{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T21:11:07Z","timestamp":1778361067374,"version":"3.51.4"},"reference-count":139,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    has an extensive history in traditional folk medicine. There is a robust scientific literature on\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    extracts and several prominent chemical constituents, covering chemical characterization, biological\/chemoprotective effects, and mechanisms. This paper provides the first integrative assessment of\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    -induced hormetic dose responses.\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    extract-induced hormetic responses acted as an immunostimulant in multiple fish species, enhancing development\/growth and reducing adverse effects from environmental stressors.\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    extract-induced hormetic effects are prominent in dermatological studies, improving keratinocyte- and fibroblast-related wound-healing processes.\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    extracts induced hormetic-based neuroprotective endpoints for epileptic seizures, pain, in Alzheimer\u2019s disease models, and for lifespan. This analysis includes the hormetic effects of specific chemical constituents of\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    extracts (acemannan\/aloin) on stem cells, cardiomyocytes, bone cells, and other cell types, and their mechanisms. These findings show that a complex range of\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    extract mixtures\/specific constituents induce hormetic dose responses. These findings also indicate that hormetic dose responses play a prominent role in mediating many biomedical and chemopreventive effects of\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    extracts and their major chemical constituents. Recognition of these findings should assist in creating optimized hormetic-based study designs and improving biologically\/mechanistically based interpretations of their dose-response findings with their clinical implications.\n                  <\/jats:p>","DOI":"10.1515\/med-2026-1392","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T20:52:47Z","timestamp":1778359967000},"source":"Crossref","is-referenced-by-count":0,"title":["Hormesis: induction by\n                    <i>Aloe vera<\/i>\n                    extracts and individual constituents"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-412X","authenticated-orcid":false,"given":"Edward J.","family":"Calabrese","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, Morrill I-N344 , School of Public Health and Health Sciences, University of Massachusetts , Amherst , MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Pressman","sequence":"additional","affiliation":[{"name":"University of Maine , Orono , ME , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Wallace","family":"Hayes","sequence":"additional","affiliation":[{"name":"Center for Environmental Occupational Risk Analysis and Management , College of Public Health, University of South Florida , Tampa , FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0058-4857","authenticated-orcid":false,"given":"Evgenios","family":"Agathokleous","sequence":"additional","affiliation":[{"name":"School of Ecology and Applied Meteorology, Nanjing University of Information Science & Technology , Nanjing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-7323","authenticated-orcid":false,"given":"Gaurav","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Sri Guru Ram Das (SGRD), University of Health Sciences , Amritsar , India"},{"name":"Independent Consultant , Hartford , CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0538-5440","authenticated-orcid":false,"given":"Rachna","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Saint Francis Hospital and Medical Center , Hartford , CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-985X","authenticated-orcid":false,"given":"Vittorio","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences , School of Medicine University of Catania , Catania , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"2026050920524065853_j_med-2026-1392_ref_001","doi-asserted-by":"crossref","unstructured":"Calabrese, EJ, Tsatsakis, A, Agathokleous, E, Giordano, J, Calabrese, V. 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