{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T16:59:34Z","timestamp":1772297974210,"version":"3.50.1"},"reference-count":6,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1376_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Congenital acute megakaryoblastic leukemia (AMKL) is an extremely rare and aggressive malignancy with poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1376_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      We report a female neonate with Down syndrome (DS) who presented with respiratory distress and hepatomegaly at birth. Laboratory evaluation revealed hyperleukocytosis (253.45\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L) and bone marrow studies confirmed AMKL with trisomy 21. Remarkably, spontaneous hematologic remission occurred within 2\u00a0months without chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1376_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights the unique clinical course of DS-associated AMKL and underscores the potential for spontaneous regression in congenital leukemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2025-1367","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T16:07:38Z","timestamp":1772294858000},"source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous remission of congenital acute megakaryoblastic leukemia in a neonate with down syndrome"],"prefix":"10.1515","volume":"21","author":[{"given":"Wei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatric , The People\u2019s Hospital of Bozhou , Bozhou , China"},{"name":"Department of General Pediatric , Bozhou Children\u2019s Hospital , Bozhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumin","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Pediatric , The People\u2019s Hospital of Bozhou , Bozhou , China"},{"name":"Department of General Pediatric , Bozhou Children\u2019s Hospital , Bozhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-7108","authenticated-orcid":false,"given":"Sheng","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pediatric , The People\u2019s Hospital of Bozhou , Bozhou , China"},{"name":"Department of General Pediatric , Bozhou Children\u2019s Hospital , Bozhou , China"},{"name":"Department of Nephrology, Rheumatology and Immunology , Shanghai Children\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"2026022816073463915_j_med-2025-1367_ref_001","doi-asserted-by":"crossref","unstructured":"Green, K, Tandon, S, Ahmed, M, Toscano, W, O\u2019Connor, D, Ancliff, P, et al.. Congenital acute myeloid leukemia: challenges and lessons. A 15-year experience from the UK. Leuk Lymphoma 2021;62:688\u201395. https:\/\/doi.org\/10.1080\/10428194.2020.1845335.","DOI":"10.1080\/10428194.2020.1845335"},{"key":"2026022816073463915_j_med-2025-1367_ref_002","doi-asserted-by":"crossref","unstructured":"Tsujimoto, H, Kounami, S, Mitani, Y, Watanabe, T, Takifuji, K. Neonatal acute megakaryoblastic leukemia presenting with leukemia cutis and multiple intracranial lesions successfully treated with unrelated cord blood transplantation. Case Rep Hematol 2015;2015:610581\u20134. https:\/\/doi.org\/10.1155\/2015\/610581.","DOI":"10.1155\/2015\/610581"},{"key":"2026022816073463915_j_med-2025-1367_ref_003","doi-asserted-by":"crossref","unstructured":"Wu, K, Liu, H, Hu, W, Liu, Y, Wu, W, Cui, B, et al.. Clinically associated genomic landscape of pediatric non-down syndrome acute megakaryoblastic leukemia in Chinese patients. Leukemia 2025;39:2533\u20137. https:\/\/doi.org\/10.1038\/s41375-025-02741-0.","DOI":"10.1038\/s41375-025-02741-0"},{"key":"2026022816073463915_j_med-2025-1367_ref_004","doi-asserted-by":"crossref","unstructured":"Hasle, H, Kline, RM, Kjeldsen, E, Nik-Abdul-Rashid, NF, Bhojwani, D, Verboon, JM, et al.. Germline GATA1s-generating mutations predispose to leukemia with acquired trisomy 21 and down syndrome-like phenotype. Blood 2022;139:3159\u201365. https:\/\/doi.org\/10.1182\/blood.2021011463.","DOI":"10.1182\/blood.2021011463"},{"key":"2026022816073463915_j_med-2025-1367_ref_005","doi-asserted-by":"crossref","unstructured":"Guo, SB, Meng, Y, Lin, L, Zhou, ZZ, Li, HL, Tian, XP, et al.. Artificial intelligence alphafold model for molecular biology and drug discovery: a machine-learning-driven informatics investigation. 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