{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:17:27Z","timestamp":1780082247320,"version":"3.54.0"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intensive care units (ICUs) are expert hospital areas that provide treatment and 24\u2009h care for people who are very sick. Sepsis represents a serious, severe condition and it can lead to septic shock and multiple organ dysfunction syndromes and is one of the most common reasons for patients\u2019 hospitalization in ICUs. We wanted to explore the prognostic values of interleukin (IL) 33, soluble suppression of tumorigenicity 2 (sST2), IL 27, and galectin 3 in critically-ill patients. We assumed that these parameters in combination or alone could predict mortality in ICU patients. This research represents a clinical non-randomized prospective study, performed at the Medical Military Academy, a tertiary care hospital in Belgrade, Serbia. The patients were divided in four groups: patients with sepsis (peritonitis, pancreatitis, trauma) and patients without sepsis (trauma). Total number of patients enrolled in the study was 151 and average years of patients were 56.48. The values greater than the cut-off were the predictors of mortality. The IL-33, IL-27 as well as galectin-3 can successfully predict the outcome of critically-ill patients in ICUs. The sST2, cannot predict death in critically-ill patients as a single prognostic factor. However, the combination of at least two biomarkers: IL-33, sST2, IL-27, and galectin-3, gives very significant results in predicting the outcome in patients admitted to ICUs.<\/jats:p>","DOI":"10.1515\/med-2023-0859","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T09:21:20Z","timestamp":1703150480000},"source":"Crossref","is-referenced-by-count":6,"title":["Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units"],"prefix":"10.1515","volume":"18","author":[{"given":"Stevan","family":"Eric","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation, University Clinical Center Kragujevac , Kragujevac , Serbia"},{"name":"Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radica Zivkovic","family":"Zaric","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasna","family":"Jevdjic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, University Clinical Center Kragujevac , Kragujevac , Serbia"},{"name":"Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana Miletic","family":"Drakulic","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Stanojevic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the Military Medical Academy, University of Defense , Belgrade , Serbia"},{"name":"Insitute for Medical Research, Military Medical Academy , Belgrade , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Vojvodic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the Military Medical Academy, University of Defense , Belgrade , Serbia"},{"name":"Insitute for Medical Research, Military Medical Academy , Belgrade , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Arsenijevic","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Markovic","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Zaric","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Canovic","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Nesic","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia"},{"name":"Department of Endocrinology, University Clinical Center Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Zornic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, University Clinical Center Kragujevac , Kragujevac , Serbia"},{"name":"Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac , Kragujevac , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"2023122109211709509_j_med-2023-0859_ref_001","doi-asserted-by":"crossref","unstructured":"Wang Y, Zhao J, Yao Y, Zhao D, Liu S. Interleukin-27 as a diagnostic biomarker for patients with sepsis: a meta-analysis. Biomed Res Int. 2021;2021:5516940. 