{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:09:36Z","timestamp":1790662176613,"version":"4.1.0"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Phosphodiesterase 4D interacting protein (<jats:italic>PDE4DIP<\/jats:italic>) interacts with cAMP-specific phosphodiesterase 4D and its abnormal expression promotes the development of hematological malignancies, breast cancer, and pineal cell carcinoma. However, there is currently no systematic pan-cancer analysis of the association between <jats:italic>PDE4DIP<\/jats:italic> and various cancers. Thus, this study aimed to elucidate the potential functions of <jats:italic>PDE4DIP<\/jats:italic> in various cancers. Based on the multiple public databases and online websites, we conducted comprehensive analyses for <jats:italic>PDE4DIP<\/jats:italic> in various cancers, including differential expression, prognosis, genetic variation, DNA methylation, and immunity. We thoroughly analyzed the specific role of <jats:italic>PDE4DIP<\/jats:italic> in acute myeloid leukemia (LAML). The results indicated that there were differences in <jats:italic>PDE4DIP<\/jats:italic> expression in cancers, and in kidney chromophobe, LAML, pheochromocytoma and paraganglioma, thymoma, and uveal melanoma, <jats:italic>PDE4DIP<\/jats:italic> had potential prognostic value. <jats:italic>PDE4DIP<\/jats:italic> expression was also correlated with genetic variation, DNA methylation, immune cell infiltration, and immune-related genes in cancers. Functional enrichment analysis showed that <jats:italic>PDE4DIP<\/jats:italic> was mainly related to immune-related pathways in cancers, and in LAML, <jats:italic>PDE4DIP<\/jats:italic> was mainly related to immunoglobulin complexes, T-cell receptor complexes, and immune response regulatory signaling pathways. Our study systematically revealed for the first time the potential prognostic and immunotherapeutic value of <jats:italic>PDE4DIP<\/jats:italic> in various cancers, including LAML.<\/jats:p>","DOI":"10.1515\/med-2023-0782","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T09:11:26Z","timestamp":1693473086000},"source":"Crossref","is-referenced-by-count":7,"title":["Pan-cancer analysis of the <i>PDE4DIP<\/i> gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia"],"prefix":"10.1515","volume":"18","author":[{"given":"Qi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion, The First People\u2019s Hospital of Yunnan Province \u2013 The Affiliated Hospital of Kunming University of Science and Technology , 650032 Kunming , Yunnan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The First People\u2019s Hospital of Yunnan Province \u2013 The Affiliated Hospital of Kunming University of Science and Technology , 650032 Kunming , Yunnan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The First People\u2019s Hospital of Yunnan Province \u2013 The Affiliated Hospital of Kunming University of Science and Technology , 650032 Kunming , Yunnan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The First People\u2019s Hospital of Yunnan Province \u2013 The Affiliated Hospital of Kunming University of Science and Technology , 650032 Kunming , Yunnan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The First People\u2019s Hospital of Yunnan Province \u2013 The Affiliated Hospital of Kunming University of Science and Technology , 650032 Kunming , Yunnan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The First People\u2019s Hospital of Yunnan Province \u2013 The Affiliated Hospital of Kunming University of Science and Technology , 650032 Kunming , Yunnan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"2023083109481205742_j_med-2023-0782_ref_001","doi-asserted-by":"crossref","unstructured":"Hsien Lai S, Zervoudakis G, Chou J, Gurney ME, Quesnelle KM. PDE4 subtypes in cancer. Oncogene. 2020;39(19):3791\u2013802. 10.1038\/s41388-020-1258-8.","DOI":"10.1038\/s41388-020-1258-8"},{"key":"2023083109481205742_j_med-2023-0782_ref_002","doi-asserted-by":"crossref","unstructured":"Pullamsetti SS, Banat GA, Schmall A, Szibor M, Pomagruk D, Hanze J, et al. Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF. Oncogene. 2013;32(9):1121\u201334. 10.1038\/onc.2012.136.","DOI":"10.1038\/onc.2012.136"},{"key":"2023083109481205742_j_med-2023-0782_ref_003","doi-asserted-by":"crossref","unstructured":"Rahrmann EP, Collier LS, Knutson TP, Doyal ME, Kuslak SL, Green LE, et al. Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen. 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