{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:41:24Z","timestamp":1790145684165,"version":"4.0.1"},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pericentric inversion in chromosome 1 was thought to cause male infertility through\n               spermatogenic impairment, regardless of the breakpoint position. However, carriers of\n               pericentric inversion in chromosome 1 have been reported with normal fertility and\n               familial transmission. Here, we report two cases of pericentric inversion in\n               chromosome 1. One case was detected <jats:italic>in utero<\/jats:italic> via amniocentesis, and\n               the other case was detected after the wife of the carrier experienced two spontaneous\n               abortions within 5 years of marriage. Here, the effect of the breakpoint position of\n               the inversion in chromosome 1 on male infertility is examined and compared with the\n               published cases. The association between the breakpoint of pericentric inversion in\n               chromosome 1 and spermatogenesis is also discussed. Overall, the results suggest that\n               the breakpoint position deserves attention from physicians in genetic counseling as\n               inversion carriers can produce offspring.<\/jats:p>","DOI":"10.1515\/med-2020-0404","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T11:59:26Z","timestamp":1588852766000},"page":"343-348","source":"Crossref","is-referenced-by-count":10,"title":["Pericentric inversion in chromosome 1 and male\n               infertility"],"prefix":"10.1515","volume":"15","author":[{"given":"Ranwei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology, The Second Hospital of Jilin University , Changchun , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Hospital of Jilin University , Changchun , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Hospital of Jilin University , Changchun , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Hospital of Jilin University , Changchun , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Hospital of Jilin University , Changchun , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Hospital of Jilin University , Changchun , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"2022052423242010791_j_med-2020-0404_ref_001_w2aab3b7d398b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Ilacqua A, Izzo G, Emerenziani GP, et al. Lifestyle and fertility: the\n               influence of stress and quality of life on male fertility. Reprod Biol Endocrinol.\n               2018;16:115.","DOI":"10.1186\/s12958-018-0436-9"},{"key":"2022052423242010791_j_med-2020-0404_ref_002_w2aab3b7d398b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Barcel\u00f3 M, Mata A, Bassas L, et al. Exosomal microRNAs in seminal\n               plasma are markers of the origin of azoospermia and can predict the presence of sperm\n               in testicular tissue. Hum Reprod. 2018;33:1087\u201398.","DOI":"10.1093\/humrep\/dey072"},{"key":"2022052423242010791_j_med-2020-0404_ref_003_w2aab3b7d398b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Zhang H, Wang R, Yu Y, et al. Non-Robertsonian translocations involving\n               chromosomes 13, 14, or 15 in male infertility: 28 cases and a review of the\n               literature. 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Sperm-FISH analysis in\n               a pericentric inversion in chromosome 1, 46,XY,inv(1)(p22q42), associated with\n               infertility. Mol Hum Reprod. 2007;13:55\u20139.","DOI":"10.1093\/molehr\/gal094"},{"key":"2022052423242010791_j_med-2020-0404_ref_007_w2aab3b7d398b1b6b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Meschede D, Froster UG, Bergmann M, et al. Familial pericentric\n               inversion of chromosome 1 (p34q23) and male infertility with stage specific\n               spermatogenic arrest. J Med Genet. 1994;31:573\u20135.","DOI":"10.1136\/jmg.31.7.573"},{"key":"2022052423242010791_j_med-2020-0404_ref_008_w2aab3b7d398b1b6b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Rivera H, Alvarez-Arratia MC, Moller M, et al. Familial\n               inv(1)(p3500q21.3) associated with azoospermia. 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