{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:52:08Z","timestamp":1787867528575,"version":"build-2784847793"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chromoblastomycosis (CBM) is a chronic neglected fungal disease that causes serious damage to the physical and mental health of patients. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has garnered significant attention in the recent era for the treatment of CBM and has exhibited promising effects in several clinical case reports. We established a mice footpad infection model with\n                    <jats:italic>Fonsecaea monophora<\/jats:italic>\n                    and analyzed the impact of PDT treatment on the immune response of macrophages using single-cell sequencing. The results showed that infection of the mouse footpad skin with\n                    <jats:italic>F. monophora<\/jats:italic>\n                    results in an increase in inflammatory cells, primarily mononuclear-macrophages, with the activation of complement and enhancement of cell chemotaxis, leading to upregulation of anti-infection-related pathways. After ALA-PDT treatment, the number of inflammatory cells decreased, while macrophages upregulated the expression of antigen-recognition-related genes, enhancing phagocytosis and autophagy-related biological functions.\n                  <\/jats:p>","DOI":"10.1515\/med-2024-1132","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:11:06Z","timestamp":1736766666000},"source":"Crossref","is-referenced-by-count":3,"title":["Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with\n                    <i>Fonsecaea monophora<\/i>\n                    based on single-cell sequencing"],"prefix":"10.1515","volume":"20","author":[{"given":"Wenyi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Danish","family":"Yaqoob","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuling","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University , 183 West Zhongshan Road , Guangzhou , China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"2025122201303421655_j_med-2024-1132_ref_001","doi-asserted-by":"crossref","unstructured":"Santos D, de Azevedo C, Vicente VA, Queiroz-Telles F, Rodrigues AM, de Hoog GS, et al. 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