{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:08:23Z","timestamp":1787656103731,"version":"build-2736575974"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Uterine fibroids (UF) affect up to 70\u201380% of women by age 50 and are associated with heavy menstrual bleedings, pelvic discomfort, and reduced quality of life. Uterine artery embolization (UAE) is a minimally invasive procedure that aims to reduce fibroid-related symptoms and improve patients\u2019 quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A prospective single-center study was conducted on 40 women who underwent UAE between November 2018 and June 2023. Primary outcomes were evaluated using the Uterine Fibroid Symptom and Quality-of-Life (UFS-QoL) questionnaire to assess symptom severity and health-related quality-of-life scores. Secondary outcomes include pain intensity, complications, requirement of additional treatments, and duration of symptoms after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty-three patients completed the follow-up UFS-QoL questionnaire. The mean age and the mean follow-up time were 47 years (SD 14 years) and 10 months (SD 4 months), respectively. Substantial improvements were observed within all domains of the UFS-QoL questionnaire (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), particularly in symptom severity, where 94% of patients experienced a benefit. All Health Related Quality-of-Life (HRQL) domains statistically significantly improved (73\u201391%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). 67% of patients did not require further treatments. Pelvic pain, according to VAS, improved by 2.1 (0 = much better; 5 = no change; 10 = worse). Post-procedural complications were minor, 70% of patients reported symptoms persisted up to 5 days after discharge, and 88% resolved within 2 weeks. Despite a 45.5% rate of minor complications, including pain and transitory bleeding, 88% of patients would recommend UAE, underlining its safety and effectiveness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>UAE offers substantial benefits for symptomatic fibroids, significantly improving HRQoL, symptom severity and pelvic pain scores, making it a valuable alternative to surgery. Complications were minor and short-lived, and the majority of patients were satisfied with the results, with no need for additional treatments. Further research is warranted to generate peri-procedural pain management consensus guidelines, clinical outcomes of radial access, and fertility-related outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2025-1235","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T15:58:06Z","timestamp":1754582286000},"source":"Crossref","is-referenced-by-count":1,"title":["Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients\u2019 quality of life"],"prefix":"10.1515","volume":"20","author":[{"given":"Nicol\u00f2","family":"Ubaldi","sequence":"first","affiliation":[{"name":"Department of Surgical and Medical Sciences and Translational Medicine, Azienda Ospedaliera Sant\u2019Andrea, Sapienza University of Rome , Rome , Italy"},{"name":"Department of Interventional Radiology, Sant\u2019Andrea Hospital, University La Sapienza , Rome , 00189 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Andrea Tipaldi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Sciences and Translational Medicine, Azienda Ospedaliera Sant\u2019Andrea, Sapienza University of Rome , Rome , Italy"},{"name":"Department of Interventional Radiology, Sant\u2019Andrea Hospital, University La Sapienza , Rome , 00189 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Gynecological, Obstetrical and Urological Sciences, \u201cSapienza\u201d University of Rome , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Golia D\u2019Aug\u00e8","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome , Rome , 00161 