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The quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the expression of MALAT1 in MPM cell lines. The effects of MALAT1 and miR-141-3p on the proliferation, migration, and invasion of MPM cells were studied through a series of <jats:italic>in vitro<\/jats:italic> cellular experiments. The flow cytometry was utilized to detect the cell apoptosis. The dual\u2010luciferase reporter assay was employed to explore the binding relationship among MALAT1, miR-141-3p, and YES-associated protein 1 (YAP1). MALAT1 was overexpressed in MPM cell lines, while its knockdown significantly inhibited the cell proliferation, migration, and invasion, and increased the number of MPM cells in the G0\/G1 phase. In addition, MALAT1 could directly bind to miR-141-3p and inhibit its expression. YAP1 has been identified as a downstream target of miR-141-3p, and its expression level was inhibited by miR-141-3p. MALAT1 can be used as a competitive endogenous RNA (ceRNA) to regulate the YAP1-Hippo signaling pathway through miR-141-3p, promote the proliferation, migration, and invasion of MPM cells, and provide a new target for the therapy of MPM.<\/jats:p>","DOI":"10.1515\/med-2021-0383","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T22:25:04Z","timestamp":1635978304000},"page":"1653-1667","source":"Crossref","is-referenced-by-count":12,"title":["MALAT1 promotes malignant pleural mesothelioma by sponging miR-141-3p"],"prefix":"10.1515","volume":"16","author":[{"given":"Pei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University , Kunming 650032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiwei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University , Kunming 650032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University , Kunming 650032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Luoyang CITIC Central Hospital , Luoyang 471003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University , Kunming 650032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University , No. 295 Xichang Road , Kunming 650032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"2022091918210254232_j_med-2021-0383_ref_001","doi-asserted-by":"crossref","unstructured":"Carbone M, Adusumilli PS, Alexander HR Jr, Baas P, Bardelli F, Bononi A, et al. 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