10.1155\/2021\/5516940.","DOI":"10.1155\/2021\/5516940"},{"key":"2023122109211709509_j_med-2023-0859_ref_002","doi-asserted-by":"crossref","unstructured":"Singer M, Deutschman C, Seymour C, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801\u201310.","DOI":"10.1001\/jama.2016.0287"},{"key":"2023122109211709509_j_med-2023-0859_ref_003","doi-asserted-by":"crossref","unstructured":"Samraj R, Zingarelli B, Wong H. Role of biomarkers in sepsis care. Shock. 2013;40:358\u201365.","DOI":"10.1097\/SHK.0b013e3182a66bd6"},{"key":"2023122109211709509_j_med-2023-0859_ref_004","doi-asserted-by":"crossref","unstructured":"Arkader R, Troster EJ, Lopes MR, J\u00fanior RR, Carcillo JA, Leone C, et al. Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome. Arch Dis Child. 2006;91:117\u201320.","DOI":"10.1136\/adc.2005.077446"},{"key":"2023122109211709509_j_med-2023-0859_ref_005","doi-asserted-by":"crossref","unstructured":"Kim H, Hur M, Moon HW, Yun YM, Di Somma S. Great network. Multi-marker approach using procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis. Ann Intensive Care. 2017;7(1):27. 10.1186\/s13613-017-0252-y.","DOI":"10.1186\/s13613-017-0252-y"},{"key":"2023122109211709509_j_med-2023-0859_ref_006","doi-asserted-by":"crossref","unstructured":"Krychtiuk KA, Stojkovic S, Lenz M, Brekalo M, Huber K, Wojta J, et al. Predictive value of low interleukin-33 in critically ill patients. Cytokine. 2018;103:109\u201313. 10.1016\/j.cyto.2017.09.017.","DOI":"10.1016\/j.cyto.2017.09.017"},{"key":"2023122109211709509_j_med-2023-0859_ref_007","doi-asserted-by":"crossref","unstructured":"Hur M, Kim H, Kim HJ, Yang HS, Magrini L, Marino R, et al. Soluble ST2 has a prognostic role in patients with suspected sepsis. Ann Lab Med. 2015;35(6):570\u20137. 10.3343\/alm.2015.35.6.570.","DOI":"10.3343\/alm.2015.35.6.570"},{"key":"2023122109211709509_j_med-2023-0859_ref_008","doi-asserted-by":"crossref","unstructured":"Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity. 2002;16:779\u201390.","DOI":"10.1016\/S1074-7613(02)00324-2"},{"key":"2023122109211709509_j_med-2023-0859_ref_009","doi-asserted-by":"crossref","unstructured":"Dong R, Zhang M, Hu Q, Zheng S, Soh A, Zheng Y, et al. Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review). Int J Mol Med. 2018;41:599\u2013614.","DOI":"10.3892\/ijmm.2017.3311"},{"key":"2023122109211709509_j_med-2023-0859_ref_010","doi-asserted-by":"crossref","unstructured":"Newlaczyl AU, Yu LG. Galectin-3-a jack-of-all-trades in cancer. Cancer Lett. 2011;313:123\u20138.","DOI":"10.1016\/j.canlet.2011.09.003"},{"key":"2023122109211709509_j_med-2023-0859_ref_011","doi-asserted-by":"crossref","unstructured":"Jevdjic J, Surbatovic M, Milosavljevic S, Rondovic G, Stanojevic I, Eric S, et al. Galectin-3 in critically ill patients with sepsis and\/or trauma: a good predictor of outcome or not?. Serb J Exp Clin Res. 2021;22:21\u20137.","DOI":"10.2478\/sjecr-2018-0037"},{"key":"2023122109211709509_j_med-2023-0859_ref_012","doi-asserted-by":"crossref","unstructured":"Wettersten N, Maisel AS. Biomarkers for heart failure: an update for practitioners of internal medicine. Am J Med. 2016;129(6):560\u20137. 10.1016\/j.amjmed.2016.01.013.","DOI":"10.1016\/j.amjmed.2016.01.013"},{"key":"2023122109211709509_j_med-2023-0859_ref_013","doi-asserted-by":"crossref","unstructured":"Lalive PH, Kreutzfeldt M, Devergne O, Metz I, Bruck W, Merkler D, et al. Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients. J Neuroinflammation. 2017;14:144.","DOI":"10.1186\/s12974-017-0919-1"},{"key":"2023122109211709509_j_med-2023-0859_ref_014","doi-asserted-by":"crossref","unstructured":"Ogura T, Nakamura Y, Takahashi K, Nishida K, Kobashi D, Matsui S. Treatment of patients with sepsis in a closed intensive care unit is associated with improved survival: a nationwide observational study in Japan. J Intensive Care. 2018;6:57. 