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Caserta","sequence":"additional","affiliation":[{"name":"Department of Gynecological, Obstetrical and Urological Sciences, \u201cSapienza\u201d University of Rome , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Simone Lagan\u00e0","sequence":"additional","affiliation":[{"name":"Unit of Obstetrics and Gynecology, Paolo Giaccone Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo , 90127 , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Grasso","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Sciences and Translational Medicine, Azienda Ospedaliera Sant\u2019Andrea, Sapienza University of Rome , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksejs","family":"Zolovkins","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Sant\u2019Andrea Hospital, University La Sapienza , Rome , 00189 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Ronconi","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Sant\u2019Andrea Hospital, University La Sapienza , Rome , 00189 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Sciences and Translational Medicine, Azienda Ospedaliera Sant\u2019Andrea, Sapienza University of Rome , Rome , Italy"},{"name":"Department of Interventional Radiology, Sant\u2019Andrea Hospital, University La Sapienza , Rome , 00189 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"2025122201305050578_j_med-2025-1235_ref_001","doi-asserted-by":"crossref","unstructured":"Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R. Epidemiology of uterine fibroids: A systematic review. BJOG. 2017;124:1501\u201312.","DOI":"10.1111\/1471-0528.14640"},{"key":"2025122201305050578_j_med-2025-1235_ref_002","doi-asserted-by":"crossref","unstructured":"Drayer SM, Catherino WH. Prevalence, morbidity, and current medical management of uterine leiomyomas. Int J Gynaecol Obstet. 2015;131:117\u201322.","DOI":"10.1016\/j.ijgo.2015.04.051"},{"key":"2025122201305050578_j_med-2025-1235_ref_003","doi-asserted-by":"crossref","unstructured":"Guo XC, Segars JH. The impact and management of fibroids for fertility: an evidence-based approach. Obstet Gynecol Clin North Am. 2012;39:521\u201333.","DOI":"10.1016\/j.ogc.2012.09.005"},{"key":"2025122201305050578_j_med-2025-1235_ref_004","doi-asserted-by":"crossref","unstructured":"Giannini A, Golia D\u2019Aug\u00e8 T, Bogani G, Lagan\u00e0 AS, Chiantera V, Vizza E, et al. Uterine sarcomas: A critical review of the literature. Eur J Obstet Gynecol Reprod Biol. 2023;287:166\u201370.","DOI":"10.1016\/j.ejogrb.2023.06.016"},{"key":"2025122201305050578_j_med-2025-1235_ref_005","doi-asserted-by":"crossref","unstructured":"Ravina JH, Herbreteau D, Ciraru-Vigneron N, Bouret JM, Houdart E, Aymard A, et al. Arterial embolisation to treat uterine myomata. Lancet. 1995;346:671\u20132.","DOI":"10.1016\/S0140-6736(95)92282-2"},{"key":"2025122201305050578_j_med-2025-1235_ref_006","doi-asserted-by":"crossref","unstructured":"Khayrutdinov E, Vorontsov I, Arablinskiy A, Shcherbakov D, Gromov D. A randomized comparison of transradial and transfemoral access in uterine artery embolization. Diagn Interv Radiol. 2021;27:59\u201364.","DOI":"10.5152\/dir.2020.19574"},{"key":"2025122201305050578_j_med-2025-1235_ref_007","doi-asserted-by":"crossref","unstructured":"Costantino M, Lee J, McCullough M, Nsouli-Maktabi H, Spies JB. Bilateral versus unilateral femoral access for uterine artery embolization: results of a randomized comparative trial. J Vasc Interv Radiol. 2010;21:829\u201335 quiz 835.","DOI":"10.1016\/j.jvir.2010.01.042"},{"key":"2025122201305050578_j_med-2025-1235_ref_008","doi-asserted-by":"crossref","unstructured":"Rebonato A, Maiettini D, Patriti A, Giurazza F, Tipaldi MA, Piacentino F, et al. Hemorrhoids embolization: State of the art and future directions. J Clin Med. 2021;10:3537.","DOI":"10.3390\/jcm10163537"},{"key":"2025122201305050578_j_med-2025-1235_ref_009","doi-asserted-by":"crossref","unstructured":"van Overhagen H, Reekers JA. Uterine artery embolization for symptomatic leiomyomata. Cardiovasc Intervent Radiol. 