{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:53:40Z","timestamp":1753887220698,"version":"3.41.2"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Eosinophilic gastrointestinal diseases (EGIDs) are rare and heterogeneous diseases characterized by excessive eosinophilic infiltration of the digestive system. D-dimer levels and its possible association with disease course were not reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case series<\/jats:title>\n                  <jats:p>We reported a series of three EGID cases presenting with high levels of D-dimer. No evidence for potential venous thromboembolism was found through computed tomography pulmonary angiogram and vascular ultrasounds. Moreover, D-dimer levels decreased after short-time systemic prednisolone administration, accompanied by remission of clinical symptoms and decrease of peripheral eosinophil counts and IgE levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Elevation of D-dimer in EGID may not represent thrombotic events but is possibly associated with disease severity. More population-based studies are needed to delineate the potential relationship among D-dimer, thrombosis, and inflammation in EGID.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/med-2024-0960","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T17:12:01Z","timestamp":1715620321000},"source":"Crossref","is-referenced-by-count":0,"title":["Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review"],"prefix":"10.1515","volume":"19","author":[{"given":"Yang","family":"Song","sequence":"first","affiliation":[{"name":"Yantai Nurses School of Shandong , Yantai , Shandong , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Qingdao Hospital, University of Health and Rehabilitation (Qingdao Municipal Hospital) , Qingdao , Shandong 266000 , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanlei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital) , Qingdao , Shandong , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doudou","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Qingdao Hospital, University of Health and Rehabilitation (Qingdao Municipal Hospital) , Qingdao , Shandong 266000 , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"2024060509334642148_j_med-2024-0960_ref_001","unstructured":"Dellon ES, Gonsalves N, Abonia JP, Alexander JA, Arva NC, Atkins D, et al. International consensus recommendations for eosinophilic gastrointestinal disease nomenclature. Clin Gastroenterol Hepatol. 2022;20(11):2474\u201384.e3. 10.1016\/j.cgh.2022.02.017."},{"key":"2024060509334642148_j_med-2024-0960_ref_002","doi-asserted-by":"crossref","unstructured":"Gonsalves N. Eosinophilic gastrointestinal disorders. Clin Rev Allergy Immunol. 2019;57(2):272\u201385. 10.1007\/s12016-019-08732-1.","DOI":"10.1007\/s12016-019-08732-1"},{"key":"2024060509334642148_j_med-2024-0960_ref_003","doi-asserted-by":"crossref","unstructured":"Hua S, Cook D, Walker MM, Talley NJ. Pharmacological treatment of eosinophilic gastrointestinal disorders. Expert Rev Clin Pharmacol. 2016;9(9):1195\u2013209. 10.1080\/17512433.2016.1190268.","DOI":"10.1080\/17512433.2016.1190268"},{"key":"2024060509334642148_j_med-2024-0960_ref_004","doi-asserted-by":"crossref","unstructured":"Lee J, Dierkhising R, Wu TT, Alexander J, Weiler C. Eosinophilic gastrointestinal disorders (EGID) with peripheral eosinophilia: a retrospective review at Mayo Clinic. 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