{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:39:35Z","timestamp":1788194375695,"version":"build-2803163510"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The aim of this study was to evaluate the effect of maternal age and body mass index (BMI) on induction of labor with oral misoprostol for premature rupture of membrane (PROM) at term. We have conducted retrospective cross-sectional study, including only term (37 weeks or more of gestation) PROM in healthy nulliparous women with a negative vaginal-rectal swab for group B streptococcus, a single cephalic fetus with normal birthweight, and uneventful pregnancy that were induced after 24\u2009h from PROM. Ninety-one patients were included. According to the multivariate logistic regression, age and BMI odds ratio (OR) for induction success were 0.795 and 0.857, respectively. The study population was divided into two groups based on age (&lt;35 and \u226535 years) and obesity (BMI &lt;30 and \u226530). Older women reported a higher induction failure rate (<jats:italic>p<\/jats:italic> &lt; 0.001); longer time to cervical dilation of 6\u2009cm (<jats:italic>p<\/jats:italic> = 0.03) and delivery (<jats:italic>p<\/jats:italic> &lt; 0.001). Obese women reported a higher induction failure rate (<jats:italic>p<\/jats:italic> = 0.01); number of misoprostol doses (<jats:italic>p<\/jats:italic> = 0.03), longer time of induction (<jats:italic>p<\/jats:italic> = 0.03) to cervical dilatation of 6\u2009cm (<jats:italic>p<\/jats:italic> &lt; 0.001), and delivery (<jats:italic>p<\/jats:italic> &lt; 0.001); and higher cesarean section (<jats:italic>p<\/jats:italic> = 0.012) and episiotomy rate (<jats:italic>p<\/jats:italic> = 0.007). In conclusion, maternal age and BMI are two of the main factors that influence oral misoprostol efficacy and affect the failure of induction rate in term PROM.<\/jats:p>","DOI":"10.1515\/med-2023-0747","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T14:16:13Z","timestamp":1688480173000},"source":"Crossref","is-referenced-by-count":9,"title":["Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study"],"prefix":"10.1515","volume":"18","author":[{"given":"Gianfranco","family":"Sfregola","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cDimiccoli\u201d Hospital , 76121 Barletta , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Sfregola","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cDimiccoli\u201d Hospital , 76121 Barletta , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Ruta","sequence":"additional","affiliation":[{"name":"Health Agency BAT, General Direction , 76123 Andria , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Zendoli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital of Bisceglie , 76011 Bisceglie , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Musicco","sequence":"additional","affiliation":[{"name":"School of Nursing Sciences, University of Foggia , 71122 Foggia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Garzon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AOUI Verona, University of Verona , 37129 Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Uccella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AOUI Verona, University of Verona , 37129 Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Etrusco","sequence":"additional","affiliation":[{"name":"Unit of Gynecologic Oncology, ARNAS \u201cCivico \u2013 Di Cristina \u2013 Benfratelli\u201d, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo , 90133 Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Chiantera","sequence":"additional","affiliation":[{"name":"Unit of Gynecologic Oncology, ARNAS \u201cCivico \u2013 Di Cristina \u2013 Benfratelli\u201d, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo , 90133 Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Terzic","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Nazarbayev University , 010000 Astana , Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Gynecological, Obstetrical and Urological Sciences, Sapienza University of Rome , 00185 Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"additional","affiliation":[{"name":"Unit of Gynecologic Oncology, ARNAS \u201cCivico \u2013 Di Cristina \u2013 Benfratelli\u201d, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo , 90133 Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"2023083109481188228_j_med-2023-0747_ref_001","doi-asserted-by":"crossref","unstructured":"Duff P. 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