2015;38:536\u201342.","DOI":"10.1007\/s00270-014-1031-x"},{"key":"2025122201305050578_j_med-2025-1235_ref_010","doi-asserted-by":"crossref","unstructured":"Kr\u00f6ncke T. An update on uterine artery embolization for uterine leiomyomata and adenomyosis of the uterus. Br J Radiol. 2023;96:20220121.","DOI":"10.1259\/bjr.20220121"},{"key":"2025122201305050578_j_med-2025-1235_ref_011","doi-asserted-by":"crossref","unstructured":"Jun F, Yamin L, Xinli X, Zhe L, Min Z, Bo Z, et al. Uterine artery embolization versus surgery for symptomatic uterine fibroids: A randomized controlled trial and a meta-analysis of the literature. Arch Gynecol Obstet. 2012;285:1407\u201313.","DOI":"10.1007\/s00404-011-2065-9"},{"key":"2025122201305050578_j_med-2025-1235_ref_012","doi-asserted-by":"crossref","unstructured":"Manyonda I, Belli A-M, Lumsden M-A, Moss J, McKinnon W, Middleton LJ, et al. Uterine-artery embolization or myomectomy for uterine fibroids. N Engl J Med. 2020;383:440\u201351.","DOI":"10.1056\/NEJMoa1914735"},{"key":"2025122201305050578_j_med-2025-1235_ref_013","doi-asserted-by":"crossref","unstructured":"Spies JB, Coyne K, Guaou Guaou N, Boyle D, Skyrnarz-Murphy K, Gonzalves SM. The UFS-QOL, a new disease-specific symptom and health-related quality of life questionnaire for leiomyomata. Obstet Gynecol. 2002;99:290\u2013300.","DOI":"10.1097\/00006250-200202000-00021"},{"key":"2025122201305050578_j_med-2025-1235_ref_014","doi-asserted-by":"crossref","unstructured":"Mariara C, Obura T, Hacking N, Stones W. One year symptom severity and health-related quality of life changes among Black African patients undergoing uterine fibroid embolisation. BMC Res Notes. 2017;10:240.","DOI":"10.1186\/s13104-017-2558-0"},{"key":"2025122201305050578_j_med-2025-1235_ref_015","doi-asserted-by":"crossref","unstructured":"Anchan RM, Spies JB, Zhang S, Wojdyla D, Bortoletto P, Terry K, et al. Long-term health-related quality of life and symptom severity following hysterectomy, myomectomy, or uterine artery embolization for the treatment of symptomatic uterine fibroids. Am J Obstet Gynecol. 2023;229:275.e1\u201317.","DOI":"10.1016\/j.ajog.2023.05.020"},{"key":"2025122201305050578_j_med-2025-1235_ref_016","doi-asserted-by":"crossref","unstructured":"Psilopatis I, Fleckenstein FN, Collettini F, Can E, Frisch A, Gebauer B, et al. Short- and long-term evaluation of disease-specific symptoms and quality of life following uterine artery embolization of fibroids. Insights Imaging. 2022;13:106.","DOI":"10.1186\/s13244-022-01244-1"},{"key":"2025122201305050578_j_med-2025-1235_ref_017","doi-asserted-by":"crossref","unstructured":"Kovacsik HV, Herbreteau D, Bommart S, Beregi J-P, Bartoli J-M, Sapoval M, et al. Evaluation of changes in sexual function related to uterine fibroid embolization (UFE): Results of the EFUZEN study. Cardiovasc Intervent Radiol. 2017;40:1169\u201375.","DOI":"10.1007\/s00270-017-1615-3"},{"key":"2025122201305050578_j_med-2025-1235_ref_018","doi-asserted-by":"crossref","unstructured":"Silva NACda, Szejnfeld D, Klajner RK, Mata MVMda, Aun R, Belczak SQ. Improvement in parameters of quality of life and uterine volume reduction after uterine fibroid embolization. Einstein (Sao Paulo). 2020;18:eAO5458.","DOI":"10.31744\/einstein_journal\/2020AO5458"},{"key":"2025122201305050578_j_med-2025-1235_ref_019","doi-asserted-by":"crossref","unstructured":"Spencer EB, Stratil P, Mizones H. Clinical and periprocedural pain management for uterine artery embolization. Semin Intervent Radiol. 2013;30:354\u201363.","DOI":"10.1055\/s-0033-1359729"},{"key":"2025122201305050578_j_med-2025-1235_ref_020","doi-asserted-by":"crossref","unstructured":"du Pisanie JL, Commander CW, Burke CT. Management of postprocedural uterine artery embolization pain. Semin Intervent Radiol. 