{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:09:01Z","timestamp":1777727341675,"version":"3.51.4"},"reference-count":6,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Signet ring B cell lymphoma is an unusual non-Hodgkin lymphoma. It is similar to signet ring cell carcinoma and liposarcoma in morphology which should be distinguished. We treated a 63-year-old male patient who suffered from abdominal pain for two months. Multiple enlarged lymph nodes were found in the retroperitoneum by CT scan. The needle biopsy showed neoplastic cells distributed uniformly with clear cytoplasm and the nucleus squeezed to the side mimicking the appearance of signet ring in morphology. By special staining, the neoplastic cells were positive for CD45, Vimentin, Bcl-2 and CD20 but negative for AE1\/AE3, S-100, CD3, EMA, CD5, CD10, Bcl-6, MUM1 , Kappa, Lambda and PAS . Ki67 proliferation index was much more than 80%. Based on the histological characters, a diagnosis of signet ring B cell lymphoma was made. Although the patient received six courses of R-CHOP therapy, he died of tumor recurrence at the 34th month after diagnosis.<\/jats:p>","DOI":"10.1515\/med-2019-0033","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T05:22:51Z","timestamp":1555564971000},"page":"343-345","source":"Crossref","is-referenced-by-count":5,"title":["Signet ring B cell lymphoma: A potential diagnostic pitfall"],"prefix":"10.1515","volume":"14","author":[{"given":"Shishou","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Clinical Medcine, Binzhou Medical College , No.346, Guanhai Road , Yantai , China"},{"name":"Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University , Yantai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Medicine, Affiliated Yantai Yuhuangding Hospital, Qingdao University , Yantai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University , Yantai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University , Yantai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medicine, Affiliated Yantai Yuhuangding Hospital, Qingdao University , Yantai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University , Yantai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,4,13]]},"reference":[{"key":"2026012107363618688_j_med-2019-0033_ref_001","doi-asserted-by":"crossref","unstructured":"Tungekar MF. Gastric signet-ring cell lymphoma with alpha heavy chains. Histopathology. 1986,10, 725-733","DOI":"10.1111\/j.1365-2559.1986.tb02526.x"},{"key":"2026012107363618688_j_med-2019-0033_ref_002","doi-asserted-by":"crossref","unstructured":"Weiss LM, Wood GS, Dorfman RF. T-cell signet-ring cell lymphoma. A histologic, ultrastructural, and immunohistochemical study of two cases. Am J Surg Pathol. 1985, 9, 273-280","DOI":"10.1097\/00000478-198504000-00003"},{"key":"2026012107363618688_j_med-2019-0033_ref_003","doi-asserted-by":"crossref","unstructured":"George SA, Junaid TA. Gastric marginal zone lymphoma of mucosa-associated lymphoid tissue and signet ring cell carcinoma, synchronous collision tumour of the stomach: a case report. Med Princ Pract. 2014, 23, 377-379","DOI":"10.1159\/000356180"},{"key":"2026012107363618688_j_med-2019-0033_ref_004","doi-asserted-by":"crossref","unstructured":"Wang J, Katz RL, Stewart J, Landon G, Guo M, Gong Y. Fine-needle aspiration diagnosis of lymphomas with signet ring cell features: potential pitfalls and solutions. Cancer Cytopathol. 2013, 121, 525-532","DOI":"10.1002\/cncy.21291"},{"key":"2026012107363618688_j_med-2019-0033_ref_005","doi-asserted-by":"crossref","unstructured":"Gore CR, Panicker NK, Kumar H, Buch A, Chandanwale SS. A rare case of signet ring cell lymphoma: Diagnosis aided by immunofluorescent staining. J Cytol. 2017, 34, 56-58","DOI":"10.4103\/0970-9371.197622"},{"key":"2026012107363618688_j_med-2019-0033_ref_006","doi-asserted-by":"crossref","unstructured":"Sakai K, Yamasaki N, Notohara K, Ueda Y. Signet ring cell \"lymphoma\": mimicking the appearance of signet ring cell carcinoma.Int J Hematol. 2016, 103, 481-482","DOI":"10.1007\/s12185-016-1983-5"}],"container-title":["Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/med\/14\/1\/article-p343.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/med-2019-0033\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/med-2019-0033\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:38:22Z","timestamp":1768981102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/med-2019-0033\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,16]]},"published-print":{"date-parts":[[2019,1,16]]}},"alternative-id":["10.1515\/med-2019-0033"],"URL":"https:\/\/doi.org\/10.1515\/med-2019-0033","relation":{},"ISSN":["2391-5463"],"issn-type":[{"value":"2391-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]}}}