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Amyloidosis can manifest as a systemic disease or a single-organ involvement (local form). Its etiology still remains unclear. Deposits of amyloid in the larynx are rare, accounting for between 0.2 and 1.2% of benign tumors of the larynx. In this retrospective study, we report the clinical aspects, diagnosis, treatment and follow-up of five female patients with localized laryngeal amyloidosis without systemic involvement. The patients were all treated successfully using microlaryngoscopy with CO<jats:sub>2<\/jats:sub> laser or cold instruments. Prognosis is excellent; however, appropriate follow-up is an important part of the long-term management of this disease in order to prevent and control the possibility of local recurrence.<\/jats:p>","DOI":"10.1515\/med-2020-0400","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T14:43:35Z","timestamp":1590504215000},"page":"327-332","source":"Crossref","is-referenced-by-count":14,"title":["Focus on localized laryngeal amyloidosis: management of five cases"],"prefix":"10.1515","volume":"15","author":[{"given":"Massimo","family":"Mesolella","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences , 80121 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Petruzzi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences , 80121 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Buono","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences , 80121 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Salerno","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences , 80121 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Antonio","family":"Salzano","sequence":"additional","affiliation":[{"name":"Department of Medicine , Surgery and Odontology , \u201cScuola Medica Salernitana\u201d University of Salerno , Salerno , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences , 80121 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Motta","sequence":"additional","affiliation":[{"name":"Department of Mental and Physical Health and Preventive Medicine , Head and Neck Surgery Unit , University of Campania \u201cLuigi Vanvitelli\u201d , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"2022052423242012698_j_med-2020-0400_ref_001_w2aab3b7d376b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Andree C, Sedivy R. 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