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It is believed that excessive cortisol secretion due to psychosocial stress-induced hypothalamic-pituitary-adrenal axis activation might be involved in the pathogenesis of MetS. We sought to explore the association between MetS and psychosocial risk factors, as well as cortisol concentration measured in different biological specimens including saliva, blood serum, and hair samples. The study was conducted on a sample of 163 young and middle-aged men who were divided into groups according to the presence of MetS. Hair cortisol concentration (HCC) was determined using high performance liquid chromatography with UV detection, while blood serum and salivary cortisol levels were measured by enzyme-linked immunoassay. Lipid metabolism biomarkers were determined using routine laboratory methods. Anthropometric and lifestyle characteristics, as well as self-reported psychosocial indicators, were also examined. Significantly higher HCC and lower social support level among participants with MetS compared with individuals without MetS were found. However, no significant differences in blood serum and salivary cortisol levels were observed between men with and without MetS. In conclusion, chronically elevated cortisol concentration might be a potential contributing factor to the development of MetS.<\/jats:p>","DOI":"10.1515\/med-2021-0298","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T20:13:00Z","timestamp":1623874380000},"page":"873-881","source":"Crossref","is-referenced-by-count":14,"title":["Association between hair cortisol concentration and metabolic syndrome"],"prefix":"10.1515","volume":"16","author":[{"given":"Egl\u0117","family":"Mazgelyt\u0117","sequence":"first","affiliation":[{"name":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asta","family":"Ma\u017eeikien\u0117","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neringa","family":"Burokien\u0117","sequence":"additional","affiliation":[{"name":"Clinics of Internal Diseases, Family Medicine and Oncology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0117da","family":"Matuzevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Au\u0161ra","family":"Linkevi\u010di\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita Au\u0161rel\u0117","family":"Ku\u010dinskien\u0117","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dovil\u0117","family":"Kar\u010diauskait\u0117","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"2022091918210276407_j_med-2021-0298_ref_001","doi-asserted-by":"crossref","unstructured":"Wang HH, Lee DK, Liu M, Portincasa P, Wang DQH. 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