{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:50:23Z","timestamp":1782391823000,"version":"3.54.5"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1406_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the neuroprotective effects of adalimumab against cisplatin-induced cognitive impairment (CICI) and to evaluate its potential to ameliorate anxiety- and depression-like behaviors as well as learning and memory deficits through modulation of Tumor necrosis factor-\u03b1 (TNF-\u03b1)\u2013mediated neuroinflammation, cholinergic homeostasis, and apoptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1406_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult male Wistar rats were divided into four groups (n=6\/group): Control, Cisplatin (2\u202fmg\/kg\/day, i.p., 10 days), ADA (10\u202fmg\/kg, i.p., three doses), and Cisplatin + ADA. Anxiety-, depression-like behaviors and memory performance were assessed using the open field test, elevated plus maze, forced swim test, and novel object recognition test. Serum and hippocampal TNF-\u03b1, nitric oxide (NO), acetylcholinesterase (AChE), acetylcholine (ACh), and p53 levels were measured by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1406_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cisplatin induced anxiety- and depression-like behaviors and impaired recognition memory without affecting locomotor activity. These behavioral alterations were accompanied by increased TNF-\u03b1, NO, AChE, and p53 levels in the hippocampus. ADA treatment significantly reversed behavioral deficits and normalized inflammatory, cholinergic, and stress-related markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1406_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adalimumab attenuates cisplatin-induced cognitive and mood disturbances, likely through modulation of TNF-\u03b1\u2013mediated neuroinflammation, cholinergic imbalance, and stress-related signaling pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2026-1406","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:56:19Z","timestamp":1782388579000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of adalimumab on anxiety-depression-like behaviors and learning in rats receiving cisplatin"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-2767","authenticated-orcid":false,"given":"Durmu\u015f Ali","family":"Aslanlar","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine , Necmettin Erbakan University , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-2623","authenticated-orcid":false,"given":"Mehmet","family":"\u00d6z","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine , Aksaray University , Aksaray , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4107-5389","authenticated-orcid":false,"given":"F. H\u00fcmeyra","family":"Yerlikaya Aydemir","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine , Selcuk University , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2301-7887","authenticated-orcid":false,"given":"K.Esra","family":"Nurullahoglu Atalik","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine , Necmettin Erbakan University , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"2026062511561255164_j_med-2026-1406_ref_001","doi-asserted-by":"crossref","unstructured":"Fleming, B, Edison, P, Kenny, L. Cognitive impairment after cancer treatment: mechanisms, clinical characterization, and management. 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