{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:02:45Z","timestamp":1785798165631,"version":"3.56.0"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    As a gaseous mediator, hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) has many physiological effects and pathological effects in atherosclerosis. In recent years, many exogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S donors have been synthesized to study atherosclerosis diseases. In this study, proglumide-(5-(4-hydroxyphenyl)-3\n                    <jats:italic>H<\/jats:italic>\n                    -1,2-dithiole-3-thione) (P-A) was synthesized as a H\n                    <jats:sub>2<\/jats:sub>\n                    S donor. The protective effect and mechanism of P-A on HUVEC that was injured by ox-LDL were detected. The HUEVCs were affected by 100\u2009\u03bcmol\/L P-A for 24\u2009h; the release of H\n                    <jats:sub>2<\/jats:sub>\n                    S was the largest. After 100\u2009\u03bcmol\/L P-A acted on HUVEC damage model for 12\u2009h, the cell proliferation activity was the best. The results showed that P-A can downregulate the expression of p-NF-\u043aBp65 protein and reduce the amount of TNF-\u03b1 and IL-6 and promote the formation of IL-10 by inhibiting the NF-\u043aB pathway, and also induce the expression of superoxide dismutase (SOD) to protect HUVEC from ox-LDL injury. P-A can also regulate JAK\/STAT pathway to reduce the expression of p-JAK2 protein and reduce the production of IL-6 and TNF-\u03b1. P-A has protective effect on HUVEC injured by ox-LDL, and the protective mechanism is related to the regulation of JAK\/STAT pathway and NF-\u043aB pathway.\n                  <\/jats:p>","DOI":"10.1515\/med-2021-0287","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T16:35:25Z","timestamp":1631205325000},"page":"1318-1327","source":"Crossref","is-referenced-by-count":7,"title":["Novel H\n                    <sub>2<\/sub>\n                    S donor proglumide-ADT-OH protects HUVECs from ox-LDL-induced injury through NF-\u03baB and JAK\/SATA pathway"],"prefix":"10.1515","volume":"16","author":[{"given":"Xuelan","family":"Ou","sequence":"first","affiliation":[{"name":"Institute of Materia Medica, School of Pharmacy, North Sichuan Medical College , Nanchong 637100 , Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqin","family":"Xia","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, School of Pharmacy, North Sichuan Medical College , Nanchong 637100 , Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, School of Pharmacy, North Sichuan Medical College , Nanchong 637100 , Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, School of Pharmacy, North Sichuan Medical College , Nanchong 637100 , Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, School of Pharmacy, North Sichuan Medical College , Nanchong 637100 , Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, School of Pharmacy, North Sichuan Medical College , Nanchong 637100 , Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, School of Pharmacy, North Sichuan Medical College , Nanchong 637100 , Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, School of Pharmacy, North Sichuan Medical College , Nanchong 637100 , Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"2022091918195042681_j_med-2021-0287_ref_001","doi-asserted-by":"crossref","unstructured":"Taleb S\n. 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