{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:18:35Z","timestamp":1785449915923,"version":"3.56.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Osteoarthritis (OA) is a common medical problem leading to chronic pain and physical\n               disability among the world\u2019s population. Analyzing the molecular background of\n               the degenerative arthritis creates the potential for developing novel targeted\n               methods of treatment. Fifty samples of meniscus, anterior cruciate ligaments (ACLs)\n               and articular surfaces were collected from patients who underwent total knee\n               arthroplasty in 2016. Enzyme-linked immunosorbent assay was used to assess the levels\n               of interleukin (IL)-1\u03b2, IL-6, tumor necrosis factor (TNF), transforming growth\n               factor-\u03b21 and LUMINEX for MMP-1, MMP-2, MMP-3, MMP-9 and MMP-13. The collected\n               data were correlated with the severity of radiological OA, demographic data and\n               clinical scales. Strong positive correlations in the concentration of\n               metalloproteinases and proinflammatory cytokines, TNF-\u03b1 (MMP-2 and MMP-13) and\n               IL-6 (MMP-13), were identified. MMP-13 had a positive correlation with the\n               concentration of MMP-1, MMP-2 and MMP-9. Negative correlation coefficient exists\n               between clinical conditions measured with the Western Ontario and McMaster\n               Universities Osteoarthritis Index scale and the level of TNF-\u03b1 and MMP-1. The\n               TNF-\u03b1 concentration was lower in the cartilage of the articular surface among\n               patients who took non-steroidal anti-inflammatory drugs periodically. The decrease in\n               MMP-2 in the cartilage of the articular surface corresponded with the severity of\n               radiological OA on the Kellgren\u2013Lawrence scale. Current treatment methods for\n               OA do not stop disease progression. Identifying signaling pathways and molecular\n               particles engaged in OA and their correlations with the patient\u2019s clinical\n               condition brings new therapeutic possibilities.<\/jats:p>","DOI":"10.1515\/med-2020-0402","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T12:00:31Z","timestamp":1588852831000},"page":"366-375","source":"Crossref","is-referenced-by-count":6,"title":["The complexity of molecular processes in osteoarthritis of the knee\n               joint"],"prefix":"10.1515","volume":"15","author":[{"given":"Pawe\u0142","family":"\u0141\u0119gosz","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology , 1st Faculty of Medicine , Medical University of Warsaw , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Sarzy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology , 1st Faculty of Medicine , Medical University of Warsaw , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Pulik","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology , 1st Faculty of Medicine , Medical University of Warsaw , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kotrych","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics , Traumatology and Orthopaedic Oncology , Pomeranian Medical University in Szczecin , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Ma\u0142dyk","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology , 1st Faculty of Medicine , Medical University of Warsaw , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"2022052423242006059_j_med-2020-0402_ref_001_w2aab3b7d388b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"He Q, Sun C, Lei W, Ma J. SOCS1 regulates apoptosis and inflammation by\n               inhibiting IL-4 signaling in IL-1beta-stimulated human osteoarthritic chondrocytes.\n               Biomed Res Int. 2017;2017:4601959.","DOI":"10.1155\/2017\/4601959"},{"key":"2022052423242006059_j_med-2020-0402_ref_002_w2aab3b7d388b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Litwic A, Edwards MH, Dennison EM, Cooper C. Epidemiology and burden of\n               osteoarthritis. Br Med Bull. 2013;105:185\u201399.","DOI":"10.1093\/bmb\/lds038"},{"key":"2022052423242006059_j_med-2020-0402_ref_003_w2aab3b7d388b1b6b1ab2b2b3Aa","unstructured":"Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull\n               World Health Organ. 2003;81(9):646\u201356."},{"key":"2022052423242006059_j_med-2020-0402_ref_004_w2aab3b7d388b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Henrotin Y, Pesesse L, Lambert C. Targeting the synovial angiogenesis as\n               a novel treatment approach to osteoarthritis. Ther Adv Musculoskelet Dis.\n               2014;6(1):20\u201334.","DOI":"10.1177\/1759720X13514669"},{"key":"2022052423242006059_j_med-2020-0402_ref_005_w2aab3b7d388b1b6b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a\n               disease of the joint as an organ. Arthritis Rheum.\n               2012;64(6):1697\u2013707.","DOI":"10.1002\/art.34453"},{"key":"2022052423242006059_j_med-2020-0402_ref_006_w2aab3b7d388b1b6b1ab2b2b6Aa","unstructured":"Clockaerts S. Role of infrapatellar fat pad in knee osteoarthritis lipid\n               lowering drugs as potential therapeutic strategy. Doctoral dissertation, Belgium:\n               Universiteit Antwerpen, 2013."},{"key":"2022052423242006059_j_med-2020-0402_ref_007_w2aab3b7d388b1b6b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Dieppe PA, Lohmander LS. Pathogenesis and management of pain in\n               osteoarthritis. Lancet. 2005;365(9463):965\u201373.","DOI":"10.1016\/S0140-6736(05)71086-2"},{"key":"2022052423242006059_j_med-2020-0402_ref_008_w2aab3b7d388b1b6b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Goldring MB, Goldring SR. Osteoarthritis. J Cell Physiol.\n               2007;213(3):626\u201334.","DOI":"10.1002\/jcp.21258"},{"key":"2022052423242006059_j_med-2020-0402_ref_009_w2aab3b7d388b1b6b1ab2b2b9Aa","doi-asserted-by":"crossref","unstructured":"Millward-Sadler SJ, Salter DM. Integrin-dependent signal cascades in\n               chondrocyte mechanotransduction. 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