{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:38:09Z","timestamp":1768448289690,"version":"3.49.0"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertension is a risk factor for cardiovascular disease. The present study aimed to explore the impact of ambulatory blood pressure load (BPL) on mitral regurgitation (MR) in continuous ambulatory peritoneal dialysis (CAPD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 215 CAPD patients hospitalized in the Department of Nephrology at the Fifth Affiliated Hospital of Sun Yat-sen University between November 2017 and June 2022 were included in the study. All subjects underwent 24-h ambulatory BP monitoring and an echocardiography examination. BPL and MR area (MRA) were calculated. Subjects were divided into high regurgitation group and non-high regurgitation group. General data were also collected. The effect of ambulatory BPL on MR in CAPD patients was analyzed using multiple linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline data comparison revealed statistically significant differences in hemoglobin, serum \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -microglobulin, NT-proBNP, left atrial diameter (LAD), left ventricular end-diastolic diameter (LVDD), LV ejection fraction (LVEF), LV fractional shortening (LVFS), and mitral valve calcification between the high and non-high regurgitation groups (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). There was no statistically significant difference in other clinical characteristics. Correlation analysis showed correlations between MRA and 24-h systolic BPL (24h-SBPL), 24-h diastolic BPL (24h-DBPL), daytime systolic BPL (D-SBPL), daytime DBPL (D-DBPL), nighttime systolic BPL (N-SBPL), nighttime DBPL (N-DBPL), hemoglobin level, NT-proBNP level, LAD, LVDD, LVEF, and LVFS. Multiple linear regression analysis revealed that the effects of 24h-DBPL and D-DBPL on MRA were statistically significantly different (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ambulatory BPL, particularly 24h-DBPL and D-DBPL, significantly affected MR. Therefore, controlling BPL, especially DBPL, was essential for reducing the incidence of cardiovascular events and clinical mortality in CAPD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2025-1155","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T17:45:17Z","timestamp":1743529517000},"source":"Crossref","is-referenced-by-count":1,"title":["The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients"],"prefix":"10.1515","volume":"20","author":[{"given":"Qingyun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai , Guang Dong Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinqiang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai , Guang Dong Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongxia","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai , Guang Dong Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bairong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University , Zhuhai , Guang Dong Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai , Guang Dong Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"2025122201303467098_j_med-2025-1155_ref_001","doi-asserted-by":"crossref","unstructured":"Inker LA, Astor BC, Fox CH, Isakova T, Lash JP, Peralta CA, et al. 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