{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:25:32Z","timestamp":1783445132324,"version":"3.54.6"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2025-1359_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate whether serum SIRT3 levels can predict postoperative delirium (POD) in elderly patients undergoing general anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2025-1359_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective observational study was conducted on 118 elderly patients who underwent general anesthesia from January 2021 to December 2023. POD was assessed using the Confusion Assessment Method (CAM) within 72\u202fh post-surgery. Serum SIRT3, IL-6, IL-1\u03b2, IL-17, and CRP levels were measured by ELISA. Clinical data including surgical time, anesthesia time, and blood loss were recorded. Statistical analysis was performed using SPSS 25.0 (p&lt;0.05 considered significant).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2025-1359_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to non-POD patients, those with POD had longer surgery and anesthesia durations, lower hemoglobin and albumin levels, significantly lower serum SIRT3, and higher IL-6, IL-1\u03b2, and IL-17 levels. Serum SIRT3 was inversely correlated with IL-1\u03b2 and IL-17. ROC analysis suggested SIRT3 as a potential predictive biomarker for POD. Logistic regression identified low SIRT3, low albumin, and elevated IL-1\u03b2 and IL-17 as risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2025-1359_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum SIRT3 is significantly reduced in elderly POD patients and may serve as a predictive biomarker and potential therapeutic target for\u00a0POD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2025-1359","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:59:49Z","timestamp":1783443589000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum levels of SIRT3 in elderly patients undergoing general anesthesia and its relationship with postoperative delirium"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1073-5983","authenticated-orcid":false,"given":"Linfeng","family":"Li","sequence":"first","affiliation":[{"name":"Anesthesiology and Operating Room Center , The Third People\u2019s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University , Chengdu , Sichuan , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anesthesiology and Operating Room Center , The Third People\u2019s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University , Chengdu , Sichuan , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2850-8773","authenticated-orcid":false,"given":"Rong","family":"Qian","sequence":"additional","affiliation":[{"name":"Anesthesiology and Operating Room Center , The Third People\u2019s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University , Chengdu , Sichuan , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuiJuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Anesthesiology and Operating Room Center , The Third People\u2019s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University , Chengdu , Sichuan , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anesthesiology and Operating Room Center , The Third People\u2019s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University , Chengdu , Sichuan , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tang","sequence":"additional","affiliation":[{"name":"Anesthesiology and Operating Room Center , The Third People\u2019s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University , Chengdu , Sichuan , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5798-453X","authenticated-orcid":false,"given":"Min","family":"Liao","sequence":"additional","affiliation":[{"name":"Anesthesiology and Operating Room Center , The Third People\u2019s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University , Chengdu , Sichuan , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"2026070716583175293_j_med-2025-1359_ref_001","doi-asserted-by":"crossref","unstructured":"Jin, Z, Hu, J, Ma, D. Postoperative delirium: perioperative assessment, risk reduction, and management. Br J Anaesth 2020;125:492\u2013504. https:\/\/doi.org\/10.1016\/j.bja.2020.06.063.","DOI":"10.1016\/j.bja.2020.06.063"},{"key":"2026070716583175293_j_med-2025-1359_ref_002","doi-asserted-by":"crossref","unstructured":"Oh, S-T, Park, JY. Postoperative delirium. 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