{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:12:11Z","timestamp":1759709531904},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this study was to evaluate the clinicopathological features and treatment of composite lymphoma (CL) with cervical lymph node enlargement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, two cases of CL are presented. Biopsies of enlarged cervical lymph nodes by excision revealed two distinct types of lymphomas. The diagnoses were confirmed by routine histopathology, immunohistochemistry, <jats:italic>in situ<\/jats:italic> hybridization, polymerase chain reactions and flow cytometry. Case 1 was diagnosed with Hodgkin\u2019s lymphoma and cytotoxic T-cell lymphoma complicated by Epstein\u2013Barr virus infection. Case 2 was diagnosed with diffuse large B-cell lymphoma and angioimmunoblastic T-cell lymphoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Case 1 received one cycle of adriamycin, bleomycin, vincristine and dacarbazine (ABVD regimen) combined with chidamide, followed by one cycle of gemcitabine and dexamethasone (GDP regimen) combined with chidamide, and then oral acyclovir. The patient achieved stable disease, but was lost to follow-up. Case 2 received eight cycles of cyclophosphamide, pirarubicin, vincristine and dexamethasone (CTOP regimen) combined with chidamide, and the patient achieved complete remission. Nine months later, relapse was confirmed. She received chidamide monotherapy for 3 months, which was then terminated. One year later, the patient underwent progressive disease and died.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CL is a kind of rare disease. Due to the complexity of CL, clinicians should consider both disease components in order to increase the likelihood of effective treatment. This is important.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/med-2020-0191","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T11:49:32Z","timestamp":1594640972000},"page":"654-658","source":"Crossref","is-referenced-by-count":6,"title":["Clinicopathological analysis of composite lymphoma: A two-case report and literature review"],"prefix":"10.1515","volume":"15","author":[{"given":"Wei","family":"Gui","sequence":"first","affiliation":[{"name":"Department of Hematology, Shanxi Tumor Hospital , Taiyuan , Shanxi , People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanxi Tumor Hospital , Taiyuan , Shanxi 030013 , People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanxi Tumor Hospital , Taiyuan , Shanxi , People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanxi Tumor Hospital , Taiyuan , Shanxi , People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanxi Tumor Hospital , Taiyuan , Shanxi , People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"2022052423224795342_j_med-2020-0191_ref_001_w2aab3b7d517b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Raufi A, Jerkins J, Lyou Y, Jeyakumar DA. Patient with supraclavicular lymphadenopathy and anterior mediastinal mass presenting as a rare case of composite lymphoma: a case report and literature review. Case Rep Oncol. 2019;9:854\u201360.","DOI":"10.1159\/000453255"},{"key":"2022052423224795342_j_med-2020-0191_ref_002_w2aab3b7d517b1b6b1ab2b1b2Aa","unstructured":"Guan C, Li J, Xu P, Ouyang J, Chen B. Composite primary breast diffuse large B-cell lymphoma and T lymphoblastic leukemia\/lymphoma: report of a case and review of literature. Int J Clin Exp Pathol. 2015;8:9629\u201337."},{"key":"2022052423224795342_j_med-2020-0191_ref_003_w2aab3b7d517b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Demurtas A, Aliberti S, Bonello L, Di Celle PF, Cavaliere C, Barreca A, et al. Usefulness of multiparametric flow cytometry in detecting composite lymphoma: study of 17 cases in a 12-year period. Am J Clin Pathol. 2011;135:541\u201355.","DOI":"10.1309\/AJCPQKE25ADCFZWN"},{"key":"2022052423224795342_j_med-2020-0191_ref_004_w2aab3b7d517b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Suefuji N, Niino D, Arakawa F, Karube K, Kimura Y, Kiyasu J, et al. Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas. Pathol Int. 2012;62:690\u201398.","DOI":"10.1111\/j.1440-1827.2012.02858.x"},{"key":"2022052423224795342_j_med-2020-0191_ref_005_w2aab3b7d517b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Wang E, Papavassiliou P, Wang AR, Louissaint Jr A, Wang J, Hutchinson CB, et al. Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases. Hum Pathol. 2014;45:768\u201384.","DOI":"10.1016\/j.humpath.2013.11.008"},{"key":"2022052423224795342_j_med-2020-0191_ref_006_w2aab3b7d517b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Papalas JA, Puri PK, Sebastian S, Wang E. Primary cutaneous, composite, Epstein-Barr virus-associated, diffuse large B-cell lymphoma and peripheral T-cell lymphoma. Am J Dermato Pathol. 2011;33:719\u201325.","DOI":"10.1097\/DAD.0b013e3181fe363b"},{"key":"2022052423224795342_j_med-2020-0191_ref_007_w2aab3b7d517b1b6b1ab2b1b7Aa","unstructured":"Sugimoto KJ, Shimada A, Wakabayashi M, Imai H, Sekiguchi Y, Nakamura N, et al. A probable identical Epstein\u2013Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. Int J Clin Exp Pathol. 2013;7:411\u20137."},{"key":"2022052423224795342_j_med-2020-0191_ref_008_w2aab3b7d517b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Gasc\u00f3n Y, Mar\u00edn I, Menarguez J, Kwon M, Burdaspal A, Mart\u00ednez-Laperche C, et al. Composite lymphoma containing mantle cell and peripheral T-cell lymphoma, not otherwise specified: a report of 2 cases treated with up-front autologous stem cell transplantation. Appl Immunohistochem Mol Morphol. 2019;910:1097.","DOI":"10.1097\/01.HS9.0000565808.69164.21"},{"key":"2022052423224795342_j_med-2020-0191_ref_009_w2aab3b7d517b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Shi Y, Jia B, Xu W, Li W, Liu T, Liu P, et al. Chidamide in relapsed or refractory peripheral T cell lymphoma: a multicenter real-world study in China. J Hematol Oncol. 2017;10:69\u201374.","DOI":"10.1186\/s13045-017-0439-6"},{"key":"2022052423224795342_j_med-2020-0191_ref_010_w2aab3b7d517b1b6b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Jin J, Zheng C, Wu S. Therapeutic effect of chidamide on relapsed refractory angioimmunoblastic T-cell lymphoma: a case report and literature review. Medicine. 2018;97:2.","DOI":"10.1097\/MD.0000000000009611"}],"container-title":["Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/med\/15\/1\/article-p654.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2020-0191\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2020-0191\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T23:35:38Z","timestamp":1653435338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2020-0191\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,9,30]]},"published-print":{"date-parts":[[2020,9,30]]}},"alternative-id":["10.1515\/med-2020-0191"],"URL":"https:\/\/doi.org\/10.1515\/med-2020-0191","relation":{},"ISSN":["2391-5463"],"issn-type":[{"value":"2391-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}