{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:04:26Z","timestamp":1780095866175,"version":"3.54.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study comprehensively analyzes the pharmacological effects of ethanolic extract of\n                      <jats:italic>Apteranthes tuberculata<\/jats:italic>\n                      (EEAT) on various physiological parameters in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The research aimed to quantify flavonoid and phenol contents across different extraction methods, with a focus on the superior efficacy of the ethanolic extract.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      assays were conducted to assess the antioxidant activity of EEAT, revealing dose-dependent effects and significant inhibition percentages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EEAT exhibited notable analgesic effects in the writhing response test, particularly at 200\u2009mg\/kg, indicating its potential as a natural analgesic. Additionally, its anti-inflammatory effects were complex and dose-dependent in a carrageenan-induced paw edema model. The extract also showed significant changes in body temperature regulation following Brewer\u2019s yeast-induced fever, revealing a distinct pattern of initial hypothermia followed by gradual re-elevation. Furthermore, EEAT demonstrated regulatory effects on gastrointestinal motility, with higher doses enhancing intestinal transit in charcoal meal tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the pharmacological potential of EEAT as a natural therapeutic agent for antioxidant, analgesic, anti-inflammatory, and gastrointestinal regulation, warranting further investigation into its mechanisms of action and therapeutic applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2024-1092","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T14:29:13Z","timestamp":1748960953000},"source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive biomedicine assessment of\n                    <i>Apteranthes tuberculata<\/i>\n                    extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models"],"prefix":"10.1515","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7425-1557","authenticated-orcid":false,"given":"Sajida","family":"Afzal","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering (Medicine), Shenzhen University , Shenzhen , 518060, Guangdong , China"},{"name":"Shenzhen Hospital , Shenzhen , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-5933","authenticated-orcid":false,"given":"Siraj","family":"Khan","sequence":"additional","affiliation":[{"name":"Qarshi Herb Research Center at Qarshi Industries (Pvt.) Ltd , Haripur , Hattar , Pakistan"},{"name":"Qarshi University , Lahore , 54000 , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-7202","authenticated-orcid":false,"given":"Muhammad Imam","family":"Ammarullah","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Faculty of Engineering, Universitas Diponegoro , Semarang , 50275, Central Java , Indonesia"},{"name":"Undip Biomechanics Engineering & Research Centre (UBM-ERC), Universitas Diponegoro , Semarang , 50275, Central Java , Indonesia"},{"name":"Bioengineering and Environmental Sustainability Research Centre, University of Liberia , Monrovia , 1000, Montserrado , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"2026052922504836506_j_med-2024-1092_ref_001","doi-asserted-by":"crossref","unstructured":"Dar RA, Shahnawaz M, Ahanger MA, Majid I. 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