{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T01:36:37Z","timestamp":1766367397438,"version":"3.48.0"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study is to characterize gut microbiome alterations in newly diagnosed subacute thyroiditis (SAT) patients, and identify potential microbial signatures associated with SAT and treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fecal samples collected from 20 newly diagnosed SAT patients and 20 healthy controls were analyzed using 16S ribosomal RNA gene sequencing. Bioinformatics analysis was performed to assess alpha and beta diversity, taxonomic composition, and differential abundance of gut microbiota between the groups. Correlations between gut microbiome and clinical parameters were also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Newly diagnosed SAT patients exhibited significant alterations in gut microbiota composition. There was increased abundance of\n                      <jats:italic>Escherichia-Shigella<\/jats:italic>\n                      ,\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Akkermansia<\/jats:italic>\n                      ,\n                      <jats:italic>Veillonella<\/jats:italic>\n                      , and\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      , while the abundance of\n                      <jats:italic>Bacteroidetes<\/jats:italic>\n                      ,\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Prevotella<\/jats:italic>\n                      ,\n                      <jats:italic>Roseburia<\/jats:italic>\n                      , and\n                      <jats:italic>Ruminococcus<\/jats:italic>\n                      were significantly decreased. Prednisolone treatment partially normalized the gut microbiota, with\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      ,\n                      <jats:italic>Lactobacillaceae<\/jats:italic>\n                      ,\n                      <jats:italic>Lactobacillus reuteri<\/jats:italic>\n                      , and\n                      <jats:italic>Prevotella<\/jats:italic>\n                      emerging as key biomarkers in post-treatment SAT. Significant correlations were found between specific gut microbiome and clinical markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SAT is associated with distinct gut microbiome alterations, partially reversible with treatment, which suggest a potential role for the gut microbiome in SAT pathogenesis and treatment response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2025-1291","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:16:02Z","timestamp":1760534162000},"source":"Crossref","is-referenced-by-count":0,"title":["Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment"],"prefix":"10.1515","volume":"20","author":[{"given":"Jiayun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology, 920th Hospital of the Joint Logistics Support Force of the Chinese People\u2019s Liberation Army , Kunming , Yunnan, 650032 , China"},{"name":"Department of Endocrinology, Huize County People\u2019s Hospital , Qujing , Yunnan, 654200 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiasheng","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhujiang Hospital of Southern Medical University , Guangzhou , Guangdong, 510282 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, 920th Hospital of the Joint Logistics Support Force of the Chinese People\u2019s Liberation Army , Kunming , Yunnan, 650032 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, 920th Hospital of the Joint Logistics Support Force of the Chinese People\u2019s Liberation Army , Kunming , Yunnan, 650032 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibing","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, 920th Hospital of the Joint Logistics Support Force of the Chinese People\u2019s Liberation Army , Kunming , Yunnan, 650032 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"2025122201304095710_j_med-2025-1291_ref_001","doi-asserted-by":"crossref","unstructured":"Bhatt A, Haslam A, Prasad V. 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