{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T06:01:20Z","timestamp":1670392880295},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The objective of this study was to assess the impact of marital status on tonsil squamous cell carcinomas (TSCCs) prognosis and to analyze whether the impact is correlated with gender, age, and race. We examined the clinicopathological variables using Chi-squared tests and evaluated the association between survival and different variables using the methods of Kaplan\u2013Meier. Univariate and multivariate analyses were performed to determine the effects of each variable on survival. A total of 10,720 patients were analyzed. The rate of being married was higher among Asian or Caucasian, and this rate decreased with higher tumor stage. While both married male and female survivors benefit from their marital status, we found a differential in cancer-specific survival based on gender, with males benefitting more than females (<jats:italic>p<\/jats:italic> &lt; 0.05). The same results were found in overall survival. Subgroup analysis shows that the protective effect of marriage was consistent in all patients except for N3 groups (all, <jats:italic>p<\/jats:italic> &lt; 0.05). While there are survival benefits for married patients with TSCCs, married\/partnered males may benefit more than females. Age, race, and gender could affect the correlation between marital status and survival.<\/jats:p>","DOI":"10.1515\/med-2022-0568","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T22:00:20Z","timestamp":1668204020000},"page":"1773-1779","source":"Crossref","is-referenced-by-count":0,"title":["Marital status and its correlation with age, race, and gender in prognosis of tonsil squamous cell carcinomas"],"prefix":"10.1515","volume":"17","author":[{"given":"Yujiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Fudan University Shanghai Cancer Center , Shanghai 200032 , China"},{"name":"Department of Oncology, Shanghai Medical College , Shanghai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaosu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Fudan University Shanghai Cancer Center , 270 Dong An Road , Shanghai 200032 , China"},{"name":"Department of Oncology, Shanghai Medical College , Shanghai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"2022120618374251413_j_med-2022-0568_ref_001","doi-asserted-by":"crossref","unstructured":"Ryerson AB, Peters ES, Coughlin SS, Chen VW, Gillison ML, Reichman ME, et al. Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998\u20132003. Cancer\u2009\u2013\u2009Am Cancer Soc. 2008;113(10 Suppl):2901\u20139.","DOI":"10.1002\/cncr.23745"},{"key":"2022120618374251413_j_med-2022-0568_ref_002","doi-asserted-by":"crossref","unstructured":"Schantz SP, Yu GP. Head and neck cancer incidence trends in young Americans, 1973\u20131997, with a special analysis for tongue cancer. Arch Otolaryngol Head Neck Surg. 2002;128(3):268\u201374.","DOI":"10.1001\/archotol.128.3.268"},{"key":"2022120618374251413_j_med-2022-0568_ref_003","doi-asserted-by":"crossref","unstructured":"Shiboski CH, Schmidt BL, Jordan RCK. Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20\u201344 years. Cancer\u2009\u2013\u2009Am Cancer Soc. 2005;103(9):1843\u20139.","DOI":"10.1002\/cncr.20998"},{"key":"2022120618374251413_j_med-2022-0568_ref_004","doi-asserted-by":"crossref","unstructured":"Osazuwa-Peters N, Adjei BE, Chen BY, Tobo BB, Varvares MA. Association between head and neck squamous cell carcinoma survival, smoking at diagnosis, and marital status. JAMA Otolaryngol Head Neck Surg. 2018;144(1):43\u201350.","DOI":"10.1001\/jamaoto.2017.1880"},{"key":"2022120618374251413_j_med-2022-0568_ref_005","doi-asserted-by":"crossref","unstructured":"Schaefer EW, Wilson MZ, Goldenberg D, Mackley H, Koch W, Hollenbeak CS. Effect of marriage on outcomes for elderly patients with head and neck cancer. Head Neck. 2015;37(5):735\u201342.","DOI":"10.1002\/hed.23657"},{"key":"2022120618374251413_j_med-2022-0568_ref_006","doi-asserted-by":"crossref","unstructured":"Inverso G, Mahal BA, Aizer AA, Donoff RB, Chau NG, Haddad RI. Marital status and head and neck cancer outcomes. Cancer\u2009\u2013\u2009Am Cancer Soc. 2015;121(8):1273\u20138.","DOI":"10.1002\/cncr.29171"},{"key":"2022120618374251413_j_med-2022-0568_ref_007","doi-asserted-by":"crossref","unstructured":"Aizer AA, Chen MH, McCarthy EP, Mendu ML, Koo S, Wilhite TJ, et al. Marital status and survival in patients with cancer. J Clin Oncol. 2013;31(31):3869\u201376.","DOI":"10.1200\/JCO.2013.49.6489"},{"key":"2022120618374251413_j_med-2022-0568_ref_008","doi-asserted-by":"crossref","unstructured":"Goodwin JS, Hunt WC, Key CR, Samet JM. The effect of marital status on stage, treatment, and survival of cancer patients. JAMA. 1987;258(21):3125\u201330.","DOI":"10.1001\/jama.258.21.3125"},{"key":"2022120618374251413_j_med-2022-0568_ref_009","doi-asserted-by":"crossref","unstructured":"Howren MB, Christensen AJ, Hynds KL, Van Liew JR, Funk GF. Influence of pretreatment social support on health-related quality of life in head and neck cancer survivors: results from a prospective study. Head Neck. 2013;35(6):779\u201387.","DOI":"10.1002\/hed.23029"},{"key":"2022120618374251413_j_med-2022-0568_ref_010","doi-asserted-by":"crossref","unstructured":"Osazuwa Peters N, Christopher KM, Cass LM, Massa ST, Hussaini AS, Behera A, et al. What\u2019s love got to do with it? Marital status and survival of head and neck cancer. Eur J Cancer Care. 2019;28(4):e13022.","DOI":"10.1111\/ecc.13022"},{"key":"2022120618374251413_j_med-2022-0568_ref_011","doi-asserted-by":"crossref","unstructured":"Liao P, Lee C. The influence of marital status on survival for patients aged 65 years and younger with oral cavity cancer. Auris Nasus Larynx. 2018;45(6):1227\u201332.","DOI":"10.1016\/j.anl.2018.03.007"},{"key":"2022120618374251413_j_med-2022-0568_ref_012","doi-asserted-by":"crossref","unstructured":"Xu C, Chen YP, Liu X, Tang LL, Chen L, Mao YP, et al. Socioeconomic factors and survival in patients with non\u2010metastatic head and neck squamous cell carcinoma. 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