{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:06:47Z","timestamp":1779210407032,"version":"3.51.4"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1435_abs_002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to compare serum neopterin and other inflammatory marker levels between patients with rosacea and healthy controls and to investigate the potential role of neopterin in disease diagnosis and severity assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1435_abs_003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty drug-naive patients clinically diagnosed with papulopustular rosacea and forty healthy controls were included. The serum levels of neopterin and other inflammatory markers were measured. The Investigator\u2019s Global Assessment (IGA) score was used to assess the patient\u2019s disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1435_abs_004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum neopterin, TNF-\u03b1, IFN-\u03b3, and CRP levels were significantly higher in patients with papulopustular rosacea than in controls. A positive correlation was found between neopterin, TNF-\u03b1, IFN-\u03b3, and IGA scores (r=0.498, 0.523, and 0.432, respectively). ROC curve analysis demonstrated good diagnostic performance for IFN-\u03b3 (AUC=0.821), TNF-\u03b1 (AUC=0.780), and neopterin (AUC=0.747).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1435_abs_005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>New biochemical markers are needed to assess rosacea severity. Neopterin may be a potential biomarker for rosacea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2026-1435","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:21:37Z","timestamp":1779207697000},"source":"Crossref","is-referenced-by-count":0,"title":["Could high serum neopterin levels serve as a biomarker for patients diagnosed with rosacea, specifically the papulopustular rosacea subtype?"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7940-4590","authenticated-orcid":false,"given":"K\u00fcbranur","family":"\u00dcnal","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry , Faculty of Medicine , Gazi University , Ankara , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9407-5289","authenticated-orcid":false,"given":"Mehmet Alp","family":"Sert","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry , Kutahya City Hospital , K\u00fctahya , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-3486","authenticated-orcid":false,"given":"Name","family":"Cem\u015fito\u011flu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology , Acibadem Fulya Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011fr\u0131 Emin","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Epidemiology Program, Institute of Health Sciences, Istanbul Medipol University , \u0130stanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-1883","authenticated-orcid":false,"given":"Mehmet Emre","family":"Erol","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Institute of Health Sciences, Gazi University , Ankara , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilsel","family":"\u0130lter","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology , Faculty of Medicine , Gazi University , Ankara , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"2026051916213347379_j_med-2026-1435_ref_001","doi-asserted-by":"crossref","unstructured":"Sharma, A, Kroumpouzos, G, Kassir, M, Galadari, H, Goren, A, Grabbe, S, et al.. Rosacea management: a comprehensive review. J\u00a0Cosmet Dermatol 2022;21:1895\u2013904. https:\/\/doi.org\/10.1111\/jocd.14816.","DOI":"10.1111\/jocd.14816"},{"key":"2026051916213347379_j_med-2026-1435_ref_002","unstructured":"Farshchian, M, Daveluy, S. Rosacea. editor. StatPearls. ed. Treasure Island(FL): Statpearls Publishing Copyright \u00a9 2025, StatPearls Publishing LLC.; 2025."},{"key":"2026051916213347379_j_med-2026-1435_ref_003","doi-asserted-by":"crossref","unstructured":"van Zuuren, EJ, Arents, BWM, van der Linden, MMD, Vermeulen, S, Fedorowicz, Z, Tan, J. Rosacea: new concepts in classification and treatment. Am J Clin Dermatol 2021;22:457\u201365. https:\/\/doi.org\/10.1007\/s40257-021-00595-7.","DOI":"10.1007\/s40257-021-00595-7"},{"key":"2026051916213347379_j_med-2026-1435_ref_004","doi-asserted-by":"crossref","unstructured":"Engin, B, Oba, M\u00c7, Kutlubay, Z, Serdaro\u011flu, S, T\u00fcz\u00fcn, Y. Acne Rosacea. editor. Acne and Acneiform Eruptions. ed. 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