{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:08:12Z","timestamp":1791378492667,"version":"4.3.2"},"reference-count":111,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infertility is a multifactorial condition that affects both men and women and is influenced by various factors, including overweight and obesity. These conditions, especially in women with polycystic ovary syndrome (PCOS), are strongly associated with hormonal and metabolic imbalances that can impair fertility. Targeted nutritional interventions, such as nutraceutical supplementation, may offer support in improving reproductive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative review was conducted using PubMed, focusing on publications from the past 12 years with the keywords \u201cnutraceutical,\u201d \u201coverweight,\u201d and \u201cinfertility.\u201d The review aimed to identify the main nutraceuticals used in managing infertility and to highlight the importance of a personalized approach tailored to individual patient characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nutraceuticals may represent a safe and cost-effective adjunctive strategy to support fertility in overweight patients, particularly in those with PCOS. Evidence suggests that their effectiveness increases when integrated into a personalized treatment plan based on individual needs and clinical profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review offers an updated overview of nutraceutical use in overweight individuals with infertility, outlining both benefits and limitations. It also addresses the often-overlooked medico-legal aspects of prescribing nutraceuticals, emphasizing the need for ethical and legal awareness when incorporating these interventions into clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2025-1293","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:58:07Z","timestamp":1758805087000},"source":"Crossref","is-referenced-by-count":8,"title":["Supplement strategies for infertility in overweight women: Evidence and legal insights"],"prefix":"10.1515","volume":"20","author":[{"given":"Giuseppe","family":"Gullo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, AOOR Villa Sofia \u2013 Cervello, University of Palermo , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, AOOR Villa Sofia \u2013 Cervello, University of Palermo , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Billone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, AOOR Villa Sofia \u2013 Cervello, University of Palermo , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Chitoran","sequence":"additional","affiliation":[{"name":"General Surgery and Surgical Oncology Department I, Bucharest Institute of Oncology \u201cAl. Trestioreanu\u201d , 022328 , Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Kowalcze","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, Academy of Silesia , 40-555 , Katowice , Poland"},{"name":"Department of Pediatrics in Bytom, Faculty of Health Sciences in Katowice, Medical University of Silesia , 41-902 , Bytom , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Krysiak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia , 40-752 , Katowice , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Vaiarelli","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romualdo","family":"Sciorio","sequence":"additional","affiliation":[{"name":"Fertility Medicine and Gynaecological Endocrinology Unit, Department Woman Mother Child, Lausanne University Hospital , 1011 , Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stamatios","family":"Petousis","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki , 541-24 , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliia","family":"Kotlik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, AOOR Villa Sofia \u2013 Cervello, University of Palermo , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Perino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, AOOR Villa Sofia \u2013 Cervello, University of Palermo , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaspare","family":"Cucinella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, AOOR Villa Sofia \u2013 Cervello, University of Palermo , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Marinelli","sequence":"additional","affiliation":[{"name":"School of Law, Polytechnic University of Marche , 60121 Ancona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"De Paola","sequence":"additional","affiliation":[{"name":"Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome , 00161 , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"2025122201304119123_j_med-2025-1293_ref_001","unstructured":"Infertility Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/infertility (accessed on 17 March 2025)."},{"key":"2025122201304119123_j_med-2025-1293_ref_002","doi-asserted-by":"crossref","unstructured":"Brannigan RE, Hermanson L, Kaczmarek J, Kim SK, Kirkby E, Tanrikut C. 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