{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:21:21Z","timestamp":1776846081702,"version":"3.51.2"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To summarize the clinical characteristics, diagnosis, and treatment experience of human immunodeficiency virus (HIV) infection combined with acute leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten patients with HIV infection (eight males, two females; mean age of 40 years) were diagnosed with acute leukemia. Clinical features, diagnosis, treatment, and outcomes of these patients were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among these ten patients, eight acute myeloid leukemia cases and two acute lymphoblastic leukemia cases were L3; three cases of M3 were positive for the promyelocytic leukemia and Vitamin A acid receptor alpha (PML\/RARA) fusion genes, and four cases presented multiple chromosomal structural and numerical abnormalities. CD4+ T cell counts of the ten patients ranged from 84 to 389 cells\/\u03bcL with a mean of 253.5 cells\/\u03bcL. Among six patients who received chemotherapy, three cases were alive, two died of sepsis secondary to myelosuppression after chemotherapy, and one was lost to follow-up. Among four patients who did not receive chemotherapy, three died, one had M3 treatment and died with cerebral hemorrhage, and one was lost to follow-up. The maximum survival time was 74 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HIV combined with acute leukemia has a complex presentation and rapid progression, early diagnosis and timely initiation of standard chemotherapy along with active antiviral therapy can improve patient\u2019s survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2024-1081","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T08:47:01Z","timestamp":1740386821000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinical analysis of ten cases of HIV infection combined with acute leukemia"],"prefix":"10.1515","volume":"20","author":[{"given":"Shanshan","family":"Fan","sequence":"first","affiliation":[{"name":"Second Department of Infection Disease, Yunnan Provincial Infectious Disease Hospital , Kunming , Yunnan 650301 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Qian","sequence":"additional","affiliation":[{"name":"Second Department of Infection Disease, Yunnan Provincial Infectious Disease Hospital , Kunming , Yunnan 650301 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Tao","sequence":"additional","affiliation":[{"name":"Second Department of Infection Disease, Yunnan Provincial Infectious Disease Hospital , Kunming , Yunnan 650301 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Second Department of Infection Disease, Yunnan Provincial Infectious Disease Hospital , Kunming , Yunnan 650301 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Lin","sequence":"additional","affiliation":[{"name":"Second Department of Infection Disease, Yunnan Provincial Infectious Disease Hospital , Kunming , Yunnan 650301 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konglong","family":"Li","sequence":"additional","affiliation":[{"name":"Second Department of Infection Disease, Yunnan Provincial Infectious Disease Hospital , Kunming , Yunnan 650301 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Department of Infection Disease, Yunnan Provincial Infectious Disease Hospital , Kunming , Yunnan 650301 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Min","sequence":"additional","affiliation":[{"name":"Second Department of Infection Disease, Yunnan Provincial Infectious Disease Hospital , Kunming , Yunnan 650301 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"2025122201303418010_j_med-2024-1081_ref_001","doi-asserted-by":"crossref","unstructured":"Trab T, Baech J, Jakobsen LH, Husby S, Severinsen MT, Eloranta S, et al. 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