{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:48:23Z","timestamp":1790880503537,"version":"4.1.0"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to integrate the serum exosomal miRNA miR-122-5p with canonical serological biomarkers for the non-invasive screening of chronic atrophic gastritis (CAG) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>miR-122-5p and U6 were amplified by the quantitative reverse transcription polymerase chain reaction (RT-qPCR), gastrin (GAS), pepsinogen I (PG-I), and PG-II and were measured by ELISA. The area under the receiver operating characteristic (ROC) curves and their correlation were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the present study, GAS level and PG-I\/PG-II ratio (PGR) were increased in CAG group, but there was no significant difference in PG-I or PG-II levels between CAG group and chronic non-atrophic gastritis (CNAG) group. Only GAS level and PG-I\/PG-II ratio were significantly correlated with atrophy, and not any other clinicopathologic factors. Expression of hsa-miR-122-5p positively correlated with GAS level, PG-I level, and PGR, while it negatively correlated with PG-II level; however, none of them had significant difference. The combination of GAS, PGR, and hsa-miR-122-5p presented as a better model for non-invasive screening of CAG compared to others.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggested that serum exosomal hsa-miR-122-5p combined with GAS and PGR would elevate accuracy and specificity in non-invasive screening of CAG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2021-0342","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T16:38:45Z","timestamp":1631205525000},"page":"1350-1355","source":"Crossref","is-referenced-by-count":5,"title":["Serum exosomal miR-122-5p, GAS, and PGR in the non-invasive diagnosis of CAG"],"prefix":"10.1515","volume":"16","author":[{"given":"Naihua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University , Guangzhou 510080 , Guangdong , People\u2019s Republic of China"},{"name":"Department of Oncology, Scientific Research Center, The First Affiliated Hospital of Guangdong Pharmaceutical University , Guangzhou 510080 , Guangdong , People\u2019s Republic of China"},{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province , Guangzhou 510080 , Guangdong , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuancheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chinese Internal Medicine, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine , Guangzhou 510405 , Guangdong Province , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengbin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chinese Internal Medicine, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine , No. 12 Jichang Road , Guangzhou 510405 , Guangdong Province , People\u2019s Republic of China"},{"name":"Department of Spleen Disease and Gastropathy, The First Affiliated Hospital of Guangzhou University of Chinese Medicine , No. 16 Jichang Road , Guangzhou 510405 , Guangdong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University , Gonghexiheng Street 1 , Guangzhou 510080 , Guangdong , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"2022091918210230625_j_med-2021-0342_ref_001","doi-asserted-by":"crossref","unstructured":"Weck MN\n, \nBrenner H\n. 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