{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:45:31Z","timestamp":1785750331359,"version":"3.56.0"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1444_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study analyzes clinical features and placental pathology of pregnant women infected with SARS-CoV-2 Omicron variants and conducts a two-year follow-up to assess childbirth risks and newborn health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1444_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of 46\u00a0Omicron-infected pregnant women (Omicron group) and 96 uninfected pregnant women (Control group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1444_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Omicron group exhibited higher risk of fetal distress rate, lower leukocyte and lymphocyte counts, and higher C-reactive protein levels compared to the control group. Most infected women (93.48\u202f%) were symptomatic, with fever being the most common symptom. Histologically, acute maternal and fetal inflammatory response were observed in 28.26 and 8.70\u202f% of the Omicron group, but no significant difference from the control group. Maternal vascular malperfusion (50.00\u202f%) and fetal vascular malperfusion (4.34\u202f%) were present in the Omicron group at rates comparable to the controls. Among the 39.13\u202f% of newborns tested for SARS-CoV-2 within three days of birth, 33.33\u202f% tseted positive. Of these positive neonates, 83.33\u202f% were symptomatic, universally presenting with fever, and one developed pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1444_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Placental pathological findings were non-specific to the Omicron variant. Notably, the two-year follow-up indicated that neither the Omicron-infected mothers nor their newborns experienced long-term adverse health outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2026-1444","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:58:31Z","timestamp":1785747511000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of SARS-CoV-2 Omicron infection on late pregnancy: an analysis of clinical characteristics, pathology of placenta and outcomes in a case-control study"],"prefix":"10.1515","volume":"21","author":[{"given":"Heping","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology , Anhui Women and Children\u2019s Medical Center, Hefei Maternity and Child Health Hospital, Anhui Medical University , Hefei , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-3243","authenticated-orcid":false,"given":"Hongliang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology , Anhui Women and Children\u2019s Medical Center, Hefei Maternity and Child Health Hospital, Anhui Medical University , Hefei , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-947X","authenticated-orcid":false,"given":"Shuguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Anhui Maternity and Child Health Hospital , Hefei , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3612-0593","authenticated-orcid":false,"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology , Anhui Women and Children\u2019s Medical Center, Hefei Maternity and Child Health Hospital, Anhui Medical University , Hefei , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5459-1984","authenticated-orcid":false,"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology , Anhui Women and Children\u2019s Medical Center, Hefei Maternity and Child Health Hospital, Anhui Medical University , Hefei , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9861-2057","authenticated-orcid":false,"given":"Caixia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology , Anhui Women and Children\u2019s Medical Center, Hefei Maternity and Child Health Hospital, Anhui Medical University , Hefei , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9780-0169","authenticated-orcid":false,"given":"Man","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology , Anhui Women and Children\u2019s Medical Center, Hefei Maternity and Child Health Hospital, Anhui Medical University , Hefei , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4065-2910","authenticated-orcid":false,"given":"Weiqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology , Anhui Women and Children\u2019s Medical Center, Hefei Maternity and Child Health Hospital, Anhui Medical University , Hefei , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2026080308582984369_j_med-2026-1444_ref_001","unstructured":"Organization, WH. 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Ital J Pediatr 2020;46:56. https:\/\/doi.org\/10.1186\/s13052-020-0820-x.","DOI":"10.1186\/s13052-020-0820-x"},{"key":"2026080308582984369_j_med-2026-1444_ref_020","doi-asserted-by":"crossref","unstructured":"Zhu, H, Wang, L, Fang, C, Peng, S, Zhang, L, Chang, G, et al.. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr 2020;9:51\u201360. https:\/\/doi.org\/10.21037\/tp.2020.02.06.","DOI":"10.21037\/tp.2020.02.06"},{"key":"2026080308582984369_j_med-2026-1444_ref_021","doi-asserted-by":"crossref","unstructured":"Roland, MCP, Friis, CM, Voldner, N, Godang, K, Bollerslev, J, Haugen, G, et al.. Fetal growth versus birthweight: the role of placenta versus other determinants. PLoS One 2012;7:e39324. Harvey N. https:\/\/doi.org\/10.1371\/journal.pone.0039324.","DOI":"10.1371\/journal.pone.0039324"},{"key":"2026080308582984369_j_med-2026-1444_ref_022","doi-asserted-by":"crossref","unstructured":"Walker, K, O\u2019Donoghue, K, Grace, N, Dorling, J, Comeau, J, Li, W, et al.. Maternal transmission of SARS-CoV-2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG Int J Obstet Gynaecol 2020;127:1324\u201336. https:\/\/doi.org\/10.1111\/1471-0528.16362.","DOI":"10.1111\/1471-0528.16362"},{"key":"2026080308582984369_j_med-2026-1444_ref_023","doi-asserted-by":"crossref","unstructured":"Patil, UP, Maru, S, Krishnan, P, Carroll-Bennett, R, Sanchez, J, Noble, L, et al.. Newborns of COVID-19 mothers: short-term outcomes of colocating and breastfeeding from the pandemic\u2019s epicenter. 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