{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:21:58Z","timestamp":1768818118393,"version":"3.49.0"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although cell-based or animal-based research evidence support the association of Holliday junction recognition protein (HJURP) with cancers, no pan-cancer investigation has been reported. The datasets of Gene Expression Omnibus database along with The Cancer Genome Atlas project were used to evaluate the expression of HJURP in various types of tumors. HJURP is overexpressed in a considerable number of cancers, and some changes in DNA methylation and genetic alterations are discovered in some types of tumors, such as kidney-related and adrenal gland-related tumors. Based on PrognoScan and gene expression profiling interactive analysis (GEPIA), the elevated expression of HJURP worsened the survival time of individuals with cancer. The biological general repository for interaction datasets (BioGRID) and The database for annotation, visualization and integrated discovery (DAVID) were used to establish the functional molecular network. It revealed that the cell cycle and p53 signaling pathway are the key molecular mechanisms that HJURP promotes carcinogenesis. The nomograms between HJURP and clinical pathological factors based on the Cox proportional hazards model showed a good prognostic performance in kidney carcinoma, hepatocellular carcinoma, and lung adenocarcinoma. Our first pan-cancer study provides a relatively profound insights into the oncogenic roles of HJURP across different tumors.<\/jats:p>","DOI":"10.1515\/med-2022-0423","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T05:40:06Z","timestamp":1645162806000},"page":"317-328","source":"Crossref","is-referenced-by-count":6,"title":["A pan-cancer analysis of the oncogenic role of Holliday junction recognition protein in human tumors"],"prefix":"10.1515","volume":"17","author":[{"given":"Rong","family":"Su","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310003 , China"},{"name":"NHC Key Laboratory of Combined Multi-organ Transplantation , Hangzhou 310003 , China"},{"name":"Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences , Hangzhou 310003 , China"},{"name":"Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Zhejiang Province , Hangzhou 310003 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hechen","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310003 , China"},{"name":"NHC Key Laboratory of Combined Multi-organ Transplantation , Hangzhou 310003 , China"},{"name":"Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences , Hangzhou 310003 , China"},{"name":"Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Zhejiang Province , Hangzhou 310003 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingxing","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310003 , China"},{"name":"NHC Key Laboratory of Combined Multi-organ Transplantation , Hangzhou 310003 , China"},{"name":"Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences , Hangzhou 310003 , China"},{"name":"Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Zhejiang Province , Hangzhou 310003 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310003 , China"},{"name":"NHC Key Laboratory of Combined Multi-organ Transplantation , Hangzhou 310003 , China"},{"name":"Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences , Hangzhou 310003 , China"},{"name":"Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Zhejiang Province , Hangzhou 310003 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyong","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310003 , China"},{"name":"NHC Key Laboratory of Combined Multi-organ Transplantation , Hangzhou 310003 , China"},{"name":"Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences , Hangzhou 310003 , China"},{"name":"Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Zhejiang Province , Hangzhou 310003 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310003 , China"},{"name":"NHC Key Laboratory of Combined Multi-organ Transplantation , Hangzhou 310003 , China"},{"name":"Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences , Hangzhou 310003 , China"},{"name":"Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Zhejiang Province , Hangzhou 310003 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310003 , China"},{"name":"NHC Key Laboratory of Combined Multi-organ Transplantation , Hangzhou 310003 , China"},{"name":"Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences , Hangzhou 310003 , China"},{"name":"Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Zhejiang Province , Hangzhou 310003 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine , #79 Qingchun Road , Hangzhou 310003 , China"},{"name":"NHC Key Laboratory of Combined Multi-organ Transplantation , Hangzhou 310003 , China"},{"name":"Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences , Hangzhou 310003 , China"},{"name":"Key Laboratory of Organ Transplantation, Research Center 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