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We studied 35 patients with cardiac death and suspected cardiomyopathy based on autopsy or clinical data. After targeted sequencing, we identified 15 causal variants in 15 patients (yield 43%) in sarcomeric (<jats:italic>n<\/jats:italic> = 8), desmosomal (<jats:italic>n<\/jats:italic> = 3), lamin A\/C (<jats:italic>n<\/jats:italic> = 3) and transthyretin (<jats:italic>n<\/jats:italic> = 1) genes. The results had various impacts on families, i.e. allowed predictive genetic testing in relatives (15 families), planned early therapeutics based on the specific underlying gene (5 families), rectified the suspected cardiomyopathy subtype (2 families), assessed the genetic origin of cardiomyopathy that usually has an acquired cause (1 family), assessed the diagnosis in a patient with uncertain borderline cardiomyopathy (1 family), reassured the siblings because of a <jats:italic>de novo<\/jats:italic> mutation (2 families) and allowed prenatal testing (1 family). Our findings suggest that post-mortem molecular testing should be included in the strategy of family care after cardiac death and suspected cardiomyopathy, since genetic findings provide additional information useful for relatives, which are beyond conventional autopsy.<\/jats:p>","DOI":"10.1515\/med-2020-0150","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T14:43:39Z","timestamp":1590504219000},"page":"435-446","source":"Crossref","is-referenced-by-count":22,"title":["Clinical impact of post-mortem genetic testing in cardiac death and cardiomyopathy"],"prefix":"10.1515","volume":"15","author":[{"given":"Isabelle","family":"Marey","sequence":"first","affiliation":[{"name":"APHP , Reference Center f or Hereditary Heart Diseases , Department of Genetics , Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 75013 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Fressart","sequence":"additional","affiliation":[{"name":"APHP , Cardiogenetics and Myogenetics Unit , Metabolic Biochemistry Department , Piti\u00e9-Salp\u00eatri\u00e8re Hospital Group , 75013 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Rambaud","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine , Raymond Poincar\u00e9 Hospital , APHP , UVSQ , 92380 Garches , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fornes","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine , Reims Hospital , 51100 Reims , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine , Dijon Hospital , 21000 Dijon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Grotto","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics , Robert Debr\u00e9 Hospital , 75019 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Alembik","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics , Strasbourg-Hautepierre Hospital , 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Gorka","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Chartres Hospital , 28000 Chartres , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Millat","sequence":"additional","affiliation":[{"name":"Molecular Cardiogenetics Laboratory , Center for Biology and Pathology East , Hospices Civils de Lyon , 69500 Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Gandjbakhch","sequence":"additional","affiliation":[{"name":"APHP , Reference Center f or Hereditary Heart Diseases , Department of Genetics , Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 75013 Paris , France"},{"name":"Sorbonne Universit\u00e9 , INSERM , UMR_S 1166 , ICAN Institute for Cardiometabolism and Nutrition , 75013 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Bordet","sequence":"additional","affiliation":[{"name":"APHP , Reference Center f or Hereditary Heart Diseases , Department of Genetics , Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 75013 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy Lorin de la","family":"Grandmaison","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine , Raymond Poincar\u00e9 Hospital , APHP , UVSQ , 92380 Garches , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Richard","sequence":"additional","affiliation":[{"name":"APHP , Cardiogenetics and Myogenetics Unit , Metabolic Biochemistry Department , Piti\u00e9-Salp\u00eatri\u00e8re Hospital Group , 75013 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Charron","sequence":"additional","affiliation":[{"name":"APHP , Reference Center f or Hereditary Heart Diseases , Department of Genetics , Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 75013 Paris , France"},{"name":"Sorbonne Universit\u00e9 , INSERM , UMR_S 1166 , ICAN Institute for Cardiometabolism and Nutrition , 75013 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"2022052423154226210_j_med-2020-0150_ref_001_w2aab3b7d359b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, et al. 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