{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:52:11Z","timestamp":1783745531669,"version":"3.55.0"},"reference-count":43,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Polyphenols are a group of compounds identified as secondary metabolites of plants, with 8,000 types identified to date. Previous research findings have indicated the potential anti-inflammatory properties of polyphenols, with studies suggesting a reduction in disease risk and therapeutic benefits observed in various diseases, including diabesity, neurodegeneration, cancer, and cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to comprehensively analyze the polyphenol composition of extracts of Greek mountain tea (GMT) and wheat germ (WG) and investigate their effects on microcirculation and eicosanoid metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The polyphenol and spermidine composition of GMT and WGE was analyzed using LC\u2013HRMS. Hemodynamic impact of GMT or WG on rat cremasteric arteriole blood flow was measured after compound administration using a laser Doppler blood flow meter. Lipidomic analysis in urine after co-administration of GMT and WGE was measured by LC\u2013HRMS mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study shows that GMT contains large amount of polyphenols, expecially ferulic acid and petunidin. In contrast, in the WG extract we found minimal polyphenol content. Subsequent to the administration of GMT to rats, a significant increase in rat cremasteric arteriole blood flow was observed, while WG extract exhibited minimal change. Following a single oral administration of GMT or WG to mice, 24\u2009h urine was analyzed for eicosanoids. A significant decrease in pro-inflammatory eicosanoids and a substantial increase in anti-inflammatory eicosanoids were observed in the treatment group compared with the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the established role of polyphenol intake in enhancing vascular endothelial function and increasing peripheral blood flow, we suggest that the observed increase in blood flow is a consequence of polyphenols in GMT. In contrast, the enhancement of eicosanoid balance was more pronounced in the WG extract group compared to the GMT group, suggesting that this effect may be attributable to components other than polyphenols present in these fractions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2025-1192","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:30:56Z","timestamp":1747222256000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals"],"prefix":"10.1515","volume":"20","author":[{"given":"Licia","family":"Pantano","sequence":"first","affiliation":[{"name":"Food Department, Istituto Zooprofilattico Sperimentale della Sicilia , Palermo , 90129 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kento","family":"Hiroki","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Engineering, Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology , 307 Fukasaku , Minumaku , Saitama, 337-8570 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashiyu","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Engineering, Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology , 307 Fukasaku , Minumaku , Saitama, 337-8570 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Osada","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Engineering, Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology , 307 Fukasaku , Minumaku , Saitama, 337-8570 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Fujii","sequence":"additional","affiliation":[{"name":"SIT Research Laboratories, Shibaura Institute of Technology , Saitama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Maiolino","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical Advanced Technologies \u201cG. 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Ingrassia\u201d, University of Catania , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula M.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Institute of Regeneration and Prevention, Healthcare AG , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Cammilleri","sequence":"additional","affiliation":[{"name":"Food Department, Istituto Zooprofilattico Sperimentale della Sicilia , Palermo , 90129 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Hippe","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Vienna , Vienna , 1090 , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi M.","family":"Lo Dico","sequence":"additional","affiliation":[{"name":"Food Department, Istituto Zooprofilattico Sperimentale della Sicilia , Palermo , 90129 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Ferrantelli","sequence":"additional","affiliation":[{"name":"Food Department, Istituto Zooprofilattico Sperimentale della Sicilia , Palermo , 90129 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Osakabe","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Engineering, Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology , 307 Fukasaku , Minumaku , Saitama, 337-8570 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"2025122201305414488_j_med-2025-1192_ref_001","doi-asserted-by":"crossref","unstructured":"Arts IC, Hollman PC. 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