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In light of this, the present study aims to address the following questions: Through which specific molecular pathways and mechanisms does curcumin regulate platelets and their derived factors, thereby exerting therapeutic effects on diseases in different systems? Additionally, this research seeks to provide a theoretical foundation for further exploration of novel therapeutic directions for curcumin in disease treatment.<\/jats:p>","DOI":"10.1515\/med-2026-1430","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:11:29Z","timestamp":1777497089000},"source":"Crossref","is-referenced-by-count":0,"title":["Platelets and platelet-derived factors in curcumin treatment: a narrative review of mechanisms and translational potential"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9082-4603","authenticated-orcid":false,"given":"Dandan","family":"Li","sequence":"first","affiliation":[{"name":"The Second Hospital of Lanzhou University , Lanzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-569X","authenticated-orcid":false,"given":"Yuxin","family":"Huo","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Central South University , Changsha , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9855-1655","authenticated-orcid":false,"given":"Mutalifu","family":"Xiaheidan","sequence":"additional","affiliation":[{"name":"The Second Clinical College of Lanzhou University , Lanzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8216-7335","authenticated-orcid":false,"given":"Xiaotong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Biosafety, Lanzhou University , Lanzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1732-8662","authenticated-orcid":false,"given":"Difeng","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , Lanzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2410-6975","authenticated-orcid":false,"given":"Zihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion , the Second Hospital of Lanzhou University , Lanzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"2026042921103419939_j_med-2026-1430_ref_001","doi-asserted-by":"crossref","unstructured":"Hussain, Y, Abdullah, KF, Alsharif, KF, Alzahrani, KJ, Saso, L, Khan, H. 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