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The rat liver cirrhosis model was established through the administration of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) for 8 weeks. Hematoxylin\u2013eosin staining was performed to unveil the intestinal injury induced by liver cirrhosis. Enzyme-linked immunosorbent and reverse transcription PCR (RT-PCR) analysis were used to determine the levels of 25(OH)-VD, vitamin D receptor, Cytochrome P450 24A1 (CYP24A1), and \u03b1-defensin 5 (DEFA5) in rat and human serum of liver cirrhosis. Furthermore, liver cirrhosis rats were treated with low-dose (500\u2009IU\/kg) and high-dose (2,000\u2009IU\/kg) vitamin D intraperitoneally. The expression levels of TLR4\/MyD88\/NF-\u03baB signaling pathway were evaluated by RT-PCR and Western blot. In conclusion, we determined the deficiency of vitamin D and down-regulation of DEFA5 and intestinal damage induced by liver cirrhosis. Moreover, vitamin D effectively inhibited liver cirrhosis-induced intestinal inflammation and oxidative stress through the TLR4\/MyD88\/NF-\u03baB pathway. Vitamin D might be a promising therapeutic strategy for future treatment of liver-induced intestinal injury.<\/jats:p>","DOI":"10.1515\/med-2023-0714","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:10:54Z","timestamp":1685358654000},"source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4\/MyD88\/NF-\u03baB signaling pathway"],"prefix":"10.1515","volume":"18","author":[{"given":"Mei","family":"Luo","sequence":"first","affiliation":[{"name":"Infectious Disease Laboratory, Chengdu Public Health Clinical Center , Chengdu , 610061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Chengdu Public Health Clinical Center , Chengdu , 610061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jike","family":"Li","sequence":"additional","affiliation":[{"name":"Infectious Disease Laboratory, Chengdu Public Health Clinical Center , Chengdu , 610061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxia","family":"Luo","sequence":"additional","affiliation":[{"name":"Infectious Disease Laboratory, Chengdu Public Health Clinical Center , Chengdu , 610061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hepatology Clinic, Chengdu Public Health Clinical Center , Chengdu , 610061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxi","family":"Wu","sequence":"additional","affiliation":[{"name":"Infectious Disease Laboratory, Chengdu Public Health Clinical Center , Chengdu , 610061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Chengdu Public Health Clinical Center , Chengdu , 610061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Wu","sequence":"additional","affiliation":[{"name":"Infectious Disease Laboratory, Chengdu Public Health Clinical Center , Chengdu , 610061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"2023083109475891412_j_med-2023-0714_ref_001","doi-asserted-by":"crossref","unstructured":"Yeom SK, Lee CH, Cha SH, Park CM. 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