{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:42:42Z","timestamp":1790347362086,"version":"4.1.0"},"reference-count":41,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We aimed to investigate the clinical efficacy of blood purification technology based on cytokine adsorption in the treatment of sepsis. Sixty patients with sepsis were randomly divided into control (<jats:italic>n<\/jats:italic> = 30) and experimental (<jats:italic>n<\/jats:italic> = 30) groups. Both groups were given routine treatment and continuous venovenous hemofiltration, and on this basis, the experimental group received acrylonitrile\/sodium methacrylate (AN69ST) blood purification. The levels of C-reactive protein, procalcitonin, white blood cell count, albumin, platelets, total bilirubin, creatinine, lactic acid, and APACE II score, as well as secretion of inflammatory factors interleukin (IL)-6 and tumor necrosis factor (TNF-\u03b1) were compared. The hospitalization time, mechanical ventilation (MV) time, drug use time, and mortality were analyzed. After treatment, the secretion levels of IL-6 and TNF-\u03b1 were decreased, and other indicators were significantly improved compared with those before treatment (<jats:italic>P<\/jats:italic> &lt; 0.05), especially in the experimental group (<jats:italic>P<\/jats:italic> &lt; 0.05). The hospitalization time, MV time, and drug use time in the experimental group were significantly lower than those of the control group (<jats:italic>P<\/jats:italic> &lt; 0.05), and the mortality was lower than that in the control group (<jats:italic>P<\/jats:italic> &lt; 0.05). In conclusion, blood purification technology based on cytokine adsorption can significantly improve various indicators of sepsis patients, reduce hospitalization time, reduce mortality, and improve the prognosis.<\/jats:p>","DOI":"10.1515\/med-2023-0784","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T16:40:53Z","timestamp":1694536853000},"source":"Crossref","is-referenced-by-count":6,"title":["Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis"],"prefix":"10.1515","volume":"18","author":[{"given":"Yuqiang","family":"Gao","sequence":"first","affiliation":[{"name":"Intensive Medical Unit, Hainan Medical University , 571199 Haikou , China"},{"name":"Intensive Medical Unit , Hainan General Hospital , Hainan Affiliated Hospital of Hainan Medical University , 570311 , Haikou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Huang","sequence":"additional","affiliation":[{"name":"Intensive Medical Unit , Hainan General Hospital , Hainan Affiliated Hospital of Hainan Medical University , 570311 , Haikou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Yang","sequence":"additional","affiliation":[{"name":"Intensive Medical Unit , Hainan General Hospital , Hainan Affiliated Hospital of Hainan Medical University , 570311 , Haikou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Lei","sequence":"additional","affiliation":[{"name":"Intensive Medical Unit , Hainan General Hospital , Hainan Affiliated Hospital of Hainan Medical University , 570311 , Haikou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingan","family":"Chen","sequence":"additional","affiliation":[{"name":"Intensive Medical Unit , Hainan General Hospital , Hainan Affiliated Hospital of Hainan Medical University , 570311 , Haikou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Guo","sequence":"additional","affiliation":[{"name":"Intensive Medical Unit , Hainan General Hospital , Hainan Affiliated Hospital of Hainan Medical University , 570311 , Haikou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Tian","sequence":"additional","affiliation":[{"name":"Intensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University , No. 19 Xiuhua Road, 570311 Haikou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Gao","sequence":"additional","affiliation":[{"name":"Intensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University , No. 19 Xiuhua Road, 570311 Haikou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"2023091216404214627_j_med-2023-0784_ref_001","doi-asserted-by":"crossref","unstructured":"Cecconi M, Evans L, Levy M, Rhodes A. 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