{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:21:41Z","timestamp":1771464101768,"version":"3.50.1"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acute lung injury (ALI) is a respiratory disorder characterized by acute respiratory failure. circRNA mus musculus (mmu)-circ_0001679 was reported overexpressed in septic mouse models of ALI. Here the function of circ_0001679 in sepsis-induced ALI was investigated. <jats:italic>In vitro<\/jats:italic> models and animal models with ALI were, respectively, established in mouse lung epithelial (MLE)-12 cells and C57BL\/6 mice. Pulmonary specimens were harvested for examination of the pathological changes. The pulmonary permeability was examined by wet-dry weight (W\/D) ratio and lung permeability index. The levels of tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-6, and IL-1\u03b2 in the bronchoalveolar lavage fluid (BALF), the lung tissues, and the supernatant of MLE-12 cells were measured by enzyme linked immunosorbent assay . Apoptosis was determined by flow cytometry. Bioinformatics analysis and luciferase reporter assay were used to assess the interactions between genes. We found that circ_0001679 was overexpressed in lipopolysaccharide (LPS)-stimulated MLE-12 cells. circ_0001679 knockdown suppressed apoptosis and proinflammatory cytokine production induced by LPS. Moreover, circ_0001679 bound to mmu-miR-338-3p and miR-338-3p targeted dual-specificity phosphatases 16 (DUSP16). DUSP16 overexpression reversed the effect of circ_0001679 knockdown in LPS-stimulated MLE-12 cells. Furthermore, circ_0001679 knockdown attenuated lung pathological changes, reduced pulmonary microvascular permeability, and suppressed inflammation in ALI mice. Overall, circ_0001679 knockdown inhibits sepsis-induced ALI progression through the miR-338-3p\/DUSP16 axis.<\/jats:p>","DOI":"10.1515\/med-2022-0417","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T07:58:18Z","timestamp":1646121498000},"page":"403-413","source":"Crossref","is-referenced-by-count":19,"title":["circRNA_0001679\/miR-338-3p\/DUSP16 axis aggravates acute lung injury"],"prefix":"10.1515","volume":"17","author":[{"given":"Jiang","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Respiratory, The Second People\u2019s Hospital of Lianyungang , Lianyungang 222023 , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukuan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Second People\u2019s Hospital of Lianyungang , Lianyungang 222023 , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Futao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Second People\u2019s Hospital of Lianyungang , Lianyungang 222023 , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Second People\u2019s Hospital of Lianyungang , Lianyungang 222023 , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Second People\u2019s Hospital of Lianyungang , Lianyungang 222023 , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifeng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Second People\u2019s Hospital of Lianyungang , Lianyungang 222023 , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Second People\u2019s Hospital of Lianyungang , Lianyungang 222023 , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaohong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine , Zhongfu Road 1, Gulou District , Nanjing 210003 , Jiangsu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"2024010515405376227_j_med-2022-0417_ref_001","unstructured":"Lee J, Levy MM. 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