018-0012_ref_035_w2aab3b7d135b1b6b1ab2b1c35Aa","doi-asserted-by":"crossref","unstructured":"Hair AB, Peluso AM, Hawthorne KM, Perez J, Smith DP, Khan JY, et al. Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk-Based Diet. Breastfeeding Medicine. 2016;11:70-74","DOI":"10.1089\/bfm.2015.0134"},{"key":"2022042708343405192_j_med-2018-0012_ref_036_w2aab3b7d135b1b6b1ab2b1c36Aa","doi-asserted-by":"crossref","unstructured":"Poon AW, Ma EX, Vadivel A, Jung S, Khoja Z, Stephens L, et al. Impact of bronchopulmonary dysplasia on brain and retina. Biology Open. 2016;5:475-483","DOI":"10.1242\/bio.017665"},{"key":"2022042708343405192_j_med-2018-0012_ref_037_w2aab3b7d135b1b6b1ab2b1c37Aa","doi-asserted-by":"crossref","unstructured":"Englert JA, Saunders RA, Purohit D. The effect of anemia on retinopathy of prematurity in extremely low birth weight infants. Journal of Perinatology 2001;21:21-26","DOI":"10.1038\/sj.jp.7200511"},{"key":"2022042708343405192_j_med-2018-0012_ref_038_w2aab3b7d135b1b6b1ab2b1c38Aa","doi-asserted-by":"crossref","unstructured":"Mehta R, Nanjundaswamy S, Shen-Schwarz S, Petrova A. Neonatal morbidity and placental pathology. Indian Journal of Pediatrics 2006;73:25-28","DOI":"10.1007\/BF02758255"},{"key":"2022042708343405192_j_med-2018-0012_ref_039_w2aab3b7d135b1b6b1ab2b1c39Aa","doi-asserted-by":"crossref","unstructured":"Hartling L, Liang Y, Lacaze-Masmonteil T. Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis. Archives of Disease in Childhood - Fetal and Neonatal Edition 2012;97:8-17","DOI":"10.1136\/adc.2010.210187"},{"key":"2022042708343405192_j_med-2018-0012_ref_040_w2aab3b7d135b1b6b1ab2b1c40Aa","doi-asserted-by":"crossref","unstructured":"Lacaze-Masmonteil T. That chorioamnionitis is a risk factor for bronchopulmonary dysplasia - the case against. Paediatric Respiratory Reviews. 2014;15:53-55","DOI":"10.1016\/j.prrv.2013.09.005"},{"key":"2022042708343405192_j_med-2018-0012_ref_041_w2aab3b7d135b1b6b1ab2b1c41Aa","doi-asserted-by":"crossref","unstructured":"Higgins RD, Saade G, Polin RA, Grobman WA, Buhimschi IA, Watterberg K, et al. Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop. Obstetrics and Gynecology 2016; 127: 426-436","DOI":"10.1097\/AOG.0000000000001246"}],"container-title":["Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/med\/13\/1\/article-p67.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2018-0012\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2018-0012\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T12:03:08Z","timestamp":1719921788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2018-0012\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,3,15]]},"published-print":{"date-parts":[[2018,3,15]]}},"alternative-id":["10.1515\/med-2018-0012"],"URL":"https:\/\/doi.org\/10.1515\/med-2018-0012","relation":{},"ISSN":["2391-5463"],"issn-type":[{"value":"2391-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]}}}