{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:38:12Z","timestamp":1773380292544,"version":"3.50.1"},"reference-count":53,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Tbilisi State Medical University \u2013 Program for Encouraging Young Doctoral Students"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1403_abs_002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the preventive and corrective effects of vitamin D on antioxidant defense and blood rheology in rats with streptozotocin (STZ)-induced diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1403_abs_003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty male rats (10\u00a0weeks old, \u223c200\u202fg) were randomly assigned to four groups: Group I\u00a0\u2013\u00a0Intact controls; Group II\u00a0\u2013\u00a0Diabetic rats (STZ only); Group III\u00a0\u2013\u00a0Preventive (vitamin D for 14\u00a0days before STZ and continued throughout the experiment); Group IV\u00a0\u2013\u00a0Therapeutic (vitamin D from day 3 post-STZ). DM was induced with streptozotocin (30\u202fmg\/kg), and vitamin D was administered orally at 300 IU\/day, according to a previous dose-control experiment. Data from the 21st experimental day were evaluated. Blood samples collected at this point were used to determine catalase (CAT),\u00a0superoxide dismutase (SOD), and blood rheological parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1403_abs_004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Vitamin D supplementation enhanced antioxidant-related parameters and improved blood rheological indices, particularly when administered therapeutically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1403_abs_005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vitamin D shows therapeutic potential in attenuating oxidative imbalance and improving blood rheology in streptozotocin-induced diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2026-1403","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:44:51Z","timestamp":1773351891000},"source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of vitamin D in improving antioxidant defense and blood rheology in a rat model of experimental diabetes mellitus"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1973-3580","authenticated-orcid":false,"given":"Nino","family":"Sakhanberidze","sequence":"first","affiliation":[{"name":"Department of Pathophysiology and Endocrinology , Tbilisi State Medical University , Tbilisi , Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1897-0361","authenticated-orcid":false,"given":"Manana","family":"Namoradze","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology , Tbilisi State Medical University , Tbilisi , Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7826-3954","authenticated-orcid":false,"given":"Nino","family":"Charkviani","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Tbilisi State Medical University , Tbilisi , Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-0872","authenticated-orcid":false,"given":"Maia","family":"Mantskava","sequence":"additional","affiliation":[{"name":"Department of Physics, Biophysics, Biomechanics and Informational Technologies , Tbilisi State Medical University , Tbilisi , Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3065-1405","authenticated-orcid":false,"given":"Nana","family":"Momtselidze","sequence":"additional","affiliation":[{"name":"Department of Rheological and Diagnostic-Analytical Services , Ivane Beritashvili Experimental Center of Biomedicine , Tbilisi , Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4220-4181","authenticated-orcid":false,"given":"Davit","family":"Delibashvili","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology , Tbilisi State Medical University , Tbilisi , Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8057-2204","authenticated-orcid":false,"given":"Natia","family":"Gamkrelidze","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology , Tbilisi State Medical University , Tbilisi , Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"2026031221444622760_j_med-2026-1403_ref_001","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee. 2. 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