{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:48:38Z","timestamp":1754398118531},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Ganglioneuroblastoma (GNB) is a neoplasm that arises from the primitive cells of the sympathetic nervous system during childhood. The current case is very unique because of the initial primary tumor manifestation in the orbit and an adrenal tumor being observed later during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>A 2-year-old girl presented to the Ophthalmology Department of our hospital complaining of swelling of the left upper eyelid for approximately one month. Orbital computed tomography (CT) revealed a left orbital mass with bone destruction. Thoracic and abdominal CT indicated no abnormalities. The mass was surgically resected, and histopathological analysis confirmed it as GNB. During follow-up, abdominal CT detected an adrenal tumor with internal calcification, a calcified nodule on the left side of the abdominal aorta, and mesenteric lymph nodes. Accordingly, primary orbital GNB and metastatic adrenal GNB were the possible considerations. We removed the adrenal tumor, and the patient underwent chemotherapy. However, the patient died 18 months after the ophthalmic surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Primary orbital GNB in children is easily misdiagnosed because of its rare occurrence and atypical clinical findings. Imaging methods combined with histopathological examination contribute to the detection and diagnosis of primary and metastatic GNBs. Thus, timely surgery combined with adjuvant chemotherapy and long-term follow-up is essential for controlling the metastasis of GNB and improving the survival rate of patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/med-2021-0230","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T20:46:03Z","timestamp":1626381963000},"page":"1076-1081","source":"Crossref","is-referenced-by-count":3,"title":["Primary orbital ganglioneuroblastoma: A case report"],"prefix":"10.1515","volume":"16","author":[{"given":"Ruixin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ophthalmic Laboratory, West China Hospital, Sichuan University , Chengdu 610041 , Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ophthalmic Laboratory, West China Hospital, Sichuan University , Chengdu 610041 , Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ophthalmic Laboratory, West China Hospital, Sichuan University , Chengdu 610041 , Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"2022091918191462001_j_med-2021-0230_ref_001","doi-asserted-by":"crossref","unstructured":"Youlden DR, Jones BC, Cundy TP, Karpelowsky J, Aitken JF, McBride CA. 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