10.1186\/s40560-018-0322-8.","DOI":"10.1186\/s40560-018-0322-8"},{"key":"2023122109211709509_j_med-2023-0859_ref_015","doi-asserted-by":"crossref","unstructured":"Sakr Y, Jaschinski U, Wittebole X, Szakmany T, Lipman J, \u00d1amendys-Silva S, et al. Sepsis in intensive care unit patients: worldwide data from the intensive care over nations audit. Open Forum Infect Dis. 2018;5:12.","DOI":"10.1093\/ofid\/ofy313"},{"key":"2023122109211709509_j_med-2023-0859_ref_016","doi-asserted-by":"crossref","unstructured":"Nasir N, Jamil B, Siddiqui S, Talat N, Khan FA, Hussain R. Mortality in sepsis and its relationship with gender. Pak J Med Sci. 2015;31(5):1201\u20136. 10.12669\/pjms.315.6925.","DOI":"10.12669\/pjms.315.6925"},{"key":"2023122109211709509_j_med-2023-0859_ref_017","doi-asserted-by":"crossref","unstructured":"Allyn J, Ferdynus C, Bohrer M, Dalban C, Valance D, Allou N. Simplified acute physiology score II as predictor of mortality in intensive care units: a decision curve analysis. PLoS One. 2016;11(10):e0164828. 10.1371\/journal.pone.0164828.","DOI":"10.1371\/journal.pone.0164828"},{"key":"2023122109211709509_j_med-2023-0859_ref_018","doi-asserted-by":"crossref","unstructured":"Sadaka F, EthmaneAbouElMaali C, Cytron MA, Fowler K, Javaux VM, O\u2019Brien J. Predicting mortality of patients with sepsis: a comparison of APACHE II and APACHE III scoring systems. J Clin Med Res. 2017;9(11):907\u201310. 10.14740\/jocmr3083w.","DOI":"10.14740\/jocmr3083w"},{"key":"2023122109211709509_j_med-2023-0859_ref_019","doi-asserted-by":"crossref","unstructured":"Jones AE, Trzeciak S, Kline JA. The sequential organ failure assessment scores for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med. 2009;37(5):1649\u201354. 10.1097\/CCM.0b013e31819def97.","DOI":"10.1097\/CCM.0b013e31819def97"},{"key":"2023122109211709509_j_med-2023-0859_ref_020","doi-asserted-by":"crossref","unstructured":"Nascimento DC, Melo PH, Pi\u00f1eros AR, Ferreira RG, Col\u00f3n DF, Donate PB, et al. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. Nat Commun. 2017;8:14919. 10.1038\/ncomms14919.","DOI":"10.1038\/ncomms14919"},{"key":"2023122109211709509_j_med-2023-0859_ref_021","doi-asserted-by":"crossref","unstructured":"Morrow KN, Coopersmith CM, Ford ML. IL-17, IL-27, and IL-33: a novel axis linked to immunological dysfunction during sepsis. Front Immunol. 2019;10:2019. 10.3389\/fimmu.2019.01982.","DOI":"10.3389\/fimmu.2019.01982"},{"key":"2023122109211709509_j_med-2023-0859_ref_022","doi-asserted-by":"crossref","unstructured":"Erenler AK, Baydin A. Interleukin-33 (IL-33) as a diagnostic and prognostic factor in traumatic brain injury. Emerg Med Int. 2020;2020:1832345. 10.1155\/2020\/1832345.","DOI":"10.1155\/2020\/1832345"},{"key":"2023122109211709509_j_med-2023-0859_ref_023","doi-asserted-by":"crossref","unstructured":"Sun H, Jiang H, Eliaz A, Kellum JA, Peng Z, Eliaz I. Galectin-3 in septic acute kidney injury: a translational study. Crit Care. 2021;25(1):109. 10.1186\/s13054-021-03538-0.","DOI":"10.1186\/s13054-021-03538-0"},{"key":"2023122109211709509_j_med-2023-0859_ref_024","doi-asserted-by":"crossref","unstructured":"Mishra BB, Li Q, Steichen AL, Binstock BJ, Metzger DW, Teale JM, et al. Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia. PLoS One. 2013;8(3):e59616. 10.1371\/journal.pone.0059616.","DOI":"10.1371\/journal.pone.0059616"}],"container-title":["Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2023-0859\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2023-0859\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T09:21:33Z","timestamp":1703150493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/med-2023-0859\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12,21]]},"published-print":{"date-parts":[[2023,12,21]]}},"alternative-id":["10.1515\/med-2023-0859"],"URL":"https:\/\/doi.org\/10.1515\/med-2023-0859","relation":{},"ISSN":["2391-5463"],"issn-type":[{"value":"2391-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,1]]},"article-number":"20230859"}}