{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:06:00Z","timestamp":1772190360818,"version":"3.50.1"},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. Natural sources like plants are currently being explored for its antiangiogenic activity as they are factories of various phytochemicals. The goal of the current study is to investigate the antiangiogenic potential of\n                      <jats:italic>Elaeagnus umbellata<\/jats:italic>\n                      (\n                      <jats:italic>E. umbellata<\/jats:italic>\n                      ) by using chorioallantoic membrane (CAM) assay and molecular docking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on our previous research, the antiangiogenic activity was carried out using active fractions including crude methanol (Eu-Met), ethyl acetate (Eu-EtAc), and chloroform (Eu-Chf) extracts using CAM assay. Furthermore, to understand the binding mechanism of identified compounds, molecular docking was performed against vascular endothelial growth factor receptor 2 (VEGFR-2) using AutoDock vina as docking software. VEGFR-2 is overexpressed in pathological angiogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In CAM assay, Eu-Met, Eu-EtAc, and Eu-Chf extracts showed antiangiogenic activities but notable antiangiogenic activities were exhibited by Eu-Chf with IC\n                      <jats:sub>50<\/jats:sub>\n                      value of 65.02\u2009\u03bcg\/mL. In molecular docking, five compounds, catechin, catechin hydrate, morin, quercetin, and rutin, reported in the extract and active fractions (Eu-Met, Eu-EtAc, and Eu-Chf) of\n                      <jats:italic>E. umbellata<\/jats:italic>\n                      showed strong interactions with VEGFR-2 with binding affinities of \u22129.4, \u22129.3, \u22129.9, \u221210.2, and \u22129.4\u2009kcal\/mol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Based on our results, we can claim that\n                      <jats:italic>E. umbellata<\/jats:italic>\n                      possess antiangiogenic activity which needs to be explored further.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2024-1083","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:41:21Z","timestamp":1737013281000},"source":"Crossref","is-referenced-by-count":1,"title":["Antiangiogenic potential of\n                    <i>Elaeagnus umbellata<\/i>\n                    extracts and molecular docking study by targeting VEGFR-2 pathway"],"prefix":"10.1515","volume":"20","author":[{"given":"Nausheen","family":"Nazir","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Malakand , Chakdara Dir Lower 18800 , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arbaz","family":"Waqar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Malakand , Chakdara Dir Lower 18800 , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Zaib Khan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Malakand , Chakdara Dir Lower 18800 , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaz","family":"Ali Khan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Malakand , Chakdara Dir Lower 18800 , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Aziz","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Health Food Hygiene and Quality, University of Ioannina , Arta , Greece"},{"name":"Institute of Molecular Biology and Biotechnology, The University of Lahore , Punjab , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah F.","family":"Alasmari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"2025122201304620347_j_med-2024-1083_ref_001","doi-asserted-by":"crossref","unstructured":"Kretschmer M, R\u00fcdiger D, Zahler S. 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