{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T19:28:28Z","timestamp":1682796508438},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 62-year-old male who was receiving prednisolone and methotrexate for scleroderma and rheumatoid arthritis complained of diarrhea and vomiting, and was transferred to our hospital for detailed examination and treatment of renal dysfunction and thrombocytopenia. Hemolytic anemia and crushed erythrocytes were found during the patient\u2019s course; therefore, we suspected thrombotic microangiopathy (TMA). His ADAMTS13 activity was 60.3% and his ADAMTS13 inhibitor was under 0.5. In addition, his blood culture was positive for <jats:italic>Streptococcus pneumoniae<\/jats:italic>, and we finally diagnosed <jats:italic>Streptococcus pneumoniae<\/jats:italic>-associated TMA (pTMA). The patient was treated with antibiotics and hemodialysis. The patient recovered and was discharged on the 45<jats:sup>th<\/jats:sup> hospital day. Adult pTMA cases are remarkably rare. We herein report a successfully treated adult case of pTMA.<\/jats:p>","DOI":"10.1515\/med-2020-0030","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T09:03:50Z","timestamp":1584608630000},"page":"204-210","source":"Crossref","is-referenced-by-count":4,"title":["<i>Streptococcus pneumoniae<\/i>-associated thrombotic microangiopathy in an immunosuppressed adult"],"prefix":"10.1515","volume":"15","author":[{"given":"Yumi","family":"Ichikawa","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Gunma University Graduate School of Medicine , 3-19-15 Showamachi, Maebashi, 371-8511 , Gunma , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Gunma University Graduate School of Medicine , 3-19-15 Showamachi, Maebashi, 371-8511 , Gunma , Japan"},{"name":"Emergency Medical Center, Gunma University Hospital , 3-19-15 Showa-machi, Maebashi, 371-8511 , Gunma , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Gunma University Graduate School of Medicine , 3-19-15 Showamachi, Maebashi, 371-8511 , Gunma , Japan"},{"name":"Emergency Medical Center, Gunma University Hospital , 3-19-15 Showa-machi, Maebashi, 371-8511 , Gunma , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Gunma University Graduate School of Medicine , 3-19-15 Showamachi, Maebashi, 371-8511 , Gunma , Japan"},{"name":"Emergency Medical Center, Gunma University Hospital , 3-19-15 Showa-machi, Maebashi, 371-8511 , Gunma , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Isshiki","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Gunma University Graduate School of Medicine , 3-19-15 Showamachi, Maebashi, 371-8511 , Gunma , Japan"},{"name":"Emergency Medical Center, Gunma University Hospital , 3-19-15 Showa-machi, Maebashi, 371-8511 , Gunma , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Gunma University Graduate School of Medicine , 3-19-15 Showamachi, Maebashi, 371-8511 , Gunma , Japan"},{"name":"Emergency Medical Center, Gunma University Hospital , 3-19-15 Showa-machi, Maebashi, 371-8511 , Gunma , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Gunma University Graduate School of Medicine , 3-19-15 Showamachi, Maebashi, 371-8511 , Gunma , Japan"},{"name":"Emergency Medical Center, Gunma University Hospital , 3-19-15 Showa-machi, Maebashi, 371-8511 , Gunma , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohiro","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Gunma University Graduate School of Medicine , 3-19-15 Showamachi, Maebashi, 371-8511 , Gunma , Japan"},{"name":"Emergency Medical Center, Gunma University Hospital , 3-19-15 Showa-machi, Maebashi, 371-8511 , Gunma , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"key":"2022042711563127340_j_med-2020-0030_ref_001_w2aab3b7d193b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Vanderkooi O.G., Kellner J.D., Wade A.W., Jadavji T., Midgley J.P., Louie T., et al, Invasive Streptococcus pneumoniae infection causing hemolytic uremic syndrome in children: Two recent cases, Can J Infect Dis, 2003, 14(6), 339\u2013343; DOI: 10.1155\/2003\/219027","DOI":"10.1155\/2003\/219027"},{"key":"2022042711563127340_j_med-2020-0030_ref_002_w2aab3b7d193b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Kato, H., Nangaku, M., Hataya, H., Sawai, T., Ashida, A., Fujimaru, R., et al., Clinical guides for atypical hemolytic uremic syndrome in Japan, Clin Exp Nephrol, 2016, 20(4), 536\u2013543; DOI: 10.1007\/s10157-016-1276-6","DOI":"10.1007\/s10157-016-1276-6"},{"key":"2022042711563127340_j_med-2020-0030_ref_003_w2aab3b7d193b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Goodship, T. 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