{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:51:32Z","timestamp":1792518692593,"version":"4.5.0"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pulmonary <jats:italic>Aspergillus<\/jats:italic> infection may have a variety of manifestations depending on the patients\u2019 immunity status and pre-existing lung conditions. Radiographically, aspergilloma, which is usually associated with noninvasive <jats:italic>Aspergillus fumigatus<\/jats:italic> conidia, may feature a characteristic mass in a cavity commonly located in the upper lobes of the lung. It is typically encountered upon pre-existing lung damage. Here we report <jats:italic>Aspergillus<\/jats:italic> growing in a pulmonary metastatic cavity in a 47-year-old male worker with a history of tongue cancer after a radical operation with neck dissection and concurrent chemotherapy in 2014. Chest radiography and computed tomography showed a cavitary lesion with a ball-in-hole lesion in the right upper lobe (RUL) and two cystic lesions within the bilateral upper lung field. Endobronchial ultrasound-guided transbronchial biopsy (EBUS-TBB) from the RUL anterior segmental bronchus (RB3) revealed the presence of <jats:italic>Aspergillus<\/jats:italic> conidia and squamous cell carcinoma. Wedge resection of the cystic lesion within the left upper lobe confirmed the diagnosis of metastatic squamous cell carcinoma. This is a rare case of aspergillosis within cavities of pulmonary metastases in a patient who was diagnosed with tongue squamous cell carcinoma. The conclusive distinction between neoplasm and fungal infection is difficult to achieve by radiography, and a pathological biopsy by EBUS-TBB is necessary to aid diagnosis. Clinicians should be aware of such an atypical presentation of metastases coexisting with <jats:italic>Aspergillus<\/jats:italic> infection.<\/jats:p>","DOI":"10.1515\/med-2022-0527","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T13:25:03Z","timestamp":1658323503000},"page":"1325-1329","source":"Crossref","is-referenced-by-count":3,"title":["Concurrent aspergillosis and cystic pulmonary metastases in a patient with tongue squamous cell carcinoma"],"prefix":"10.1515","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-0809","authenticated-orcid":false,"given":"Hung-Chieh","family":"Su","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, China Medical University Hospital , Taichung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Chi","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pathology, China Medical University Hospital , Taichung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Lung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, China Medical University Hospital , Taichung , Taiwan"},{"name":"Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital , Taichung City 40402 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Chih","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, China Medical University Hospital , Taichung , Taiwan"},{"name":"Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital , Taichung City 40402 , Taiwan"},{"name":"Department of Internal Medicine, Hyperbaric Oxygen Therapy Center, China Medical University Hospital , Taichung , Taiwan"},{"name":"School of Medicine, China Medical University , Taichung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, China Medical University Hospital , Taichung , Taiwan"},{"name":"Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital , No. 2, Yude Road, North District Taichung City 40402 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"2022120618373760343_j_med-2022-0527_ref_001","doi-asserted-by":"crossref","unstructured":"Dzopali\u0107 T, Bo\u017ei\u0107-Nedeljkovi\u0107 B, Juri\u0161i\u0107 V. 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