{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T01:36:36Z","timestamp":1766367396315,"version":"3.48.0"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peripheral conditioning induces transient ischemia, promoting antioxidant production in ischemia-affected tissues, which helps reduce heart reperfusion injury in ST-elevation myocardial infarction (STEMI) patients. This study compares troponin and creatine kinase-MB (CK-MB) levels among STEMI patients with and without remote conditioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 160 patients treated for STEMI at a tertiary care centre. The study protocol involved cyclic inflation and deflation of a blood pressure cuff on the brachial region in four cycles of 5\u2009min each. Markers of myocardial necrosis, CK-MB, and troponin, were monitored before percutaneous coronary intervention (PCI), immediately after, and at 24, 48, and 72\u2009h post-PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CK-MB and troponin levels were significantly lower in non-diabetic patients who underwent remote peripheral conditioning compared to those who did not, with significant reductions observed after PCI (CK-MB:\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001; troponin:\n                      <jats:italic>p<\/jats:italic>\n                      = 0.033), and at 24 (CK-MB:\n                      <jats:italic>p<\/jats:italic>\n                      = 0.015; troponin:\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001) and 48\u2009h post-PCI (troponin:\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). In the second phase, no significant differences in CK-MB or troponin levels were found between diabetic patients with and without conditioning. However, a trend toward lower values was noted in the conditioned group. In the third phase, significant reductions in CK-MB (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) and troponin levels (after PCI:\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007; 24\u2009h post-PCI:\n                      <jats:italic>p<\/jats:italic>\n                      = 0.045) were observed across all patients who underwent conditioning compared to the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peripheral pre- and post-conditioning is an economical, simple, and physiological method that effectively prevents and reduces heart damage caused by reperfusion injury, particularly in non-diabetic STEMI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2025-1175","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T17:40:20Z","timestamp":1743529220000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients"],"prefix":"10.1515","volume":"20","author":[{"given":"Veljko","family":"Andric","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia"},{"name":"Department of Internal Medicine, Health Center Ra\u0161ka , Raska , Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radica Zivkovic","family":"Zaric","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, University of Kragujevac , Svetozara Markovica 69 , Kragujevac , Serbia"},{"name":"Department of Pharmacology and Toxicology, University Clinical Centre Kragujevac , Kragujevac , Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusan","family":"Andric","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Children\u2019s Clinic , Belgrade , Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovan","family":"Petrovic","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Internal Medicine, Vascular Surgery Clinic, Institute for Cardiovascular Diseases \u201cDedinje\u201d , Belgrade , Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Davidovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia"},{"name":"Department of Internal Medicine, Faculty of Medical Sciences University of Kragujevac, University Clinical Centre Kragujevac , Kragujevac , Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"2025122201304621515_j_med-2025-1175_ref_001","doi-asserted-by":"crossref","unstructured":"Li Y, Gao Y, Li G. 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