2021;38:588\u201394.","DOI":"10.1055\/s-0041-1739161"},{"key":"2025122201305050578_j_med-2025-1235_ref_021","doi-asserted-by":"crossref","unstructured":"Giannini A, Cuccu I, D\u2019Auge TG, De Angelis E, Lagan\u00e0 AS, Chiantera V, et al. The great debate: Surgical outcomes of laparoscopic versus laparotomic myomectomy. A meta-analysis to critically evaluate current evidence and look over the horizon. Eur J Obstet Gynecol Reprod Biol. 2024;297:50\u20138.","DOI":"10.1016\/j.ejogrb.2024.03.045"},{"key":"2025122201305050578_j_med-2025-1235_ref_022","doi-asserted-by":"crossref","unstructured":"Waldron MG, Kassamani YW, O\u2019Mahony AT, O\u2019Mahony SM, O\u2019Sullivan OE, Power SP, et al. Uterine artery embolisation of fibroids and the phenomenon of post-embolisation syndrome: A systematic review. Diagnostics (Basel). 2022;12:2916.","DOI":"10.3390\/diagnostics12122916"},{"key":"2025122201305050578_j_med-2025-1235_ref_023","doi-asserted-by":"crossref","unstructured":"Mailli L, Patel S, Das R, Chun JY, Renani S, Das S, et al. Uterine artery embolisation: Fertility, adenomyosis and size - what is the evidence? CVIR Endovasc. 2023;6:8.","DOI":"10.1186\/s42155-023-00353-2"},{"key":"2025122201305050578_j_med-2025-1235_ref_024","doi-asserted-by":"crossref","unstructured":"Katsumori T, Nakajima K, Mihara T. Is a large fibroid a high-risk factor for uterine artery embolization? AJR Am J Roentgenol. 2003;181:1309\u201314.","DOI":"10.2214\/ajr.181.5.1811309"},{"key":"2025122201305050578_j_med-2025-1235_ref_025","doi-asserted-by":"crossref","unstructured":"Gupta JK, Sinha A, Lumsden MA, Hickey M. Uterine artery embolization for symptomatic uterine fibroids. Cochrane Database Syst Rev. 2014;2014:CD005073.","DOI":"10.1002\/14651858.CD005073.pub4"},{"key":"2025122201305050578_j_med-2025-1235_ref_026","doi-asserted-by":"crossref","unstructured":"Borah BJ, Yao X, Laughlin-Tommaso SK, Heien HC, Stewart EA. Comparative effectiveness of uterine leiomyoma procedures using a large insurance claims database. Obstet Gynecol. 2017;130:1047\u201356.","DOI":"10.1097\/AOG.0000000000002331"},{"key":"2025122201305050578_j_med-2025-1235_ref_027","doi-asserted-by":"crossref","unstructured":"Davis MR, Soliman AM, Castelli-Haley J, Snabes MC, Surrey ES. Reintervention rates after myomectomy, endometrial ablation, and uterine artery embolization for patients with uterine fibroids. J Womens Health (Larchmt). 2018;27:1204\u201314.","DOI":"10.1089\/jwh.2017.6752"},{"key":"2025122201305050578_j_med-2025-1235_ref_028","doi-asserted-by":"crossref","unstructured":"Mart\u00edn-Merino E, Garc\u00eda Rodr\u00edguez LA, Wallander M-A, Andersson S, Soriano-Gabarr\u00f3 M. The incidence of hysterectomy, uterus-preserving procedures and recurrent treatment in the management of uterine fibroids. Eur J Obstet Gynecol Reprod Biol. 2015;194:147\u201352.","DOI":"10.1016\/j.ejogrb.2015.08.034"},{"key":"2025122201305050578_j_med-2025-1235_ref_029","doi-asserted-by":"crossref","unstructured":"Tsikouras P, Gkaitatzi F, Gerede A, Anthoulaki X, Bothou A, Chalkidou A, et al. Life quality in premenopausal women after embolization of uterine myomas. J Pers Med. 2022;12:1990.","DOI":"10.3390\/jpm12121990"}],"container-title":["Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/med-2025-1235\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/med-2025-1235\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T01:41:09Z","timestamp":1766367669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/med-2025-1235\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,20]]},"published-print":{"date-parts":[[2025,1,20]]}},"alternative-id":["10.1515\/med-2025-1235"],"URL":"https:\/\/doi.org\/10.1515\/med-2025-1235","relation":{},"ISSN":["2391-5463"],"issn-type":[{"value":"2391-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"article-number":"20251235"}}